6GTT - chain A (model A) | Serine/threonine kinase 10
Structure information
PDB: | 6GTT |
PubMed: | - |
Release date: | 2018-06-27 |
Resolution: | 2.25 Å |
Kinase: | STK10 (LOK) |
Family: | STE20 |
Group: | STE |
Species: | HUMAN |
Quality Score: | 8.5 |
Missing Residues: | 2 |
Missing Atoms: | 7 |
DFG conformation: | out |
αC-helix conformation: | in |
Salt bridge KIII.17 and EαC.24: | Yes (2.9Å) |
ASP rotation (xDFG.81) : | 200° |
PHE rotation (xDFG.82) : | 192° |
Activation loop position: | 1.7Å |
αC-helix position: | 19.1Å |
G-rich loop angle: | 54° |
G-rich loop distance: | 17.2Å |
G-rich loop rotation: | 39.3° |
Other models from this PDB:
2D & 3D views
Binding pocket waters
No waters were found in the defined clusters
Binding pocket sequence
Uniprot | GELGDGAFGKVYKAAAKVIDYIVEIEILATCDPYIVKLLGAWIMIEFCPGGAVDAIMLEFLHSKRIIHRDLKAGNVLMLADFGVS |
Structure: | GELGDGAFGKVYKAAAKVIDYIVEIEILATCDPYIVKLLGAWIMIEFCPGGAVDAIMLEFLHSKRIIHRDLKAGNVLMLADFG__ |
Modified residues
No modified residues identified.
Orthosteric ligand
Ligand HET-code: B96
Ligand Name: 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA
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- LABELS
- KLIFS residue #
- Amino Acid
- None
- COLORS
- Interaction types
- KLIFS (all res.)
- KLIFS (interacting res.)
- None
- OTHER
- Show/hide non-interacting res.
- En/disable resizing interacting res.
This ligand targets the following (sub)pockets:
Main pockets | |
---|---|
Front | |
Gate | |
Back |
Subpockets | |
---|---|
FP-I | |
FP-II | |
BP-I-A | |
BP-I-B | |
BP-II-in | |
BP-II-A-in | |
BP-II-B-in | |
BP-II-out | |
BP-II-B | |
BP-III | |
BP-IV | |
BP-V |
Kinase-ligand interactions
■ Hydrophobic ♦ Aromatic face-to-face ♦ Aromatic face-to-edge ▲ H-bond donor ▲ H-bond acceptor ● Ionic positive ● Ionic negative
I | g.l | II | III | αC | |||||||||||||||
1 G 40 | 2 E 41 | 3 L 42 | 4 G 43 | 5 D 44 | 6 G 45 | 7 A 46 | 8 F 47 | 9 G 48 | 10 K 49 | 11 V 50 | 12 Y 51 | 13 K 52 | 14 A 62 | 15 A 63 | 16 A 64 | 17 K 65 | 18 V 66 | 19 I 67 | 20 D 77 |
■ | ■ | ■ | ■ | ■ | |||||||||||||||
αC | b.l | IV | |||||||||||||||||
21 Y 78 | 22 I 79 | 23 V 80 | 24 E 81 | 25 I 82 | 26 E 83 | 27 I 84 | 28 L 85 | 29 A 86 | 30 T 87 | 31 C 88 | 32 D 89 | 33 P 91 | 34 Y 92 | 35 I 93 | 36 V 94 | 37 K 95 | 38 L 96 | 39 L 97 | 40 G 98 |
■▲ | ■ | ■ | ■ | ■ | ■ | ||||||||||||||
IV | V | GK | hinge | linker | αD | αE | |||||||||||||
41 A 99 | 42 W 107 | 43 I 108 | 44 M 109 | 45 I 110 | 46 E 111 | 47 F 112 | 48 C 113 | 49 P 114 | 50 G 115 | 51 G 116 | 52 A 117 | 53 V 118 | 54 D 119 | 55 A 120 | 56 I 121 | 57 M 122 | 58 L 123 | 59 E 124 | 60 F 147 |
■ | ■ | ■ | ■▲ | ||||||||||||||||
αE | VI | c.l | VII | VIII | x | ||||||||||||||
61 L 148 | 62 H 149 | 63 S 150 | 64 K 151 | 65 R 152 | 66 I 153 | 67 I 154 | 68 H 155 | 69 R 156 | 70 D 157 | 71 L 158 | 72 K 159 | 73 A 160 | 74 G 161 | 75 N 162 | 76 V 163 | 77 L 164 | 78 M 165 | 79 L 173 | 80 A 174 |
