6I2Y - chain A | Serine/threonine kinase 10
Structure information
| PDB: | 6I2Y |
| PubMed: | - |
| Release date: | 2018-12-12 |
| Resolution: | 2.56 Å |
| Kinase: | STK10 (LOK) |
| Family: | STE20 |
| Group: | STE |
| Species: | HUMAN |
| Quality Score: | 8 |
| Missing Residues: | 0 |
| Missing Atoms: | 25 |
| DFG conformation: | out |
| αC-helix conformation: | in |
| Salt bridge KIII.17 and EαC.24: | No (9.7Å) |
| ASP rotation (xDFG.81) : | 178° |
| PHE rotation (xDFG.82) : | 183° |
| Activation loop position: | 1.8Å |
| αC-helix position: | 19.1Å |
| G-rich loop angle: | 55.1° |
| G-rich loop distance: | 17.2Å |
| G-rich loop rotation: | 44.3° |
Other models from this PDB:
2D & 3D views
Binding pocket waters
No waters were found in the defined clusters
Binding pocket sequence
| Uniprot | GELGDGAFGKVYKAAAKVIDYIVEIEILATCDPYIVKLLGAWIMIEFCPGGAVDAIMLEFLHSKRIIHRDLKAGNVLMLADFGVS |
| Structure: | GELGDGAFGKVYKAAAKVIDYIVEIEILATCDPYIVKLLGAWIMIEFCPGGAVDAIMLEFLHSKRIIHRDLKAGNVLMLADFGVS |
Modified residues
No modified residues identified.
Orthosteric ligand
Ligand HET-code: 88Z
Ligand Name: N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
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- LABELS
- KLIFS residue #
- Amino Acid
- None
- COLORS
- Interaction types
- KLIFS (all res.)
- KLIFS (interacting res.)
- None
- OTHER
- Show/hide non-interacting res.
- En/disable resizing interacting res.
This ligand targets the following (sub)pockets:
| Main pockets | |
|---|---|
| Front | |
| Gate | |
| Back | |
| Subpockets | |
|---|---|
| FP-I | |
| FP-II | |
| BP-I-A | |
| BP-I-B | |
| BP-II-in | |
| BP-II-A-in | |
| BP-II-B-in | |
| BP-II-out | |
| BP-II-B | |
| BP-III | |
| BP-IV | |
| BP-V | |
Kinase-ligand interactions
■ Hydrophobic ♦ Aromatic face-to-face ♦ Aromatic face-to-edge ▲ H-bond donor ▲ H-bond acceptor ● Ionic positive ● Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 G 40 | 2 E 41 | 3 L 42 | 4 G 43 | 5 D 44 | 6 G 45 | 7 A 46 | 8 F 47 | 9 G 48 | 10 K 49 | 11 V 50 | 12 Y 51 | 13 K 52 | 14 A 62 | 15 A 63 | 16 A 64 | 17 K 65 | 18 V 66 | 19 I 67 | 20 D 77 |
| ■ | ■ | ■ | ■ | ||||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 Y 78 | 22 I 79 | 23 V 80 | 24 E 81 | 25 I 82 | 26 E 83 | 27 I 84 | 28 L 85 | 29 A 86 | 30 T 87 | 31 C 88 | 32 D 89 | 33 P 91 | 34 Y 92 | 35 I 93 | 36 V 94 | 37 K 95 | 38 L 96 | 39 L 97 | 40 G 98 |
| ■ | ■ | ■ | |||||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 A 99 | 42 W 107 | 43 I 108 | 44 M 109 | 45 I 110 | 46 E 111 | 47 F 112 | 48 C 113 | 49 P 114 | 50 G 115 | 51 G 116 | 52 A 117 | 53 V 118 | 54 D 119 | 55 A 120 | 56 I 121 | 57 M 122 | 58 L 123 | 59 E 124 | 60 F 147 |
| ■ | ■ | ■ | ■▲ | ■ | ■ | ■ | |||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 148 | 62 H 149 | 63 S 150 | 64 K 151 | 65 R 152 | 66 I 153 | 67 I 154 | 68 H 155 | 69 R 156 | 70 D 157 | 71 L 158 | 72 K 159 | 73 A 160 | 74 G 161 | 75 N 162 | 76 V 163 | 77 L 164 | 78 M 165 | 79 L 173 | 80 A 174 |
| ■ | ■♦ | ■ | ■ | ■ | |||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 175 | 82 F 176 | 83 G 177 | 84 V 178 | 85 S 179 | |||||||||||||||
| ■▲ | ■♦ | ||||||||||||||||||
Binding affinities
ChEMBL ID:CHEMBL1230609Bioaffinities: 397 records for 194 kinase(s)
| Species | Kinase (ChEMBL naming) | Median | Min | Max | Type | Records |
|---|---|---|---|---|---|---|
| Homo sapiens | ALK tyrosine kinase receptor | 5.5 | 5.5 | 5.5 | pIC50 | 1 |
| Homo sapiens | ALK tyrosine kinase receptor | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | AMP-activated protein kinase, alpha-1 subunit | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | AMP-activated protein kinase, alpha-2 subunit | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Ankyrin repeat and protein kinase domain-containing protein 1 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Breakpoint cluster region protein | 7 | 7 | 7 | pKd | 2 |
| Plasmodium falciparum | Calcium-dependent protein kinase 1 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | CaM kinase I alpha | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | CaM kinase I delta | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | CaM-kinase kinase alpha | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | CaM-kinase kinase beta | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Casein kinase I epsilon | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Casein kinase II alpha (prime) | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Cell division cycle 2-like protein kinase 6 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Cell division protein kinase 8 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Citron