3ZBF - chain A | ROS proto-oncogene 1 , receptor tyrosine kinase
Structure information
PDB: | 3ZBF |
PubMed: | 23724914 |
Release date: | 2013-06-12 |
Resolution: | 2.2 Å |
Kinase: | ROS1 (ROS) |
Family: | Sev |
Group: | TK |
Species: | HUMAN |
Quality Score: | 6.8 |
Missing Residues: | 3 |
Missing Atoms: | 0 |
DFG conformation: | in |
αC-helix conformation: | in |
Salt bridge KIII.17 and EαC.24: | Yes (3.5Å) |
ASP rotation (xDFG.81) : | 9° |
PHE rotation (xDFG.82) : | 14° |
Activation loop position: | -4.2Å |
αC-helix position: | 17Å |
G-rich loop angle: | - |
G-rich loop distance: | - |
G-rich loop rotation: | - |
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I4
H-bond protein
I5
H-bond protein
Binding pocket sequence
Uniprot | LLLGSGAFGEVYEVAVKTLEFLKEAHLMSKFNPNILKQLGVYIILELMEGGDLLTYLRKYLERMHFIHRDLAARNCLVIGDFGLA |
Structure: | LLLGSG___EVYEVAVKTLEFLKEAHLMSKFNPNILKQLGVYIILELMEGGDLLTYLRKYLERMHFIHRDLAARNCLVIGDFGLA |
Modified residues
No modified residues identified.
Orthosteric ligand
Ligand HET-code: VGH
Ligand Name: 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine
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- LABELS
- KLIFS residue #
- Amino Acid
- None
- COLORS
- Interaction types
- KLIFS (all res.)
- KLIFS (interacting res.)
- None
- OTHER
- Show/hide non-interacting res.
- En/disable resizing interacting res.
This ligand targets the following (sub)pockets:
Main pockets | |
---|---|
Front | |
Gate | |
Back |
Subpockets | |
---|---|
FP-I | |
FP-II | |
BP-I-A | |
BP-I-B | |
BP-II-in | |
BP-II-A-in | |
BP-II-B-in | |
BP-II-out | |
BP-II-B | |
BP-III | |
BP-IV | |
BP-V |
Kinase-ligand interactions
■ Hydrophobic ♦ Aromatic face-to-face ♦ Aromatic face-to-edge ▲ H-bond donor ▲ H-bond acceptor ● Ionic positive ● Ionic negative
I | g.l | II | III | αC | |||||||||||||||
1 L 1949 | 2 L 1950 | 3 L 1951 | 4 G 1952 | 5 S 1953 | 6 G 1957 | 7 _ _ | 8 _ _ | 9 _ _ | 10 E 1958 | 11 V 1959 | 12 Y 1960 | 13 E 1961 | 14 V 1977 | 15 A 1978 | 16 V 1979 | 17 K 1980 | 18 T 1981 | 19 L 1982 | 20 E 1993 |
■ | ■ | ■ | ■ | ||||||||||||||||
αC | b.l | IV | |||||||||||||||||
21 F 1994 | 22 L 1995 | 23 K 1996 | 24 E 1997 | 25 A 1998 | 26 H 1999 | 27 L 2000 | 28 M 2001 | 29 S 2002 | 30 K 2003 | 31 F 2004 | 32 N 2005 | 33 P 2007 | 34 N 2008 | 35 I 2009 | 36 L 2010 | 37 K 2011 | 38 Q 2012 | 39 L 2013 | 40 G 2014 |
■ | |||||||||||||||||||
IV | V | GK | hinge | linker | αD | αE | |||||||||||||
41 V 2015 | 42 Y 2023 | 43 I 2024 | 44 I 2025 | 45 L 2026 | 46 E 2027 | 47 L 2028 | 48 M 2029 | 49 E 2030 | 50 G 2031 | 51 G 2032 | 52 D 2033 | 53 L 2034 | 54 L 2035 | 55 T 2036 | 56 Y 2037 | 57 L 2038 | 58 R 2039 | 59 K 2040 | 60 Y 2069 |
■ | ▲ | ■ | ■▲ | ■ | ■ | ||||||||||||||
αE | VI | c.l | VII | VIII | x | ||||||||||||||
61 L 2070 | 62 E 2071 | 63 R 2072 | 64 M 2073 | 65 H 2074 | 66 F 2075 | 67 I 2076 | 68 H 2077 | 69 R 2078 | 70 D 2079 | 71 L 2080 | 72 A 2081 | 73 A 2082 | 74 R 2083 | 75 N 2084 | 76 C 2085 | 77 L 2086 | 78 V 2087 | 79 I 2100 | 80 G 2101 |
■ | ■ | ■ | ■ | ||||||||||||||||
DFG | a.l | ||||||||||||||||||
81 D 2102 | 82 F 2103 | 83 G 2104 | 84 L 2105 | 85 A 2106 | |||||||||||||||
■ |
Binding affinities
ChEMBL ID:CHEMBL601719Bioaffinities: 368 records for 154 kinase(s)
Species | Kinase (ChEMBL naming) | Median | Min | Max | Type | Records |
---|---|---|---|---|---|---|
Homo sapiens | Activin receptor type-1 | 6.4 | 6.4 | 6.4 | pKd | 1 |
Homo sapiens | Activin receptor type-1B | 6.1 | 6.1 | 6.1 | pKd | 1 |