■ | ■ | ■ | ■ | ■ | |||||||||||||||
DFG | a.l | ||||||||||||||||||
81 D 175 | 82 F 176 | 83 G 177 | 84 _ _ | 85 _ _ | |||||||||||||||
■▲ | ■♦ |
Binding affinities
ChEMBL ID:CHEMBL103667Bioaffinities: 329 records for 92 kinase(s)
Species | Kinase (ChEMBL naming) | Median | Min | Max | Type | Records |
---|---|---|---|---|---|---|
Homo sapiens | Activin receptor type-1B | 4.4 | 4.4 | 4.4 | pIC50 | 1 |
Homo sapiens | Ankyrin repeat and protein kinase domain-containing protein 1 | 6 | 6 | 6 | pKd | 2 |
Homo sapiens | CaM kinase II beta | 4.4 | 4.4 | 4.4 | pIC50 | 1 |
Homo sapiens | Cell division cycle 2-like protein kinase 6 | 6.7 | 6.7 | 6.7 | pKd | 2 |
Homo sapiens | Cell division protein kinase 8 | 6.7 | 6.7 | 6.7 | pKd | 2 |
Homo sapiens | Cell division protein kinase 8 | 6.8 | 6.8 | 6.8 | pKi | 1 |
Homo sapiens | Citron Rho-interacting kinase | 5.7 | 5.7 | 5.7 | pKd | 2 |
Homo sapiens | c-Jun N-terminal kinase 1 | 5 | 5 | 5 | pKd | 1 |
Homo sapiens | c-Jun N-terminal kinase 2 | 7.6 | 6.8 | 8.2 | pIC50 | 7 |
Homo sapiens | c-Jun N-terminal kinase 2 | 8.1 | 8.1 | 8.3 | pKd | 4 |
Homo sapiens | c-Jun N-terminal kinase 2 | 8.2 | 8.2 | 8.2 | pKi | 1 |
Homo sapiens | c-Jun N-terminal kinase 3 | 5.9 | 5.9 | 5.9 | pIC50 | 2 |
Homo sapiens | c-Jun N-terminal kinase 3 | 7 | 7 | 7.2 | pKd | 4 |
Homo sapiens | c-Jun N-terminal kinase 3 | 7.4 | 7.4 | 7.4 | pKi | 1 |
Homo sapiens | Cyclin-dependent kinase 13 | 6 | 6 | 6 | pKd | 1 |
Homo sapiens | Cyclin-dependent kinase 5 | 5.7 | 5.7 | 6.4 | pKd | 3 |
Homo sapiens | Cyclin-dependent kinase 7 | 5.5 | 5.5 | 5.5 | pKd | 1 |
Homo sapiens | Discoidin domain-containing receptor 2 | 7.9 | 7.2 | 8 | pIC50 | 3 |
Homo sapiens | Discoidin domain-containing receptor 2 | 7.5 | 7.5 | 7.7 | pKd | 5 |
Homo sapiens | Dual specificity protein kinase TTK | 5.5 | 5.5 | 5.9 | pKd | 3 |
Homo sapiens | Ephrin type-A receptor 1 | 6.2 | 6.2 | 6.2 | pIC50 | 1 |
Homo sapiens | Ephrin type-A receptor 1 | 5 | 5 | 5 | pKd | 2 |
Homo sapiens | Ephrin type-A receptor 2 | 6.8 | 6.8 | 6.8 | pIC50 | 1 |
Homo sapiens | Ephrin type-A receptor 2 | 5.2 | 5.2 | 5.5 | pKd | 3 |
Homo sapiens | Ephrin type-A receptor 3 | 5.9 | 5.9 | 5.9 | pIC50 | 1 |
Homo sapiens | Ephrin type-A receptor 3 | 6.1 | 6.1 | 6.2 | pKd | 3 |
Homo sapiens | Ephrin type-A receptor 4 | 7.2 | 7.2 | 7.2 | pIC50 | 1 |
Homo sapiens | Ephrin type-A receptor 4 | 5.5 | 5.4 | 5.5 | pKd | 3 |
Homo sapiens | Ephrin type-A receptor 5 | 7.1 | 7.1 | 7.1 | pIC50 | 1 |
Homo sapiens | Ephrin type-A receptor 5 | 5.9 | 5.9 | 5.9 | pKd | 3 |
Homo sapiens | Ephrin type-A receptor 6 | 5.7 | 5.7 | 6.4 | pKd | 3 |
Homo sapiens | Ephrin type-A receptor 7 | 6.1 | 6.1 | 6.7 | pKd | 3 |
Homo sapiens | Ephrin type-A receptor 8 | 6.6 | 6.6 | 6.9 | pKd | 3 |
