Kinase-Ligand Interaction Fingerprints and Structures database (KLIFS), developed at the Division of Medicinal Chemistry - VU University Amsterdam, is a database that revolves around the protein structure of catalytic kinase domains and the way kinase inhibitors can interact with them. Based on the underlying systematic and consistent protocol all (currently human and mouse) kinase structures and the binding mode of kinase ligands can be directly compared to each other. Moreover, because of the classification of an all-encompassing binding site of 85 residues it is possible to compare the interaction patterns of kinase-inhibitors to each other to, for example, identify crucial interactions determining kinase-inhibitor selectivity.

Follow the tutorial, read our Nucleic Acids Research publication and ACS Journal of Medicinal Chemistry publication, or see the frequently asked questions (FAQ) for more information about the possibilities of KLIFS.

Animation of the stuctural kinome coverage through time here.

News:
08-Feb-2017

Publication and release 3D-e-Chem-VM


16-Nov-2016

Release version 2.2 - the Virtual Reality release


News archive

Read more

Contents:
Species: 2
Groups: 8
Families: 89
Kinases: 258
PDB entries: 3573
Monomers: 7477
Unique ligands: 2267

Latest additions:
PDBKinaseFamilyGroupLigand
CSNK2A1CK2CMGC(3-chloranyl-4-phenyl-phenyl)methyl-propyl-azanium
CSNK2A1CK2CMGC-
CSNK2A1CK2CMGC~{N}'-[(3-chloranyl-4-phenyl-phenyl)methyl]butane-1,4-diamine
CSNK2A1CK2CMGC-
CSNK2A1CK2CMGC~{N}-[3-[(3-chloranyl-4-phenyl-phenyl)methylamino]propyl]methanesulfonamide
CSNK2A1CK2CMGC-
CSNK2A1CK2CMGC3-[3-[(3-chloranyl-4-phenyl-phenyl)methylamino]propylamino]-3-oxidanylidene-propanoic acid
CSNK2A1CK2CMGC-
CSNK2A1CK2CMGC3-[(3-chloranyl-4-phenyl-phenyl)methylamino]propanamide
CSNK2A1CK2CMGC-
CSNK2A1CK2CMGC3-[[3-[3-[(3-chloranyl-4-phenyl-phenyl)methylamino]propylamino]-3-oxidanylidene-propanoyl]amino]benzoic acid
CSNK2A1CK2CMGC-
CSNK2A1CK2CMGCADENOSINE-5'-DIPHOSPHATE
CSNK2A1CK2CMGC2-(3-methoxy-4-oxidanyl-phenyl)ethanoic acid
CSNK2A1CK2CMGC4-HYDROXYBENZAMIDE
CSNK2A1CK2CMGC4'-HYDROXYCINNAMIC ACID
CSNK2A1CK2CMGC5-bromopyridine-2,3-diamine
CSNK2A1CK2CMGC-
CSNK2A1CK2CMGCADENOSINE-5'-DIPHOSPHATE
CSNK2A1CK2CMGCADENOSINE-5'-DIPHOSPHATE
CSNK2A1CK2CMGC-
SRPK2SRPKCMGC5-methyl-~{N}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide
LIMK1LISKTKL(2~{R})-2-azanyl-2-cyclohexyl-~{N}-[2-(1-methylpyrazol-4-yl)-9-oxidanylidene-3,10,11-triazatricyclo[6.4.1.0^{4,13}]trideca-1,4,6,8(13),11-pentaen-6-yl]ethanamide
LIMK2LISKTKL4-[(3-chlorophenyl)sulfamoyl]-~{N}-(phenylmethyl)-~{N}-propyl-benzamide
BTKTecTKN-{3-[6-({4-[(2R)-1,4-dimethyl-3-oxopiperazin-2-yl]phenyl}amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl]-2-methylphenyl}-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide
BTKTecTK6-cyclopropyl-8-fluoranyl-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]-6-oxidanylidene-pyridin-3-yl]phenyl]isoquinolin-1-one
BTKTecTK6-~{tert}-butyl-8-fluoranyl-2-[3-(hydroxymethyl)-4-[1-methyl-5-[[5-(1-methylpiperidin-4-yl)pyridin-2-yl]amino]-6-oxidanylidene-pyridazin-3-yl]pyridin-2-yl]phthalazin-1-one
BTKTecTK1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one
BTKTecTK1-[(3~{R})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one
BTKTecTK4-[4-[[5-fluoranyl-4-[[3-(propanoylamino)phenyl]amino]pyrimidin-2-yl]amino]phenoxy]-~{N}-methyl-pyridine-2-carboxamide
BTKTecTK~{N}-[3-[[5-fluoranyl-2-[[4-(2-methoxyethoxy)phenyl]amino]pyrimidin-4-yl]amino]phenyl]propanamide
BTKTecTK6-azanyl-9-[(3~{R})-1-[(~{E})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one
IRAK4IRAKTKL2-[(propan-2-yl)oxy]benzamide
IRAK4IRAKTKL5-(4-cyanophenyl)-3-[(propan-2-yl)oxy]naphthalene-2-carboxamide
IRAK4IRAKTKL4-{[(3R)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide
IRAK4IRAKTKL1-{[(2S)-5-oxopyrrolidin-2-yl]methoxy}-7-[(propan-2-yl)oxy]isoquinoline-6-carboxamide
IRAK4IRAKTKL1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide
FGFR1FGFRTKN-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-5-(4-ethylpiperazin-1-yl)phenyl}propanamide
CAMKK2CAMKKOther4-({5-[(3-hydroxy-4-methylphenyl)amino]-4-oxo-4H-1,2,6-thiadiazin-3-yl}amino)benzamide
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