Rho-interacting kinase | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | c-Jun N-terminal kinase 1 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | c-Jun N-terminal kinase 2 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | c-Jun N-terminal kinase 3 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 13 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 7 | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 9 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase-like 2 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase-like 3 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase-like 5 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Death-associated protein kinase 3 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Discoidin domain-containing receptor 2 | 6.7 | 6.7 | 8.4 | pKd | 2 |
| Homo sapiens | Dual serine/threonine and tyrosine protein kinase | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | 5.4 | 5.4 | 7.9 | pKd | 2 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 2 | 6 | 6 | 7.9 | pKd | 2 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 5 | 6.8 | 6.8 | 8.6 | pKd | 2 |
| Homo sapiens | Dual specificity protein kinase CLK4 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase TTK | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Dual specificity testis-specific protein kinase 1 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Dual specificty protein kinase CLK1 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 1 | 5.8 | 5.8 | 8.2 | pKd | 2 |
| Homo sapiens | Ephrin type-A receptor 2 | 7.2 | 7.2 | 8.4 | pKd | 2 |
| Homo sapiens | Ephrin type-A receptor 3 | 9 | 9 | 9 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 4 | 6 | 6 | 8.7 | pKd | 2 |
| Homo sapiens | Ephrin type-A receptor 5 | 6.7 | 6.7 | 8.2 | pKd | 2 |
| Homo sapiens | Ephrin type-A receptor 6 | 9 | 9 | 9 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 7 | 8.3 | 8.3 | 8.6 | pKd | 2 |
| Homo sapiens | Ephrin type-A receptor 8 | 8.7 | 8.7 | 8.7 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 1 | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 2 | 5.3 | 5.3 | 8.4 | pKd | 2 |
| Homo sapiens | Ephrin type-B receptor 3 | 5.2 | 5.2 | 7.1 | pKd | 2 |
| Homo sapiens | Ephrin type-B receptor 4 | 6.1 | 6.1 | 7.9 | pKd | 2 |
| Homo sapiens | Ephrin type-B receptor 6 | 6.2 | 6.2 | 8.9 | pKd | 2 |
| Homo sapiens | Epidermal growth factor receptor erbB1 | 5.5 | 5.5 | 5.5 | pIC50 | 4 |
| Homo sapiens | Epidermal growth factor receptor erbB1 | 6.5 | 5.8 | 7.1 | pKd | 12 |
| Homo sapiens | Epithelial discoidin domain-containing receptor 1 | 9.7 | 7.2 | 9.7 | pKd | 3 |
| Homo sapiens | Eukaryotic translation initiation factor 2-alpha kinase 1 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 3 | 5.8 | 5.8 | 6 | pKd | 2 |
| Homo sapiens | Focal adhesion kinase 1 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Hepatocyte growth factor receptor | 8.8 | 6.7 | 9.4 | pIC50 | 50 |
| Homo sapiens | Hepatocyte growth factor receptor | 8.9 | 7 | 9.1 | pKd | 4 |
| Homo sapiens | Homeodomain-interacting protein kinase 1 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 2 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 3 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 4 | 9.3 | 9.3 | 9.3 | pKd | 1 |
| Homo sapiens | Hormonally up-regulated neu tumor-associated kinase | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Inhibitor of nuclear factor kappa B kinase alpha subunit | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Inhibitor of nuclear factor kappa B kinase epsilon subunit | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Insulin-like growth factor I receptor | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Insulin receptor | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Insulin receptor-related protein | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 3 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Leukocyte tyrosine kinase receptor | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | LIM domain kinase 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | LIM domain kinase 2 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Macrophage colony stimulating factor receptor | 8.7 | 8.7 | 8.7 | pKd | 1 |
| Homo sapiens | Macrophage-stimulating protein receptor | 8.5 | 8.5 | 8.5 | pIC50 | 7 |
| Homo sapiens | Macrophage-stimulating protein receptor | 7 | 7 | 8.5 | pKd | 2 |