Homo sapiens | Ephrin type-B receptor 1 | 7 | 7 | 7 | pIC50 | 1 |
Homo sapiens | Ephrin type-B receptor 1 | 5.3 | 5.3 | 5.4 | pKd | 3 |
Homo sapiens | Ephrin type-B receptor 2 | 6.8 | 6.8 | 6.8 | pIC50 | 1 |
Homo sapiens | Ephrin type-B receptor 2 | 6.4 | 6.4 | 6.4 | pKd | 2 |
Homo sapiens | Ephrin type-B receptor 3 | 5 | 5 | 5 | pIC50 | 1 |
Homo sapiens | Ephrin type-B receptor 4 | 6.1 | 6.1 | 6.1 | pIC50 | 1 |
Homo sapiens | Epidermal growth factor receptor erbB1 | 5.4 | 5.4 | 5.4 | pIC50 | 1 |
Homo sapiens | Epidermal growth factor receptor erbB1 | 5.2 | 5 | 5.6 | pKd | 12 |
Homo sapiens | Epidermal growth factor receptor erbB1 | 6.7 | 6.7 | 6.7 | pKi | 1 |
Homo sapiens | Epithelial discoidin domain-containing receptor 1 | 8.7 | 8.7 | 8.7 | pKd | 3 |
Homo sapiens | Fibroblast growth factor receptor 1 | 4.8 | 4.8 | 4.8 | pIC50 | 1 |
Homo sapiens | Fibroblast growth factor receptor 1 | 5.4 | 5.4 | 5.4 | pKd | 2 |
Homo sapiens | Fibroblast growth factor receptor 2 | 4.6 | 4.6 | 4.6 | pIC50 | 1 |
Homo sapiens | Fibroblast growth factor receptor 4 | 5.2 | 5.2 | 5.2 | pIC50 | 1 |
Homo sapiens | Focal adhesion kinase 1 | 5.7 | 5.7 | 5.7 | pIC50 | 1 |
Homo sapiens | Focal adhesion kinase 1 | 5.2 | 5.2 | 5.2 | pKd | 2 |
Homo sapiens | Leukocyte tyrosine kinase receptor | 5.9 | 5.9 | 5.9 | pKd | 2 |
Homo sapiens | Macrophage colony stimulating factor receptor | 5.1 | 5.1 | 5.1 | pKd | 2 |
Homo sapiens | MAP kinase ERK2 | 5 | 5 | 5 | pIC50 | 1 |
Homo sapiens | MAP kinase-interacting serine/threonine-protein kinase MNK1 | 5.2 | 5.2 | 5.2 | pKd | 1 |
Homo sapiens | MAP kinase p38 alpha | 7.7 | 6.4 | 10 | pIC50 | 18 |
Homo sapiens | MAP kinase p38 alpha | 9.8 | 7.9 | 10.3 | pKd | 15 |
Homo sapiens | MAP kinase p38 alpha | 8.1 | 7.7 | 10 | pKi | 4 |
Mus musculus | MAP kinase p38 alpha | 10.3 | 10.3 | 10.3 | pKd | 1 |
Homo sapiens | MAP kinase p38 beta | 8.2 | 8.2 | 8.2 | pIC50 | 1 |
Homo sapiens | MAP kinase p38 beta | 6.7 | 5.8 | 8.1 | pKd | 3 |
Homo sapiens | MAP kinase p38 delta | 5.7 | 5.7 | 6.5 | pIC50 | 2 |
Homo sapiens | MAP kinase p38 delta | 7.1 | 7.1 | 7.1 | pKd | 1 |
Homo sapiens | MAP kinase p38 delta | 7.3 | 7.3 | 7.3 | pKi | 1 |
Homo sapiens | MAP kinase p38 gamma | 6.5 | 6.5 | 7.5 | pIC50 | 5 |
Homo sapiens | MAP kinase p38 gamma | 7.9 | 7.7 | 8.5 | pKd | 3 |
Homo sapiens | MAP kinase p38 gamma | 6.3 | 6.3 | 6.3 | pKi | 1 |
Homo sapiens | MAP kinase signal-integrating kinase 2 | 5.8 | 5.8 | 6 | pKd | 3 |
Homo sapiens | MAP/microtubule affinity-regulating kinase 2 | 4.4 | 4.4 | 4.4 | pIC50 | 1 |
Homo sapiens | Misshapen-like kinase 1 | 7.4 | 7.4 | 7.4 | pIC50 | 1 |
Homo sapiens | Misshapen-like kinase 1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase 15 | 5.5 | 5.5 | 5.5 | pKd | 2 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 7 | 6.8 | 6.8 | 6.8 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 4 | 7.1 | 7.1 | 7.1 | pKd | 2 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 4 | 6.8 | 6.8 | 6.8 | pKi | 1 |