Homo sapiens | Adaptor-associated kinase | 5.6 | 5.6 | 5.6 | pKd | 1 |
Homo sapiens | ALK tyrosine kinase receptor | 5.7 | 4.6 | 9.3 | pEC50 | 4 |
Homo sapiens | ALK tyrosine kinase receptor | 6.9 | 4.5 | 9.2 | pIC50 | 68 |
Homo sapiens | ALK tyrosine kinase receptor | 8.5 | 8.4 | 8.5 | pKd | 3 |
Homo sapiens | ALK tyrosine kinase receptor | 8.1 | 8.1 | 9.1 | pKi | 5 |
Mus musculus | ALK tyrosine kinase receptor | 7.1 | 7.1 | 7.1 | pIC50 | 1 |
Homo sapiens | AMP-activated protein kinase, alpha-1 subunit | 5.6 | 5.6 | 5.6 | pKd | 1 |
Homo sapiens | Ankyrin repeat and protein kinase domain-containing protein 1 | 6.1 | 6.1 | 6.1 | pKd | 1 |
Homo sapiens | BMP-2-inducible protein kinase | 6.1 | 6.1 | 6.1 | pKd | 1 |
Homo sapiens | Bone morphogenetic protein receptor type-1B | 6.6 | 6.6 | 6.6 | pKd | 1 |
Homo sapiens | Breakpoint cluster region protein | 5.6 | 5.6 | 5.6 | pKd | 2 |
Homo sapiens | CaM-kinase kinase beta | 5.8 | 5.8 | 5.8 | pKd | 1 |
Homo sapiens | Cyclin-dependent kinase 7 | 6.5 | 6.5 | 6.5 | pKd | 1 |
Homo sapiens | Cyclin-dependent kinase-like 2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
Homo sapiens | Dual serine/threonine and tyrosine protein kinase | 6.4 | 6.4 | 6.4 | pKd | 1 |
Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 3 | 5.5 | 5.5 | 5.5 | pKd | 1 |
Homo sapiens | Dual specificity testis-specific protein kinase 1 | 6.4 | 6.4 | 6.4 | pKd | 1 |
Homo sapiens | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 5.4 | 5.4 | 5.4 | pKd | 1 |
Homo sapiens | Ephrin type-A receptor 1 | 6.9 | 6.9 | 6.9 | pKd | 1 |
Homo sapiens | Ephrin type-A receptor 2 | 5.9 | 5.9 | 7 | pKd | 2 |
Homo sapiens | Ephrin type-A receptor 3 | 6.2 | 6.2 | 6.2 | pKd | 1 |
Homo sapiens | Ephrin type-A receptor 4 | 6.4 | 6.4 | 6.4 | pKd | 1 |
Homo sapiens | Ephrin type-A receptor 5 | 6 | 6 | 6 | pKd | 1 |
Homo sapiens | Ephrin type-A receptor 6 | 7.2 | 7.2 | 7.2 | pKd | 1 |
Homo sapiens | Ephrin type-A receptor 7 | 6.3 | 6.3 | 6.3 | pKd | 1 |
Homo sapiens | Ephrin type-A receptor 8 | 6.6 | 6.6 | 6.6 | pKd | 1 |
Homo sapiens | Ephrin type-B receptor 1 | 6.9 | 6.9 | 6.9 | pKd | 1 |
Homo sapiens | Ephrin type-B receptor 4 | 6.2 | 6.2 | 6.2 | pKd | 1 |
Homo sapiens | Ephrin type-B receptor 6 | 6.3 | 6.3 | 8.2 | pKd | 2 |
Homo sapiens | Epidermal growth factor receptor erbB1 | 6.2 | 6.2 | 6.2 | pIC50 | 1 |
Homo sapiens | Epidermal growth factor receptor erbB1 | 5.6 | 5.6 | 5.6 | pKd | 2 |
Homo sapiens | Epithelial discoidin domain-containing receptor 1 | 6.3 | 6.3 | 6.3 | pKd | 1 |
Homo sapiens | Fibroblast growth factor receptor 3 | 5.5 | 5.5 | 5.6 | pKd | 2 |
Homo sapiens | Focal adhesion kinase 1 | 6.2 | 6.2 | 6.5 | pKd | 2 |
Homo sapiens | G protein-coupled receptor kinase 4 | 5.4 | 5.4 | 5.4 | pKd | 1 |
Homo sapiens | Hepatocyte growth factor receptor | 8.5 | 7.7 | 9.3 | pIC50 | 27 |
Homo sapiens | Hepatocyte growth factor receptor | 8.7 | 8.1 | 9.7 | pKd | 6 |
Homo sapiens | Hepatocyte growth factor receptor | 8.7 | 8.4 | 8.7 | pKi | 3 |
Homo sapiens | Homeodomain-interacting protein kinase 4 | 5.4 | 5.4 | 5.4 | pKd | 1 |
Homo sapiens | Inhibitor of nuclear factor kappa B kinase beta subunit | 5.3 | 5.3 | 5.3 | pKd | 1 |
Homo sapiens | Inhibitor of nuclear factor kappa B kinase epsilon subunit | 5.6 | 5.6 | 6.2 | pKd | 2 |
Homo sapiens | Insulin-like growth factor I receptor | 6.8 | 6.8 | 6.8 | pIC50 | 1 |
Homo sapiens | Insulin-like growth factor I receptor | 6.1 | 6.1 | 6.1 | pKd | 1 |
