2XB7 - chain A | Anaplastic lymphoma receptor tyrosine kinase
Structure information
| PDB: | 2XB7 |
| PubMed: | 20695522 |
| Release date: | 2010-07-28 |
| Resolution: | 2.5 Å |
| Kinase: | ALK |
| Family: | ALK |
| Group: | TK |
| Species: | HUMAN |
| Quality Score: | 8 |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| DFG conformation: | in |
| αC-helix conformation: | in |
| Salt bridge KIII.17 and EαC.24: | Yes (3.2Å) |
| ASP rotation (xDFG.81) : | 7° |
| PHE rotation (xDFG.82) : | 15° |
| Activation loop position: | -4.4Å |
| αC-helix position: | 17.2Å |
| G-rich loop angle: | 60.2° |
| G-rich loop distance: | 17.6Å |
| G-rich loop rotation: | 95.5° |
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I2
H-bond protein
I5
H-bond protein
Binding pocket sequence
| Uniprot | RGLGHGAFGEVYEVAVKTLDFLMEALIISKFNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA |
| Structure: | RGLGHGAFGEVYEVAVKTLDFLMEALIISKFNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA |
Modified residues
No modified residues identified.
Orthosteric ligand
Ligand HET-code: GUI
Ligand Name: 5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE
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- LABELS
- KLIFS residue #
- Amino Acid
- None
- COLORS
- Interaction types
- KLIFS (all res.)
- KLIFS (interacting res.)
- None
- OTHER
- Show/hide non-interacting res.
- En/disable resizing interacting res.
This ligand targets the following (sub)pockets:
| Main pockets | |
|---|---|
| Front | |
| Gate | |
| Back | |
| Subpockets | |
|---|---|
| FP-I | |
| FP-II | |
| BP-I-A | |
| BP-I-B | |
| BP-II-in | |
| BP-II-A-in | |
| BP-II-B-in | |
| BP-II-out | |
| BP-II-B | |
| BP-III | |
| BP-IV | |
| BP-V | |
Kinase-ligand interactions
■ Hydrophobic ♦ Aromatic face-to-face ♦ Aromatic face-to-edge ▲ H-bond donor ▲ H-bond acceptor ● Ionic positive ● Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 R 1120 | 2 G 1121 | 3 L 1122 | 4 G 1123 | 5 H 1124 | 6 G 1125 | 7 A 1126 | 8 F 1127 | 9 G 1128 | 10 E 1129 | 11 V 1130 | 12 Y 1131 | 13 E 1132 | 14 V 1147 | 15 A 1148 | 16 V 1149 | 17 K 1150 | 18 T 1151 | 19 L 1152 | 20 D 1163 |
| ■ | ■ | ■ | ■ | ■ | ■ | ■▲ | |||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 F 1164 | 22 L 1165 | 23 M 1166 | 24 E 1167 | 25 A 1168 | 26 L 1169 | 27 I 1170 | 28 I 1171 | 29 S 1172 | 30 K 1173 | 31 F 1174 | 32 N 1175 | 33 Q 1177 | 34 N 1178 | 35 I 1179 | 36 V 1180 | 37 R 1181 | 38 C 1182 | 39 I 1183 | 40 G 1184 |
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 V 1185 | 42 F 1193 | 43 I 1194 | 44 L 1195 | 45 L 1196 | 46 E 1197 | 47 L 1198 | 48 M 1199 | 49 A 1200 | 50 G 1201 | 51 G 1202 | 52 D 1203 | 53 L 1204 | 54 K 1205 | 55 S 1206 | 56 F 1207 | 57 L 1208 | 58 R 1209 | 59 E 1210 | 60 Y 1239 |
| ■ | ■ | ■ | ■▲▲ | ■ | ■ | ■ | ■▲ | ||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 1240 | 62 E 1241 | 63 E 1242 | 64 N 1243 | 65 H 1244 | 66 F 1245 | 67 I 1246 | 68 H 1247 | 69 R 1248 | 70 D 1249 | 71 I 1250 | 72 A 1251 | 73 A 1252 | 74 R 1253 | 75 N 1254 | 76 C 1255 | 77 L 1256 | 78 L 1257 | 79 I 1268 | 80 G 1269 |
| ■ | |||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 1270 | 82 F 1271 | 83 G 1272 | 84 M 1273 | 85 A 1274 | |||||||||||||||
| ■ | |||||||||||||||||||
Binding affinities
ChEMBL ID:CHEMBL509032Bioaffinities: 522 records for 299 kinase(s)
| Species | Kinase (ChEMBL naming) | Median | Min | Max | Type | Records |
|---|---|---|---|---|---|---|
| Homo sapiens | 3-phosphoinositide dependent protein kinase-1 | 6.6 | 6.6 | 6.6 | pKi | 1 |
| Homo sapiens | Activin receptor type-1 | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Activin receptor type-1 | 8 | 8 | 8 | pKi | 1 |
| Homo sapiens | Activin receptor type-1B | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Activin receptor type-2A | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Activin receptor type-2B | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Adaptor-associated kinase | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | ALK tyrosine kinase receptor | 8.5 | 8.5 | 8.5 | pEC50 | 1 |
| Homo sapiens | ALK tyrosine kinase receptor | 8.4 | 7.3 | 9.8 | pIC50 | 6 |
| Homo sapiens | ALK tyrosine kinase receptor | 9 | 9 | 9 | pKd | 1 |
| Homo sapiens | AMP-activated protein kinase, alpha-1 subunit | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | AMP-activated protein kinase, alpha-1 subunit | 8 | 8 | 8 | pKi | 1 |
| Homo sapiens | AMP-activated protein kinase, alpha-2 subunit | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Ankyrin repeat and protein kinase domain-containing protein 1 | 5 | 5 | 5 | pKd | 1 |
| Homo sapiens | BMP-2-inducible protein kinase | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Bone morphogenetic protein receptor type-1A | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Bone morphogenetic protein receptor type-1B | 9.1 | 9.1 | 9.1 | pKd | 1 |