Homo sapiens | Mixed lineage kinase 7 | 6.1 | 6.1 | 6.1 | pKd | 2 |
Homo sapiens | Muscle, skeletal receptor tyrosine protein kinase | 5.7 | 5.7 | 5.7 | pKd | 2 |
Homo sapiens | Nerve growth factor receptor Trk-A | 6.8 | 6.8 | 6.8 | pIC50 | 1 |
Homo sapiens | Nerve growth factor receptor Trk-A | 6 | 6 | 6.1 | pKd | 3 |
Homo sapiens | Neurotrophic tyrosine kinase receptor type 2 | 7.3 | 7.3 | 7.3 | pIC50 | 1 |
Homo sapiens | Neurotrophic tyrosine kinase receptor type 2 | 6.2 | 6.2 | 6.2 | pKd | 2 |
Homo sapiens | Neurotrophic tyrosine kinase receptor type 2 | 6.1 | 6.1 | 6.1 | pKi | 1 |
Homo sapiens | NT-3 growth factor receptor | 6.7 | 6.7 | 6.7 | pKd | 2 |
Homo sapiens | NT-3 growth factor receptor | 6.1 | 6.1 | 6.1 | pKi | 1 |
Homo sapiens | Platelet-derived growth factor receptor alpha | 5.9 | 5.9 | 5.9 | pKd | 2 |
Homo sapiens | Platelet-derived growth factor receptor beta | 5.2 | 5.2 | 5.2 | pIC50 | 1 |
Homo sapiens | Platelet-derived growth factor receptor beta | 6 | 6 | 6 | pKd | 3 |
Homo sapiens | Platelet-derived growth factor receptor beta | 5.9 | 5.9 | 5.9 | pKi | 1 |
Homo sapiens | Protein kinase C beta | 4.4 | 4.4 | 5.2 | pIC50 | 2 |
Homo sapiens | Protein kinase C delta | 5.7 | 5.7 | 5.7 | pIC50 | 1 |
Homo sapiens | Protein tyrosine kinase 2 beta | 4.9 | 4.9 | 6.4 | pIC50 | 2 |
Homo sapiens | Protein tyrosine kinase 2 beta | 6 | 6 | 6 | pKd | 2 |
Homo sapiens | Proto-oncogene tyrosine-protein kinase MER | 5.4 | 5.4 | 5.4 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase 10 | 7.9 | 7.9 | 8.2 | pKd | 3 |
Homo sapiens | Serine/threonine-protein kinase 2 | 6.8 | 6.8 | 7.1 | pKd | 3 |
Homo sapiens | Serine/threonine-protein kinase B-raf | 7.1 | 7.1 | 7.1 | pIC50 | 1 |
Homo sapiens | Serine/threonine-protein kinase B-raf | 5.6 | 5.6 | 5.6 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase Chk2 | 4.7 | 4.7 | 4.7 | pIC50 | 1 |
Homo sapiens | Serine/threonine-protein kinase D2 | 5.5 | 5.5 | 5.5 | pKi | 1 |
Homo sapiens | Serine/threonine-protein kinase MRCK-A | 5 | 5 | 5 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase MRCK beta | 6 | 6 | 6 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase MRCK gamma | 5.9 | 5.9 | 5.9 | pKd | 2 |
Homo sapiens | Serine/threonine protein kinase NLK | 6 | 6 | 6 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase RAF | 5.9 | 5.9 | 5.9 | pIC50 | 2 |
Homo sapiens | Serine/threonine-protein kinase RIPK2 | 5 | 5 | 5 | pIC50 | 1 |
Homo sapiens | Serine/threonine-protein kinase RIPK2 | 5.2 | 5.2 | 5.2 | pKd | 1 |
Homo sapiens | Stem cell growth factor receptor | 6.6 | 5.6 | 6.8 | pKd | 11 |
Homo sapiens | TRAF2- and NCK-interacting kinase | 6.9 | 6.9 | 8 | pKd | 4 |