Homo sapiens | Insulin receptor | 6.2 | 5.5 | 7 | pIC50 | 5 |
Homo sapiens | Insulin receptor | 6.5 | 6.5 | 6.5 | pKd | 1 |
Homo sapiens | Insulin receptor-related protein | 6.2 | 6.2 | 6.2 | pKd | 1 |
Homo sapiens | Interferon-induced, double-stranded RNA-activated protein kinase | 6 | 6 | 6 | pKd | 1 |
Homo sapiens | Interleukin-1 receptor-associated kinase 1 | 5.4 | 5.4 | 7.3 | pKd | 2 |
Homo sapiens | Interleukin-1 receptor-associated kinase 3 | 6.2 | 6.2 | 7.5 | pKd | 2 |
Homo sapiens | Interleukin-1 receptor-associated kinase 4 | 5.4 | 5.4 | 5.4 | pKd | 1 |
Homo sapiens | Leukocyte tyrosine kinase receptor | 7.9 | 7.9 | 7.9 | pKd | 1 |
Homo sapiens | LIM domain kinase 1 | 5.7 | 5.7 | 6.1 | pKd | 2 |
Homo sapiens | LIM domain kinase 2 | 5.4 | 5.4 | 6.2 | pKd | 2 |
Homo sapiens | Macrophage colony stimulating factor receptor | 6.7 | 6.7 | 6.7 | pKd | 1 |
Homo sapiens | Macrophage-stimulating protein receptor | 6.5 | 6.5 | 6.7 | pIC50 | 2 |
Homo sapiens | Macrophage-stimulating protein receptor | 7.1 | 7.1 | 7.6 | pKd | 2 |
Mus musculus | Macrophage-stimulating protein receptor | 7.1 | 7.1 | 7.1 | pIC50 | 1 |
Homo sapiens | Misshapen-like kinase 1 | 5.4 | 5.4 | 5.4 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase 7 | 6.3 | 6.3 | 6.3 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 1 | 5.7 | 5.7 | 6 | pKd | 2 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 12 | 6.8 | 6.8 | 6.8 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 13 | 6.6 | 6.6 | 6.6 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 15 | 5.6 | 5.6 | 5.6 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 2 | 7.1 | 7.1 | 7.1 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 3 | 7 | 7 | 7 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 7 | 5.8 | 5.8 | 5.8 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 1 | 5.7 | 5.7 | 7.4 | pKd | 2 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 2 | 6.7 | 6.7 | 7.1 | pKd | 2 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 3 | 5.6 | 5.6 | 7.1 | pKd | 2 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 5 | 6 | 6 | 7.1 | pKd | 2 |
Homo sapiens | Mixed lineage kinase domain-like protein | 6.7 | 6.7 | 6.7 | pKd | 1 |
Homo sapiens | Muscle, skeletal receptor tyrosine protein kinase | 6.6 | 6.6 | 6.6 | pKd | 1 |
Homo sapiens | Myotonin-protein kinase | 5.9 | 5.9 | 5.9 | pKd | 1 |
Homo sapiens | Nerve growth factor receptor Trk-A | 6.2 | 6.2 | 6.2 | pIC50 | 1 |
Homo sapiens | Nerve growth factor receptor Trk-A | 7 | 7 | 7 | pKd | 1 |
Homo sapiens | Neurotrophic tyrosine kinase receptor type 2 | 6.4 | 6.4 | 8.7 | pIC50 | 2 |
Homo sapiens | Neurotrophic tyrosine kinase receptor type 2 | 7.4 | 7.4 | 7.4 | pKd | 1 |
Homo sapiens | Non-receptor tyrosine-protein kinase TNK1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
Homo sapiens | NT-3 growth factor receptor | 7.1 | 7.1 | 7.1 | pKd | 1 |
Homo sapiens | NUAK family SNF1-like kinase 2 | 6.9 | 6.9 | 6.9 | pKd | 1 |
Homo sapiens | Peripheral plasma membrane protein CASK | 6.9 | 6.9 | 6.9 | pKd | 1 |
Homo sapiens | Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha | 5.5 | 5.5 | 5.5 | pKd | 1 |
Homo sapiens | PITSLRE serine/threonine-protein kinase CDC2L1 | 6.1 | 6.1 | 6.1 | pKd | 1 |
Homo sapiens | PITSLRE serine/threonine-protein kinase CDC2L2 | 6.4 | 6.4 | 6.4 | pKd | 1 |
Homo sapiens | Protein kinase C mu | 6 | 6 | 6 | pKd | 1 |
