2YHV - chain A | Anaplastic lymphoma receptor tyrosine kinase
Structure information
PDB: | 2YHV |
PubMed: | 24432909 |
Release date: | 2011-05-18 |
Resolution: | 1.9 Å |
Kinase: | ALK |
Family: | ALK |
Group: | TK |
Species: | HUMAN |
Quality Score: | 6.8 |
Missing Residues: | 3 |
Missing Atoms: | 0 |
DFG conformation: | in |
αC-helix conformation: | in |
Salt bridge KIII.17 and EαC.24: | No (5Å) |
ASP rotation (xDFG.81) : | 4° |
PHE rotation (xDFG.82) : | 18° |
Activation loop position: | -4.3Å |
αC-helix position: | 17.4Å |
G-rich loop angle: | - |
G-rich loop distance: | - |
G-rich loop rotation: | - |
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I1
H-bond protein
I4
H-bond protein
I6
H-bond protein
Binding pocket sequence
Uniprot | RGLGHGAFGEVYEVAVKTLDFLMEALIISKFNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA |
Structure: | RGL___AFGEVYEVAVKTLDFLMEALIISKFNQNIVRCIGVFILMELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA |
Modified residues
No modified residues identified.