| Homo sapiens | Bone morphogenetic protein receptor type-2 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | BR serine/threonine-protein kinase 1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | BR serine/threonine-protein kinase 1 | 7.3 | 7.3 | 7.3 | pKi | 1 |
| Homo sapiens | BR serine/threonine-protein kinase 2 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Plasmodium falciparum | Calcium-dependent protein kinase 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | CaM kinase I alpha | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | CaM kinase I delta | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | CaM kinase I delta | 6.4 | 6.4 | 6.4 | pKi | 1 |
| Homo sapiens | CaM kinase I gamma | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | CaM kinase II alpha | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | CaM kinase II alpha | 6.2 | 6.2 | 6.2 | pKi | 1 |
| Homo sapiens | CaM kinase II beta | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | CaM kinase II beta | 6.1 | 6.1 | 6.1 | pKi | 1 |
| Homo sapiens | CaM kinase II delta | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | CaM kinase II delta | 8.4 | 8.4 | 8.4 | pKi | 1 |
| Homo sapiens | CaM kinase II gamma | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | CaM kinase II gamma | 7.9 | 7.9 | 7.9 | pKi | 1 |
| Homo sapiens | CaM kinase IV | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | CaM-kinase kinase alpha | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | CaM-kinase kinase beta | 8 | 8 | 8 | pKd | 1 |
| Homo sapiens | cAMP-dependent protein kinase alpha-catalytic subunit | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | cAMP-dependent protein kinase alpha-catalytic subunit | 6.6 | 6.6 | 6.6 | pKi | 1 |
| Homo sapiens | cAMP-dependent protein kinase beta-1 catalytic subunit | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Casein kinase II alpha (prime) | 5 | 5 | 5 | pKd | 1 |
| Homo sapiens | Casein kinase I isoform alpha-like | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | cGMP-dependent protein kinase 1 beta | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | cGMP-dependent protein kinase 1 beta | 5.8 | 5.8 | 5.8 | pKi | 1 |
| Homo sapiens | cGMP-dependent protein kinase 2 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Chaperone activity of bc1 complex-like, mitochondrial | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | c-Jun N-terminal kinase 1 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | c-Jun N-terminal kinase 1 | 6.7 | 6.7 | 6.7 | pKi | 1 |
| Homo sapiens | c-Jun N-terminal kinase 2 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | c-Jun N-terminal kinase 2 | 6.4 | 6.4 | 6.4 | pKi | 1 |
| Homo sapiens | c-Jun N-terminal kinase 3 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 1 | 6.5 | 6.5 | 6.5 | pKi | 1 |
| Homo sapiens | Cyclin-dependent kinase 2 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 2 | 6.9 | 6.9 | 6.9 | pKi | 1 |
| Homo sapiens | Cyclin-dependent kinase 4 | 5.9 | 5.9 | 6.4 | pKd | 2 |
| Homo sapiens | Cyclin-dependent kinase 5 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 5 | 7.1 | 7.1 | 7.1 | pKi | 1 |
| Homo sapiens | Cyclin-dependent kinase 7 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 7 | 7.1 | 7.1 | 7.1 | pKi | 1 |
| Homo sapiens | Death-associated protein kinase 1 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Death-associated protein kinase 2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Death-associated protein kinase 3 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Death-associated protein kinase 3 | 6.4 | 6.4 | 6.4 | pKi | 1 |
| Homo sapiens | Discoidin domain-containing receptor 2 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Dual serine/threonine and tyrosine protein kinase | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | 6.1 | 6.1 | 6.1 | pKi | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 2 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 2 | 6.3 | 6.3 | 6.3 | pKi | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 3 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 4 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 5 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 6 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK2 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK2 | 7.6 | 7.6 | 7.6 | pKi | 1 |
| Homo sapiens | Dual specificity protein kinase CLK3 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK4 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK4 | 7.7 | 7.7 | 7.7 | pKi | 1 |
| Homo sapiens | Dual specificity protein kinase TTK | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | 5.8 | 5.8 | 5.8 | pKi | 1 |
