6C0I - chain B (model B) | V-akt murine thymoma viral oncogene homolog 1

This structure has been superseded by 6NPZ

Structure information
PDB:6C0I
PubMed:30078705
Release date:2018-08-22
Resolution:2.4 Å
 
Kinase:AKT1
Family:Akt
Group:AGC
Species:HUMAN
 
Quality Score:8
Missing Residues:0
Missing Atoms:0
DFG conformation:in
αC-helix conformation:in
Salt bridge KIII.17 and EαC.24:Yes (2.6Å)
 
 
ASP rotation (xDFG.81) :340°
PHE rotation (xDFG.82) :
Activation loop position:-3.9Å
αC-helix position:17.6Å
 
G-rich loop angle:59.6°
G-rich loop distance:17.9Å
G-rich loop rotation:60.9°
Other models from this PDB:
2D & 3D views

The orthosteric binding pocket
Binding pocket waters
The following waters were found in the defined clusters:
I1
H-bond protein
I5
H-bond protein
Binding pocket sequence
UniprotKLLGKGTFGKVILYAMKILHTLTENRVLQNSRPFLTALKYSCFVMEYANGGELFFHLSRLHSEKNVVYRDLKLENLMLITDFGLC
Structure:KLLGKGTFGKVILYAMKILHTLTENRVLQNSRPFLTALKYSCFVMEYANGGELFFHLSRLHSEKNVVYRDLKLENLMLITDFGLC


Modified residues
Residue 308 (not in pocket)
Phosphorylated threonine
Residue 473 (not in pocket)
Phosphorylated serine
Residue 477 (not in pocket)
Phosphorylated serine