4PWN - chain A | WNK lysine deficient protein kinase 1
Structure information
| PDB: | 4PWN |
| PubMed: | 24803536 |
| Release date: | 2014-05-28 |
| Resolution: | 1.84 Å |
| Kinase: | WNK1 (Wnk1) |
| Family: | WNK |
| Group: | Other |
| Species: | HUMAN |
| Quality Score: | 7.6 |
| Missing Residues: | 1 |
| Missing Atoms: | 0 |
| DFG conformation: | in |
| αC-helix conformation: | out |
| Salt bridge KIII.17 and EαC.24: | No |
| ASP rotation (xDFG.81) : | 310° |
| PHE rotation (xDFG.82) : | 344° |
| Activation loop position: | -3.4Å |
| αC-helix position: | 20.9Å |
| G-rich loop angle: | 60.4° |
| G-rich loop distance: | 17.2Å |
| G-rich loop rotation: | 14.1° |
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I3
H-bond protein
I4
H-bond protein
I5
H-bond protein
Binding pocket sequence
| Uniprot | IEIGRGSFKTVYKVAWCELRFKEEAEMLKGLQPNIVRFYDSVLVTELMTSGTLKTYLKRHTRTPPIIHRDLKCDNIFIIGDLGLA |
| Structure: | IEIGRGSFKTVYKVAWCEL_FKEEAEMLKGLQPNIVRFYDSVLVTELMTSGTLKTYLKRHTRTPPIIHRDLKCDNIFIIGDLGLA |
Modified residues
No modified residues identified.