4AE6 - chain A (model A) | Protein kinase cAMP-activated catalytic subunit alpha
Structure information
| PDB: | 4AE6 |
| PubMed: | 22504716 |
| Release date: | 2012-04-18 |
| Resolution: | 2.1 Å |
| Kinase: | PRKACA (PKACa) |
| Family: | PKA |
| Group: | AGC |
| Species: | HUMAN |
| Quality Score: | 8 |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| DFG conformation: | in |
| αC-helix conformation: | in |
| Salt bridge KIII.17 and EαC.24: | Yes (3Å) |
| ASP rotation (xDFG.81) : | 0° |
| PHE rotation (xDFG.82) : | 13° |
| Activation loop position: | -4.7Å |
| αC-helix position: | 18.8Å |
| G-rich loop angle: | 69.7° |
| G-rich loop distance: | 20.5Å |
| G-rich loop rotation: | 79.7° |
Other models from this PDB:
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I4
H-bond protein
Binding pocket sequence
| Uniprot | KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVPGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA |
| Structure: | KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVPGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA |
Modified residues
Residue 197 (not in pocket)
Phosphorylated threonine
Residue 338 (not in pocket)
Phosphorylated serine