Homo sapiens | Protein kinase C nu | 6.1 | 6.1 | 6.3 | pKd | 2 |
Homo sapiens | Protein tyrosine kinase 2 beta | 6.7 | 6.7 | 6.7 | pKd | 1 |
Homo sapiens | Proto-oncogene tyrosine-protein kinase MER | 8.4 | 8.4 | 8.4 | pKd | 1 |
Homo sapiens | Proto-oncogene tyrosine-protein kinase ROS | 8 | 5.2 | 9.2 | pIC50 | 10 |
Homo sapiens | Proto-oncogene tyrosine-protein kinase ROS | 8.4 | 8.4 | 8.4 | pKd | 1 |
Homo sapiens | Proto-oncogene tyrosine-protein kinase ROS | 8.2 | 6.5 | 9.2 | pKi | 3 |
Homo sapiens | Putative uncharacterized serine/threonine-protein kinase SgK110 | 6.6 | 6.6 | 6.6 | pKd | 1 |
Homo sapiens | Receptor-interacting serine/threonine-protein kinase 1 | 5.8 | 5.8 | 5.9 | pKd | 2 |
Homo sapiens | Receptor-interacting serine/threonine-protein kinase 3 | 5.2 | 5.2 | 5.2 | pKd | 1 |
Homo sapiens | Receptor-interacting serine/threonine-protein kinase 4 | 5.7 | 5.7 | 5.7 | pKd | 1 |
Homo sapiens | Rho-associated protein kinase 1 | 5.4 | 5.4 | 5.4 | pKd | 1 |
Homo sapiens | Rho-associated protein kinase 2 | 5.5 | 5.5 | 5.5 | pKd | 1 |
Homo sapiens | Ribosomal protein S6 kinase 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase 10 | 5.6 | 5.6 | 7.4 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase 2 | 5.9 | 5.9 | 7.8 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase 35 | 6.2 | 6.2 | 6.2 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase Aurora-A | 6.6 | 6.3 | 7.1 | pKd | 3 |
Homo sapiens | Serine/threonine-protein kinase Aurora-B | 5.9 | 5.9 | 7.1 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase Aurora-C | 5.4 | 5.4 | 5.4 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase D2 | 5.2 | 5.2 | 5.2 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase DCLK1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase DCLK2 | 6.4 | 6.4 | 6.4 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase MST1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase MST2 | 6 | 6 | 6 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase MST4 | 5.6 | 5.6 | 5.6 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase NEK7 | 5.2 | 5.2 | 5.2 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase NEK9 | 6.1 | 6.1 | 6.1 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase NIM1 | 5.3 | 5.3 | 5.3 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase PLK4 | 7.2 | 7.2 | 7.2 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase RIO1 | 5.2 | 5.2 | 5.2 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase RIO3 | 5.4 | 5.4 | 5.4 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase RIPK2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase SBK1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase SIK2 | 6.7 | 6.7 | 6.7 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase SRPK1 | 5.8 | 5.8 | 5.8 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase SRPK3 | 5.1 | 5.1 | 5.1 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase TAO1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase TAO2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase TAO3 | 6.3 | 6.3 | 6.3 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase TBK1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase TNNI3K | 7 | 7 | 7 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase ULK1 | 6 | 6 | 6 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase ULK2 | 5.8 | 5.8 | 5.8 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase ULK3 | 5.2 | 5.2 | 5.2 | pKd | 1 |