| Homo sapiens | Dual specificty protein kinase CLK1 | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 1 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 3 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 4 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 5 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 6 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 7 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 2 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 3 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 4 | 5.9 | 5.9 | 5.9 | pIC50 | 1 |
| Homo sapiens | Ephrin type-B receptor 4 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 6 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Epidermal growth factor receptor erbB1 | 7 | 5.7 | 8.5 | pKd | 12 |
| Homo sapiens | Epidermal growth factor receptor erbB1 | 8 | 8 | 8 | pKi | 1 |
| Homo sapiens | Epithelial discoidin domain-containing receptor 1 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Eukaryotic translation initiation factor 2-alpha kinase 4 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 1 | 5.9 | 5.9 | 7.7 | pIC50 | 2 |
| Homo sapiens | Fibroblast growth factor receptor 1 | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 1 | 7.6 | 7.6 | 7.6 | pKi | 1 |
| Homo sapiens | Fibroblast growth factor receptor 2 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 3 | 7.1 | 7.1 | 7.1 | pIC50 | 1 |
| Homo sapiens | Fibroblast growth factor receptor 3 | 6.9 | 6.9 | 7 | pKd | 2 |
| Homo sapiens | Fibroblast growth factor receptor 3 | 7.4 | 7.4 | 7.4 | pKi | 1 |
| Homo sapiens | Fibroblast growth factor receptor 4 | 7.7 | 5.7 | 7.8 | pIC50 | 3 |
| Homo sapiens | Fibroblast growth factor receptor 4 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Focal adhesion kinase 1 | 9 | 9 | 9 | pKd | 1 |
| Homo sapiens | G protein-coupled receptor kinase 4 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | G protein-coupled receptor kinase 5 | 6.5 | 6.5 | 6.5 | pKi | 1 |
| Homo sapiens | G protein-coupled receptor kinase 7 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Hepatocyte growth factor receptor | 5.8 | 5.8 | 5.8 | pIC50 | 1 |
| Homo sapiens | Hepatocyte growth factor receptor | 6.8 | 6.8 | 7.2 | pKd | 3 |
| Homo sapiens | Hepatocyte growth factor receptor | 6.6 | 6.6 | 6.6 | pKi | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 1 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 2 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 3 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 4 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Hormonally up-regulated neu tumor-associated kinase | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Inhibitor of nuclear factor kappa B kinase epsilon subunit | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Inhibitor of nuclear factor kappa B kinase epsilon subunit | 6 | 6 | 6 | pKi | 1 |
| Homo sapiens | Insulin-like growth factor I receptor | 9.5 | 9.5 | 9.5 | pIC50 | 1 |
| Homo sapiens | Insulin-like growth factor I receptor | 8.6 | 8.6 | 8.6 | pKd | 1 |
| Homo sapiens | Insulin receptor | 6 | 6 | 6 | pEC50 | 1 |
| Homo sapiens | Insulin receptor | 7.4 | 5 | 8.7 | pIC50 | 4 |
| Homo sapiens | Insulin receptor | 8.6 | 8.6 | 8.6 | pKd | 1 |
| Homo sapiens | Insulin receptor | 6.3 | 6.3 | 6.3 | pKi | 1 |
| Rattus norvegicus | Insulin receptor | 5.9 | 5.9 | 5.9 | pIC50 | 1 |
| Homo sapiens | Insulin receptor-related protein | 8.2 | 8.2 | 8.2 | pKd | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 1 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 1 | 7.1 | 7.1 | 7.1 | pKi | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 3 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 4 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 4 | 7.4 | 7.4 | 7.4 | pKi | 1 |
| Homo sapiens | Leucine-rich repeat serine/threonine-protein kinase 2 | 7.7 | 7 | 8.2 | pIC50 | 4 |
| Homo sapiens | Leucine-rich repeat serine/threonine-protein kinase 2 | 8.9 | 8.9 | 9.1 | pKd | 2 |
| Homo sapiens | Leukocyte tyrosine kinase receptor | 9 | 9 | 9 | pKd | 1 |
| Homo sapiens | LIM domain kinase 1 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | LIM domain kinase 1 | 6.6 | 6.6 | 6.6 | pKi | 1 |
| Homo sapiens | LIM domain kinase 2 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Macrophage colony stimulating factor receptor | 7.3 | 7.3 | 7.3 | pIC50 | 1 |
| Homo sapiens | Macrophage colony stimulating factor receptor | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Macrophage colony stimulating factor receptor | 6.4 | 6.4 | 6.4 | pKi | 1 |
| Homo sapiens | Macrophage-stimulating protein receptor | 5.8 | 5.8 | 5.8 | pIC50 | 1 |
| Homo sapiens | Macrophage-stimulating protein receptor | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Macrophage-stimulating protein receptor | 6.9 | 6.9 | 6.9 | pKi | 1 |
| Homo sapiens | MAP kinase ERK1 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | MAP kinase ERK2 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | MAP kinase ERK2 | 6.7 | 6.7 | 6.7 | pKi | 1 |