| Homo sapiens | MAP kinase-interacting serine/threonine-protein kinase MNK1 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | MAP kinase p38 alpha | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | MAP kinase p38 beta | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | MAP kinase p38 delta | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | MAP kinase p38 gamma | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | MAP kinase signal-integrating kinase 2 | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Maternal embryonic leucine zipper kinase | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Misshapen-like kinase 1 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase 15 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 10 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 11 | 6.5 | 6.5 | 6.5 | pKd | 2 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 12 | 7.7 | 7.7 | 7.7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 13 | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 3 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 4 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 7 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 9 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 1 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 3 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 4 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 5 | 6.3 | 6.3 | 8.4 | pKd | 2 |
| Homo sapiens | Mixed lineage kinase 7 | 7.3 | 7.3 | 7.4 | pKd | 2 |
| Homo sapiens | Muscle, skeletal receptor tyrosine protein kinase | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Myosin IIIA | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Myosin-IIIB | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Myosin light chain kinase | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | myosin light chain kinase 2 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Nerve growth factor receptor Trk-A | 7.3 | 7.3 | 8.3 | pKd | 2 |
| Homo sapiens | Neurotrophic tyrosine kinase receptor type 2 | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Non-receptor tyrosine-protein kinase TNK1 | 5.6 | 5.6 | 7.7 | pKd | 2 |
| Homo sapiens | NT-3 growth factor receptor | 8.5 | 8.5 | 8.5 | pKd | 1 |
| Homo sapiens | Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma | 7 | 7 | 7.6 | pKd | 2 |
| Homo sapiens | PITSLRE serine/threonine-protein kinase CDC2L1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | PITSLRE serine/threonine-protein kinase CDC2L2 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor alpha | 8.3 | 8.2 | 8.4 | pIC50 | 4 |
| Homo sapiens | Platelet-derived growth factor receptor alpha | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor beta | 8 | 8 | 8 | pIC50 | 3 |
| Homo sapiens | Platelet-derived growth factor receptor beta | 9 | 9 | 9 | pKd | 1 |
| Homo sapiens | Protein kinase C nu | 5.1 | 5.1 | 5.1 | pKd | 1 |
| Homo sapiens | Protein tyrosine kinase 2 beta | 6.2 | 6.2 | 7.9 | pKd | 2 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase MER | 9.6 | 9.6 | 9.6 | pKd | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase ROS | 8 | 8 | 8 | pIC50 | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase ROS | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase ROS | 7.8 | 7.7 | 8.1 | pKi | 3 |
| Homo sapiens | Receptor-interacting serine/threonine-protein kinase 1 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Receptor-interacting serine/threonine-protein kinase 3 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Receptor-interacting serine/threonine-protein kinase 4 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Receptor protein-tyrosine kinase erbB-2 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Receptor protein-tyrosine kinase erbB-4 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Receptor tyrosine-protein kinase erbB-3 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Rho-associated protein kinase 2 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Ribosomal protein S6 kinase 1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 2 | 5.3 | 5.3 | 5.3 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase 10 | 9.3 | 9.3 | 9.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 2 | 8.5 | 8.5 | 8.