Homo sapiens | SPS1/STE20-related protein kinase YSK4 | 6 | 6 | 6 | pKd | 1 |
Homo sapiens | Stem cell growth factor receptor | 5.4 | 5.4 | 6.1 | pKd | 2 |
Homo sapiens | TGF-beta receptor type I | 5.5 | 5.5 | 6 | pKd | 2 |
Homo sapiens | Tyrosine kinase non-receptor protein 2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase ABL | 5.9 | 5.9 | 7.6 | pIC50 | 2 |
Homo sapiens | Tyrosine-protein kinase ABL | 7 | 5.5 | 8 | pKd | 16 |
Mus musculus | Tyrosine-protein kinase ABL | 5.9 | 5.9 | 5.9 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase ABL2 | 6.3 | 6.3 | 6.4 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase BLK | 7 | 7 | 7 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase BMX | 5.4 | 5.4 | 5.4 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase BTK | 5.1 | 5.1 | 5.1 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase FER | 6.6 | 6.6 | 6.6 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase FES | 6.4 | 6.4 | 6.4 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase FGR | 6.2 | 6.2 | 6.2 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase FRK | 5.5 | 5.5 | 5.5 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase FYN | 5.9 | 5.9 | 5.9 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase ITK/TSK | 5.7 | 5.7 | 5.7 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase JAK1 | 6.3 | 6.3 | 6.3 | pIC50 | 2 |
Homo sapiens | Tyrosine-protein kinase JAK1 | 6.5 | 6.5 | 6.5 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase JAK2 | 7.6 | 7.6 | 7.6 | pIC50 | 2 |
Homo sapiens | Tyrosine-protein kinase JAK2 | 6.5 | 6.5 | 8 | pKd | 4 |
Homo sapiens | Tyrosine-protein kinase JAK3 | 5.9 | 5.9 | 5.9 | pIC50 | 2 |
Homo sapiens | Tyrosine-protein kinase JAK3 | 6.7 | 6.7 | 6.7 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase LCK | 5.6 | 5.6 | 5.6 | pIC50 | 2 |
Homo sapiens | Tyrosine-protein kinase LCK | 5.9 | 5.9 | 7.5 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase Lyn | 6 | 6 | 6 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 6.1 | 5.5 | 6.7 | pKd | 7 |
Homo sapiens | Tyrosine-protein kinase receptor RET | 5.7 | 5.7 | 5.9 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase receptor Tie-1 | 7 | 7 | 7 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase receptor TYRO3 | 6.1 | 6.1 | 6.1 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase receptor UFO | 6.5 | 6.5 | 6.5 | pIC50 | 3 |
Homo sapiens | Tyrosine-protein kinase receptor UFO | 8.1 | 8.1 | 8.1 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase SRC | 6.3 | 6.3 | 6.3 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase SYK | 5.6 | 5.6 | 5.6 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase TIE-2 | 6.4 | 6.4 | 8.3 | pIC50 | 2 |
Homo sapiens | Tyrosine-protein kinase TIE-2 | 6.6 | 6.6 | 6.6 | pKd | 1 |
Mus musculus | Tyrosine-protein kinase TIE-2 | 6.4 | 6.4 | 6.4 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase TXK | 6.1 | 6.1 | 6.1 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase TYK2 | 5.9 | 5.9 | 5.9 | pIC50 | 2 |
Homo sapiens | Tyrosine-protein kinase TYK2 | 5.7 | 5.7 | 6.7 | pKd | 4 |
Homo sapiens | Tyrosine-protein kinase YES | 6.1 | 6.1 | 6.1 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase ZAP-70 | 5.4 | 5.4 | 5.4 | pKd | 1 |
Homo sapiens | Uncharacterized aarF domain-containing protein kinase 4 | 6 | 6 | 6 | pKd | 1 |
Homo sapiens | Vascular endothelial growth factor receptor 1 | 5.6 | 5.6 | 5.6 | pKd | 1 |