| Homo sapiens | MAP kinase p38 gamma | 5 | 5 | 5 | pKd | 1 |
| Homo sapiens | MAP kinase signal-integrating kinase 2 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | MAP kinase signal-integrating kinase 2 | 6 | 6 | 6 | pKi | 1 |
| Homo sapiens | MAP/microtubule affinity-regulating kinase 2 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | MAP/microtubule affinity-regulating kinase 4 | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Maternal embryonic leucine zipper kinase | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Maternal embryonic leucine zipper kinase | 6.8 | 6.8 | 6.8 | pKi | 1 |
| Homo sapiens | Microtubule-associated serine/threonine-protein kinase 1 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Misshapen-like kinase 1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Misshapen-like kinase 1 | 6 | 6 | 6 | pKi | 1 |
| Homo sapiens | Mitogen-activated protein kinase 15 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase 7 | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 1 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 10 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 11 | 6.4 | 6.4 | 6.4 | pKd | 2 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 12 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 13 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 15 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 2 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 3 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 4 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 6 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 7 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 9 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 1 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 2 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 2 | 6.4 | 6.4 | 6.4 | pKi | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 3 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 4 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 4 | 6.5 | 6.5 | 6.5 | pKi | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 5 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 5 | 7.1 | 7.1 | 7.1 | pKi | 1 |
| Homo sapiens | Muscle, skeletal receptor tyrosine protein kinase | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Myosin IIIA | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Myosin-IIIB | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Myosin light chain kinase, smooth muscle | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Myotonin-protein kinase | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Nerve growth factor receptor Trk-A | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Neurotrophic tyrosine kinase receptor type 2 | 5.7 | 5.7 | 5.7 | pIC50 | 1 |
| Homo sapiens | Neurotrophic tyrosine kinase receptor type 2 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Non-receptor tyrosine-protein kinase TNK1 | 8.7 | 8.7 | 8.7 | pKd | 1 |
| Homo sapiens | NUAK family SNF1-like kinase 1 | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | NUAK family SNF1-like kinase 2 | 8.9 | 8.9 | 8.9 | pKd | 1 |
| Homo sapiens | Peripheral plasma membrane protein CASK | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha | 5 | 5 | 5 | pKd | 1 |
| Homo sapiens | Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Phosphorylase kinase gamma subunit 1 | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Phosphorylase kinase gamma subunit 2 | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Phosphorylase kinase gamma subunit 2 | 8.1 | 8.1 | 8.1 | pKi | 1 |
| Homo sapiens | PI4-kinase beta subunit | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor alpha | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor alpha | 6.5 | 6.5 | 6.5 | pKi | 1 |
| Homo sapiens | Platelet-derived growth factor receptor beta | 5.5 | 5.5 | 5.5 | pIC50 | 1 |
| Homo sapiens | Platelet-derived growth factor receptor beta | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor beta | 6.5 | 6.5 | 6.5 | pKi | 1 |
| Homo sapiens | Protein kinase C delta | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Protein kinase C delta | 6.5 | 6.5 | 6.5 | pKi | 1 |
| Homo sapiens | Protein kinase C epsilon | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Protein kinase C mu | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Protein kinase C nu | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Protein kinase C nu | 7.5 | 7.5 | 7.5 | pKi | 1 |
| Homo sapiens | Protein kinase C theta | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Protein kinase C theta | 6.1 | 6.1 | 6.1 | pKi | 1 |
| Homo sapiens | Protein kinase N1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Protein kinase N2 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Protein kinase N2 | 7 | 7 | 7 | pKi | 1 |
