Kinase-Ligand Interaction Fingerprints and Structures database (KLIFS), developed at the Division of Medicinal Chemistry - VU University Amsterdam, is a database that revolves around the protein structure of catalytic kinase domains and the way kinase inhibitors can interact with them. Based on the underlying systematic and consistent protocol all (currently human and mouse) kinase structures and the binding mode of kinase ligands can be directly compared to each other. Moreover, because of the classification of an all-encompassing binding site of 85 residues it is possible to compare the interaction patterns of kinase-inhibitors to each other to, for example, identify crucial interactions determining kinase-inhibitor selectivity.

Follow the tutorial, read our Nucleic Acids Research publication and ACS Journal of Medicinal Chemistry publication, or see the frequently asked questions (FAQ) for more information about the possibilities of KLIFS.

Animation of the stuctural kinome coverage through time here.

News:
08-Feb-2017

Publication and release 3D-e-Chem-VM


16-Nov-2016

Release version 2.2 - the Virtual Reality release


News archive

Read more

Contents:
Species: 2
Groups: 8
Families: 89
Kinases: 258
PDB entries: 3513
Monomers: 7299
Unique ligands: 2216

Latest additions:
PDBKinaseFamilyGroupLigand
NTRK1TrkTK1-[(3S,4R)-4-[3,4-bis(fluoranyl)phenyl]-1-(2-methoxyethyl)pyrrolidin-3-yl]-3-(5-ethoxy-4-methyl-2-phenyl-pyrazol-3-yl)urea
MERTKAxlTK(7S)-7-amino-N-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide
PLK1PLKOther4-{[(6R)-7-cyano-5-cyclopentyl-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
PLK1PLKOther4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
JAK3JakATK1-{(3R)-3-[(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}propan-1-one
JAK3JakATK1-[(3aR,7aR)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)octahydro-6H-pyrrolo[2,3-c]pyridin-6-yl]propan-1-one
JAK3JakATKN-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]propanamide
FGFR2FGFRTKPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
FGFR2FGFRTKPHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
FGFR2FGFRTKPHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
FGFR2FGFRTKPHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
FGFR2FGFRTK-
Mapk14MAPKCMGC-
FGFR1FGFRTK2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carboxamide
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