6CZ2 - chain A (model B) | Protein tyrosine kinase 6
Structure information
PDB:6CZ2
PubMed:29879184
Release date:2018-06-27
Resolution:2.5 Å
 
Kinase:PTK6 (BRK)
Family:Src
Group:TK
Species:HUMAN
 
Quality Score:8
Missing Residues:0
Missing Atoms:0
DFG conformation:in
αC-helix conformation:out
Salt bridge KIII.17 and EαC.24:No (12.7Å)
 
 
ASP rotation (xDFG.81) :321°
PHE rotation (xDFG.82) :321°
Activation loop position:-4.8Å
αC-helix position:21.3Å
 
G-rich loop angle:50.3°
G-rich loop distance:14.6Å
G-rich loop rotation:66.6°
Other models from this PDB:
2D & 3D views

The orthosteric binding pocket
Binding pocket waters
The following waters were found in the defined clusters:
I4
No H-bonds
Binding pocket sequence
UniprotRKLGSGYFGEVFEVAIKVIMLQSEIQAMKKLRKHILALYAVYIITELMAKGSLLELLRDYLESQNYIHRDLAARNILVVGDFGLA
Structure:RKLGSGYFGEVFEVAIKVIMLQSEIQAMKKLRKHILALYAVYIITELMAKGSLLELLRDYLESQNYIHRDLAARNILVVGDFGLA


Modified residues
Residue 342 (not in pocket)
Phosphorylated tyrosine