4AE9 - chain A (model A) | Protein kinase cAMP-activated catalytic subunit alpha
Structure information
PDB: | 4AE9 |
PubMed: | 22504716 |
Release date: | 2012-04-18 |
Resolution: | 2.3 Å |
Kinase: | PRKACA (PKACa) |
Family: | PKA |
Group: | AGC |
Species: | HUMAN |
Quality Score: | 8 |
Missing Residues: | 0 |
Missing Atoms: | 0 |
DFG conformation: | in |
αC-helix conformation: | in |
Salt bridge KIII.17 and EαC.24: | No (4.9Å) |
ASP rotation (xDFG.81) : | 3° |
PHE rotation (xDFG.82) : | 13° |
Activation loop position: | -4.9Å |
αC-helix position: | 18.8Å |
G-rich loop angle: | 70.3° |
G-rich loop distance: | 20.6Å |
G-rich loop rotation: | 80.6° |
Other models from this PDB:
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I4
H-bond protein
I6
H-bond protein
Binding pocket sequence
Uniprot | KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVPGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA |
Structure: | KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVPGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA |
Modified residues
Residue 139 (not in pocket)
Phosphorylated serine
Residue 197 (not in pocket)
Phosphorylated threonine
Residue 338 (not in pocket)
Phosphorylated serine