4I4F - chain A (model C) | Protein tyrosine kinase 2
Structure information
PDB: | 4I4F |
PubMed: | 23414845 |
Release date: | 2013-02-06 |
Resolution: | 1.75 Å |
Kinase: | PTK2 (FAK) |
Family: | FAK |
Group: | TK |
Species: | HUMAN |
Quality Score: | 5.3 |
Missing Residues: | 3 |
Missing Atoms: | 7 |
DFG conformation: | out |
αC-helix conformation: | in |
Salt bridge KIII.17 and EαC.24: | No (6.2Å) |
ASP rotation (xDFG.81) : | 128° |
PHE rotation (xDFG.82) : | 226° |
Activation loop position: | 3Å |
αC-helix position: | 18.1Å |
G-rich loop angle: | 39.1° |
G-rich loop distance: | 13.3Å |
G-rich loop rotation: | 124.9° |
Other models from this PDB:
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I4
H-bond protein
I8
H-bond protein
O1
H-bond protein
Binding pocket sequence
Uniprot | RCIGEGQFGDVHQVAIKTCKFLQEALTMRQFDPHIVKLIGVWIIMELCTLGELRSFLQVYLESKRFVHRDIAARNVLVLGDFGLS |
Structure: | RCIGEGQFGDVHQVAIKTCKFLQEALTMRQFDPHIVKLIGVWIIMELCTGELR__SFLQYLESKRFVHRDIAARNVLVLGDFGL_ |
Modified residues
No modified residues identified.
Allosteric ligand
Ligand HET-code: 1BR
Ligand Name: N-(4-tert-butylbenzyl)-1,5-dimethyl-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazin-8-amine 4,4-dioxide
Binding affinities
Ligand not found in ChEMBL.