| Homo sapiens | Protein tyrosine kinase 2 beta | 9 | 9 | 9 | pKd | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase MER | 7.7 | 7.7 | 7.7 | pKd | 2 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase ROS | 8.7 | 8.7 | 8.7 | pIC50 | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase ROS | 9.3 | 9.3 | 9.3 | pKd | 1 |
| Homo sapiens | Putative uncharacterized serine/threonine-protein kinase SgK110 | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Receptor-interacting serine/threonine-protein kinase 4 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Receptor protein-tyrosine kinase erbB-2 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Receptor protein-tyrosine kinase erbB-2 | 7.4 | 7.4 | 7.4 | pKi | 1 |
| Homo sapiens | Receptor protein-tyrosine kinase erbB-4 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Receptor protein-tyrosine kinase erbB-4 | 7.7 | 7.7 | 7.7 | pKi | 1 |
| Homo sapiens | Rho-associated protein kinase 1 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Rho-associated protein kinase 1 | 7.2 | 7.2 | 7.2 | pKi | 1 |
| Homo sapiens | Rho-associated protein kinase 2 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Rho-associated protein kinase 2 | 6.8 | 6.8 | 6.8 | pKi | 1 |
| Homo sapiens | Rhodopsin kinase | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Ribosomal protein S6 kinase 1 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Ribosomal protein S6 kinase 1 | 6 | 6 | 6 | pKi | 1 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 1 | 6.2 | 6.2 | 6.8 | pKd | 4 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 2 | 6.8 | 6.8 | 7.5 | pKd | 4 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 3 | 7.8 | 7.8 | 7.8 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 3 | 8 | 8 | 8 | pKi | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 4 | 5.6 | 5.6 | 5.6 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 6 | 6.8 | 6.8 | 7.6 | pKd | 4 |
| Homo sapiens | Serine/threonine-protein kinase 10 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 16 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 17A | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 17A | 5.5 | 5.5 | 5.5 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase 17B | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 2 | 7.7 | 7.7 | 7.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 2 | 8.3 | 8.3 | 8.3 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase 24 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 25 | 5.1 | 5.1 | 5.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 32A | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 32B | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 32C | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 33 | 8.5 | 8.5 | 8.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 35 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 36 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 38 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 38-like | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-A | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-A | 7.9 | 7.9 | 7.9 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-B | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-B | 6.8 | 6.8 | 6.8 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-C | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Chk1 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Chk1 | 7 | 7 | 7 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase Chk2 | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Chk2 | 8.9 | 8.9 | 8.9 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase c-TAK1 | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase c-TAK1 | 7.8 | 7.8 | 7.8 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase D2 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase D2 | 7.3 | 7.3 | 7.3 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase DCLK1 | 8.3 | 8.3 | 8.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase DCLK1 | 7.4 | 7.4 | 7.4 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase DCLK2 | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase DCLK3 | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase/endoribonuclease IRE1 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase GAK | 8.3 | 8.3 | 8.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase ICK | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase LATS1 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase LATS2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MARK1 | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MRCK-A | 5.4 | 5.4 | 5.4 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase MRCK beta | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MRCK gamma | 5 | 5 | 5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST2 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST2 | 6.9 | 6.9 | 6.9 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST4 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase NEK2 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase NEK2 | 6.1 | 6.1 | 6.1 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase Nek3 | 5.1 | 5.1 | 5.