4AE6 - chain B (model B) | Protein kinase cAMP-activated catalytic subunit alpha
Structure information
PDB: | 4AE6 |
PubMed: | 22504716 |
Release date: | 2012-04-18 |
Resolution: | 2.1 Å |
Kinase: | PRKACA (PKACa) |
Family: | PKA |
Group: | AGC |
Species: | HUMAN |
Quality Score: | 8 |
Missing Residues: | 0 |
Missing Atoms: | 0 |
DFG conformation: | in |
αC-helix conformation: | in |
Salt bridge KIII.17 and EαC.24: | Yes (4.4Å) |
ASP rotation (xDFG.81) : | 6° |
PHE rotation (xDFG.82) : | 17° |
Activation loop position: | -4.9Å |
αC-helix position: | 17Å |
G-rich loop angle: | 65.4° |
G-rich loop distance: | 20.9Å |
G-rich loop rotation: | 83.6° |
Other models from this PDB:
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I10
No H-bonds
Binding pocket sequence
Uniprot | KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVPGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA |
Structure: | KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVPGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA |
Modified residues
Residue 197 (not in pocket)
Phosphorylated threonine
Residue 338 (not in pocket)
Phosphorylated serine