1IAS - chain D | Transforming growth factor beta receptor I
Structure information
PDB:1IAS
PubMed:11583628
Release date:2001-10-03
Resolution:2.9 Å
 
Kinase:TGFBR1 (TGFbR1)
Family:STKR
Group:TKL
Species:HUMAN
 
Quality Score:8
Missing Residues:0
Missing Atoms:0
DFG conformation:in
αC-helix conformation:in
Salt bridge KIII.17 and EαC.24:Yes (2.8Å)
 
 
ASP rotation (xDFG.81) :352°
PHE rotation (xDFG.82) :355°
Activation loop position:-3.3Å
αC-helix position:16.9Å
 
G-rich loop angle:48.4°
G-rich loop distance:14.9Å
G-rich loop rotation:67.6°
Other models from this PDB:
2D & 3D views

The orthosteric binding pocket
Binding pocket waters
No waters were found in the defined clusters
Binding pocket sequence
UniprotESIGKGRFGEVWRVAVKIFSWFREAEIYQTVMENILGFIAAWLVSDYHEHGSLFDYLNRTQGKPAIAHRDLKSKNILVIADLGLA
Structure:ESIGKGRFGEVWRVAVKIFSWFREAEIYQTVMENILGFIAAWLVSDYHEHGSLFDYLNRTQGKPAIAHRDLKSKNILVIADLGLA


Modified residues
No modified residues identified.