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Nek4 | 6.2 | 6.2 | 6.2 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase NEK6 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase NEK7 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase NEK9 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase NIM1 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase OSR1 | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 1 | 5.4 | 5.4 | 5.4 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 2 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 3 | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 4 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 4 | 6.4 | 6.4 | 6.4 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK6 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK7 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-1 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PFTAIRE-2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Mycobacterium tuberculosis | Serine/threonine-protein kinase pknB | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK1 | 7.7 | 7.7 | 7.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK1 | 6.7 | 6.7 | 6.7 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK3 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK3 | 5.5 | 5.5 | 5.5 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK4 | 9 | 9 | 9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK4 | 8.5 | 8.5 | 8.5 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase PRKX | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PRP4 homolog | 5.1 | 5.1 | 5.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase receptor R3 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RIO3 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RIPK2 | 5 | 5 | 5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SBK1 | 7.7 | 7.7 | 7.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK1 | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK2 | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK3 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SRPK1 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SRPK1 | 6 | 6 | 6 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase SRPK3 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TAO1 | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TAO1 | 6.8 | 6.8 | 6.8 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase TAO2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TAO3 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TBK1 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TBK1 | 6.2 | 6.2 | 6.2 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase TNNI3K | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase ULK1 | 9.1 | 9.1 | 9.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase ULK2 | 8.7 | 8.7 | 8.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase ULK3 | 8 | 8 | 8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase WEE1 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | SNF-related serine/threonine-protein kinase | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | SPS1/STE20-related protein kinase YSK4 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | STE20/SPS1-related proline-alanine-rich protein kinase | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Stem cell growth factor receptor | 6.9 | 5.9 | 7.6 | pKd | 8 |
| Homo sapiens | Testis-specific serine/threonine-protein kinase 1 | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Testis-specific serine/threonine-protein kinase 1 | 7.5 | 7.5 | 7.5 | pKi | 1 |
| Homo sapiens | Testis-specific serine/threonine-protein kinase 2 | 8 | 8 | 8 | pKi | 1 |
| Homo sapiens | TGF-beta receptor type I | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | TGF-beta receptor type II | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | TRAF2- and NCK-interacting kinase | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Tyrosine kinase non-receptor protein 2 | 8.7 | 8.7 | 8.7 | pKd | 1 |
| Homo sapiens | Tyrosine kinase non-receptor protein 2 | 9.1 | 9.1 | 9.1 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase ABL | 6 | 6 | 6 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase ABL | 7.1 | 6.7 | 8.3 | pKd | 15 |
