4AE6 - chain B (model B) | Protein kinase cAMP-activated catalytic subunit alpha
Structure information
PDB:4AE6
PubMed:22504716
Release date:2012-04-18
Resolution:2.1 Å
 
Kinase:PRKACA (PKACa)
Family:PKA
Group:AGC
Species:HUMAN
 
Quality Score:8
Missing Residues:0
Missing Atoms:0
DFG conformation:in
αC-helix conformation:in
Salt bridge KIII.17 and EαC.24:Yes (4.4Å)
 
 
ASP rotation (xDFG.81) :
PHE rotation (xDFG.82) :17°
Activation loop position:-4.9Å
αC-helix position:17Å
 
G-rich loop angle:65.4°
G-rich loop distance:20.9Å
G-rich loop rotation:83.6°
Other models from this PDB:
2D & 3D views

The orthosteric binding pocket
Binding pocket waters
The following waters were found in the defined clusters:
I10
No H-bonds
Binding pocket sequence
UniprotKTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVPGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA
Structure:KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVPGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA


Modified residues
Residue 197 (not in pocket)
Phosphorylated threonine
Residue 338 (not in pocket)
Phosphorylated serine