4X2N - chain A (model A) | Transforming growth factor beta receptor I
Structure information
PDB: | 4X2N |
PubMed: | 25437144 |
Release date: | 2014-12-24 |
Resolution: | 1.8 Å |
Kinase: | TGFBR1 (TGFbR1) |
Family: | STKR |
Group: | TKL |
Species: | HUMAN |
Quality Score: | 8 |
Missing Residues: | 0 |
Missing Atoms: | 0 |
DFG conformation: | in |
αC-helix conformation: | in |
Salt bridge KIII.17 and EαC.24: | Yes (3.1Å) |
ASP rotation (xDFG.81) : | 335° |
PHE rotation (xDFG.82) : | 356° |
Activation loop position: | -3.4Å |
αC-helix position: | 17.4Å |
G-rich loop angle: | 53.6° |
G-rich loop distance: | 16.1Å |
G-rich loop rotation: | 53° |
Other models from this PDB:
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I1
H-bond protein
I2
H-bond protein
I3
H-bond protein
I5
H-bond protein
I11
No H-bonds
Binding pocket sequence
Uniprot | ESIGKGRFGEVWRVAVKIFSWFREAEIYQTVMENILGFIAAWLVSDYHEHGSLFDYLNRTQGKPAIAHRDLKSKNILVIADLGLA |
Structure: | ESIGKGRFGEVWRVAVKIFSWFREAEIYQTVMENILGFIAAWLVSDYHEHGSLFDYLNRTQGKPAIAHRDLKSKNILVIADLGLA |
Modified residues
No modified residues identified.