Homo sapiens | Tyrosine-protein kinase ABL | 4.4 | 4.4 | 4.4 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase ABL | 5.6 | 5.1 | 7.4 | pKd | 18 |
Mus musculus | Tyrosine-protein kinase ABL | 4.8 | 4.8 | 4.8 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase ABL2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase BLK | 6.2 | 6.2 | 6.2 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase FER | 4.8 | 4.8 | 4.8 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase FGR | 5.1 | 5.1 | 5.1 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase FRK | 5.9 | 5.9 | 6.4 | pKd | 4 |
Homo sapiens | Tyrosine-protein kinase FYN | 4.6 | 4.6 | 4.6 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase HCK | 5.8 | 5.8 | 5.8 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase LCK | 4.5 | 4.5 | 5.7 | pIC50 | 2 |
Homo sapiens | Tyrosine-protein kinase LCK | 5.9 | 5.9 | 6 | pKd | 3 |
Homo sapiens | Tyrosine-protein kinase LCK | 5.7 | 5.7 | 5.7 | pKi | 1 |
Homo sapiens | Tyrosine-protein kinase Lyn | 6 | 6 | 6 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase Lyn | 5.6 | 5.6 | 5.6 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase Lyn | 6.2 | 6.2 | 6.2 | pKi | 1 |
Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 5.6 | 5.3 | 6.1 | pKd | 7 |
Homo sapiens | Tyrosine-protein kinase receptor RET | 7.5 | 7.5 | 7.5 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase receptor RET | 6.3 | 6.3 | 6.6 | pKd | 4 |
Homo sapiens | Tyrosine-protein kinase receptor Tie-1 | 8.1 | 8.1 | 8.1 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase receptor TYRO3 | 5.7 | 5.7 | 5.7 | pKi | 1 |
Homo sapiens | Tyrosine-protein kinase SRC | 4.5 | 4.5 | 4.5 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase TIE-2 | 7.6 | 7.6 | 7.6 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase TIE-2 | 7.7 | 7.7 | 8 | pKd | 3 |
Homo sapiens | Tyrosine-protein kinase YES | 5.1 | 5.1 | 5.1 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase YES | 5.3 | 5.3 | 5.3 | pKd | 2 |
Homo sapiens | Vascular endothelial growth factor receptor 1 | 6.6 | 6.6 | 6.6 | pIC50 | 1 |
Homo sapiens | Vascular endothelial growth factor receptor 1 | 6.4 | 6.4 | 6.4 | pKd | 2 |
Homo sapiens | Vascular endothelial growth factor receptor 1 | 5.6 | 5.6 | 5.6 | pKi | 1 |
Homo sapiens | Vascular endothelial growth factor receptor 2 | 6.5 | 6.5 | 6.5 | pIC50 | 1 |
Homo sapiens | Vascular endothelial growth factor receptor 2 | 5.4 | 5.4 | 5.5 | pKd | 3 |
Homo sapiens | Vascular endothelial growth factor receptor 2 | 6.6 | 6.6 | 6.6 | pKi | 1 |
Homo sapiens | Vascular endothelial growth factor receptor 3 | 6.6 | 6.6 | 6.6 | pIC50 | 1 |
Homo sapiens | Vascular endothelial growth factor receptor 3 | 5.2 | 5.2 | 5.6 | pKd | 3 |
Homo sapiens | Vascular endothelial growth factor receptor 3 | 6 | 6 | 6 | pKi | 1 |