4X2N - chain A (model A) | Transforming growth factor beta receptor I
Structure information
PDB:4X2N
PubMed:25437144
Release date:2014-12-24
Resolution:1.8 Å
 
Kinase:TGFBR1 (TGFbR1)
Family:STKR
Group:TKL
Species:HUMAN
 
Quality Score:8
Missing Residues:0
Missing Atoms:0
DFG conformation:in
αC-helix conformation:in
Salt bridge KIII.17 and EαC.24:Yes (3.1Å)
 
 
ASP rotation (xDFG.81) :335°
PHE rotation (xDFG.82) :356°
Activation loop position:-3.4Å
αC-helix position:17.4Å
 
G-rich loop angle:53.6°
G-rich loop distance:16.1Å
G-rich loop rotation:53°
Other models from this PDB:
2D & 3D views

The orthosteric binding pocket
Binding pocket waters
The following waters were found in the defined clusters:
I1
H-bond protein
I2
H-bond protein
I3
H-bond protein
I5
H-bond protein
I11
No H-bonds
Binding pocket sequence
UniprotESIGKGRFGEVWRVAVKIFSWFREAEIYQTVMENILGFIAAWLVSDYHEHGSLFDYLNRTQGKPAIAHRDLKSKNILVIADLGLA
Structure:ESIGKGRFGEVWRVAVKIFSWFREAEIYQTVMENILGFIAAWLVSDYHEHGSLFDYLNRTQGKPAIAHRDLKSKNILVIADLGLA


Modified residues
No modified residues identified.