3NX8 - chain A (model B) | Protein kinase cAMP-activated catalytic subunit alpha
Structure information
| PDB: | 3NX8 |
| PubMed: | 22213702 |
| Release date: | 2011-07-13 |
| Resolution: | 2 Å |
| Kinase: | PRKACA (PKACa) |
| Family: | PKA |
| Group: | AGC |
| Species: | HUMAN |
| Quality Score: | 9.2 |
| Missing Residues: | 0 |
| Missing Atoms: | 8 |
| DFG conformation: | in |
| αC-helix conformation: | in |
| Salt bridge KIII.17 and EαC.24: | Yes (3.1Å) |
| ASP rotation (xDFG.81) : | 346° |
| PHE rotation (xDFG.82) : | 12° |
| Activation loop position: | -4.1Å |
| αC-helix position: | 17.9Å |
| G-rich loop angle: | 47.5° |
| G-rich loop distance: | 14.3Å |
| G-rich loop rotation: | 77.9° |
Other models from this PDB:
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I1
H-bond protein
I5
H-bond protein
I10
H-bond protein
I11
H-bond protein
Binding pocket sequence
| Uniprot | KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVPGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA |
| Structure: | KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVPGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA |
Modified residues
Residue 197 (not in pocket)
Phosphorylated threonine
Residue 338 (not in pocket)
Phosphorylated serine