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 25 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 33 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 35 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 36 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-A | 5.9 | 5.8 | 6.4 | pKd | 3 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-B | 6.6 | 6.6 | 7.4 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-C | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase B-raf | 5.5 | 5.5 | 5.6 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase Chk2 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MAK | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MRCK-A | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MRCK beta | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MRCK gamma | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST1 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase NEK9 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Serine/threonine protein kinase NLK | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 3 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-1 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-2 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-3 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PFTAIRE-1 | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PFTAIRE-2 | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK4 | 7 | 7 | 8.5 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase RAF | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RIPK2 | 7.3 | 7.3 | 7.7 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase SIK1 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK2 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TAO1 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TAO2 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TBK1 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TNNI3K | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase ULK3 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | SPS1/STE20-related protein kinase YSK4 | 8.3 | 8.3 | 8.3 | pKd | 1 |
| Homo sapiens | Stem cell growth factor receptor | 8.2 | 8.2 | 8.4 | pIC50 | 7 |
| Homo sapiens | Stem cell growth factor receptor | 8.5 | 7.4 | 8.7 | pKd | 8 |
| Homo sapiens | TRAF2- and NCK-interacting kinase | 5.4 | 5.4 | 6.7 | pKd | 2 |
| Homo sapiens | Tyrosine kinase non-receptor protein 2 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase ABL | 7.3 | 6.5 | 8.4 | pKd | 16 |
| Homo sapiens | Tyrosine-protein kinase ABL2 | 7.3 | 7.3 | 7.6 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase BLK | 8.3 | 8.3 | 8.3 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BMX | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BRK | 6.4 | 6.4 | 8.4 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase BTK | 6.4 | 6.4 | 7.1 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase CSK | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FER | 6.4 | 6.4 | 7.4 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase FES | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FGR | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FRK | 7.6 | 7.6 | 8.4 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase FYN | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase HCK | 7.2 | 7.2 | 7.8 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase ITK/TSK | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase JAK2 | 5.8 | 5.8 | 5.8 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase LCK | 7.4 | 7.4 | 8.2 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase Lyn | 7 | 7 | 8 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 8.3 | 8.3 | 8.4 | pIC50 | 7 |
| Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 8.8 | 7.2 | 9.1 | pKd | 9 |
| Homo sapiens | Tyrosine-protein kinase receptor RET | 8.8 | 8.2 | 9.2 | pKd | 5 |
| Homo sapiens | Tyrosine-protein kinase receptor Tie-1 | 9.1 | 9.1 | 9.1 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor TYRO3 | 8.7 | 8.7 | 8.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor UFO | 8 | 8 | 8 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor UFO | 10 | 10 | 10 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase SRC | 7.6 | 7.6 | 7.7 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase Srms | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase SYK | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TEC | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TIE-2 | 9 | 9 | 9 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase TIE-2 | 8.5 | 8.5 | 8.5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TXK | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TYK2 | 5.3 | 5.3 | 5.3 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase YES | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | 8.2 | 8.1 | 9.1 | pIC50 | 4 |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 9.1 | 7.8 | 9.1 | pIC50 | 15 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 3 | 8.6 | 8.6 | 8.6 | pIC50 | 3 |
| Homo sapiens | Vascular endothelial growth factor receptor 3 | 8.8 | 8.8 | 8.8 | pKd | 1 |