3AGM - chain A | Protein kinase cAMP-activated catalytic subunit alpha
Structure information
| PDB: | 3AGM |
| PubMed: | 20732331 |
| Release date: | 2010-09-01 |
| Resolution: | 2 Å |
| Kinase: | PRKACA (PKACa) |
| Family: | PKA |
| Group: | AGC |
| Species: | HUMAN |
| Quality Score: | 8 |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| DFG conformation: | in |
| αC-helix conformation: | in |
| Salt bridge KIII.17 and EαC.24: | Yes (2.8Å) |
| ASP rotation (xDFG.81) : | 342° |
| PHE rotation (xDFG.82) : | 6° |
| Activation loop position: | -4.1Å |
| αC-helix position: | 17.8Å |
| G-rich loop angle: | 57.9° |
| G-rich loop distance: | 17.9Å |
| G-rich loop rotation: | 49.7° |
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I4
H-bond protein
I10
H-bond protein
I11
H-bond protein
Binding pocket sequence
| Uniprot | KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVPGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA |
| Structure: | KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVPGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA |
Modified residues
Residue 197 (not in pocket)
Phosphorylated threonine
Residue 338 (not in pocket)
Phosphorylated serine