| Homo sapiens | Tyrosine-protein kinase ABL | 6.6 | 6.6 | 6.6 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase ABL2 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BLK | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BLK | 7.2 | 7.2 | 7.2 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase BMX | 5.8 | 5.8 | 5.8 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase BMX | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BRK | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BRK | 7.9 | 7.9 | 7.9 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase BTK | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BTK | 7.3 | 7.3 | 7.3 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase CSK | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase CTK | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FER | 8.9 | 8.9 | 8.9 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FES | 6.3 | 6.3 | 6.3 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase FES | 8.3 | 8.3 | 8.3 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FGR | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FRK | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FRK | 8.6 | 8.6 | 8.6 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase FYN | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FYN | 6.3 | 6.3 | 6.3 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase HCK | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase ITK/TSK | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase ITK/TSK | 8.3 | 8.3 | 8.3 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase JAK1 | 6.4 | 6.4 | 6.5 | pKd | 4 |
| Homo sapiens | Tyrosine-protein kinase JAK2 | 5.8 | 5.8 | 5.8 | pIC50 | 2 |
| Homo sapiens | Tyrosine-protein kinase JAK2 | 7.8 | 7.8 | 7.8 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase JAK2 | 6.8 | 6.8 | 6.8 | pKi | 2 |
| Homo sapiens | Tyrosine-protein kinase JAK3 | 7.8 | 7.8 | 7.8 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase JAK3 | 6.7 | 6.7 | 6.7 | pKi | 2 |
| Homo sapiens | Tyrosine-protein kinase LCK | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase LCK | 6.9 | 6.9 | 6.9 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase Lyn | 5.9 | 5.9 | 5.9 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase Lyn | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase Lyn | 7.1 | 7.1 | 7.1 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 6.3 | 6.3 | 6.3 | pEC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 6.3 | 5.5 | 8.5 | pIC50 | 6 |
| Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 8 | 7.5 | 8.7 | pKd | 8 |
| Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 7.4 | 7.4 | 7.4 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor RET | 5.9 | 5.9 | 5.9 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor RET | 6.9 | 6.8 | 6.9 | pKd | 4 |
| Homo sapiens | Tyrosine-protein kinase receptor RET | 7.4 | 7.4 | 7.4 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor Tie-1 | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor TYRO3 | 5.1 | 5.1 | 5.1 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase receptor UFO | 7.9 | 7.9 | 7.9 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase receptor UFO | 8 | 8 | 8 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase SRC | 5.9 | 5.9 | 5.9 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase SRC | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase SRC | 7.6 | 7.6 | 7.6 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase Srms | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase Srms | 6.5 | 6.5 | 6.5 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase SYK | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase SYK | 7.1 | 7.1 | 7.1 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase TEC | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TIE-2 | 5.9 | 5.9 | 5.9 | pEC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase TIE-2 | 5.9 | 4.9 | 7.9 | pIC50 | 3 |
| Homo sapiens | Tyrosine-protein kinase TIE-2 | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TXK | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TYK2 | 5.6 | 5.6 | 5.6 | pIC50 | 2 |
| Homo sapiens | Tyrosine-protein kinase TYK2 | 5.7 | 5.7 | 7.1 | pKd | 4 |
| Homo sapiens | Tyrosine-protein kinase TYK2 | 6.7 | 6.7 | 6.7 | pKi | 2 |
| Homo sapiens | Tyrosine-protein kinase YES | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase ZAP-70 | 5.8 | 5.8 | 5.8 | pIC50 | 1 |
| Homo sapiens | Tyrosine-protein kinase ZAP-70 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Uncharacterized aarF domain-containing protein kinase 4 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | 6.1 | 6.1 | 6.1 | pEC50 | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | 6.1 | 6.1 | 6.1 | pIC50 | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | 7.1 | 7.1 | 7.1 | pKi | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 5.7 | 5.7 | 5.7 | pIC50 | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 6.9 | 6.9 | 6.9 | pKi | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 3 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 3 | 8.1 | 8.1 | 8.1 | pKi | 1 |