1XBA - chain A | Spleen tyrosine kinase
Structure information
| PDB: | 1XBA |
| PubMed: | 15507431 |
| Release date: | 2004-11-02 |
| Resolution: | 2 Å |
| Kinase: | SYK |
| Family: | Syk |
| Group: | TK |
| Species: | HUMAN |
| Quality Score: | 8.3 |
| Missing Residues: | 0 |
| Missing Atoms: | 17 |
| DFG conformation: | in |
| αC-helix conformation: | in |
| Salt bridge KIII.17 and EαC.24: | Yes (3.3Å) |
| ASP rotation (xDFG.81) : | 344° |
| PHE rotation (xDFG.82) : | 15° |
| Activation loop position: | -3.6Å |
| αC-helix position: | 17.9Å |
| G-rich loop angle: | 57.2° |
| G-rich loop distance: | 17.6Å |
| G-rich loop rotation: | 74.1° |
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I4
H-bond protein
I6
H-bond protein
Binding pocket sequence
| Uniprot | KELGSGNFGTVKKVAVKILELLAEANVMQQLDPYIVRMIGIMLVMEMAELGPLNKYLQQYLEESNFVHRDLAARNVLLISDFGLS |
| Structure: | KELGSGNFGTVKKVAVKILELLAEANVMQQLDPYIVRMIGIMLVMEMAELGPLNKYLQQYLEESNFVHRDLAARNVLLISDFGLS |
Modified residues
No modified residues identified.