2YJR - chain A (model A) | Anaplastic lymphoma receptor tyrosine kinase
Structure information
PDB:2YJR
PubMed:-
Release date:2012-06-06
Resolution:1.9 Å
 
Kinase:ALK
Family:ALK
Group:TK
Species:HUMAN
 
Quality Score:7.6
Missing Residues:1
Missing Atoms:0
DFG conformation:in
αC-helix conformation:in
Salt bridge KIII.17 and EαC.24:Yes (3.1Å)
 
 
ASP rotation (xDFG.81) :329°
PHE rotation (xDFG.82) :
Activation loop position:-3.6Å
αC-helix position:18.6Å
 
G-rich loop angle:65.5°
G-rich loop distance:19Å
G-rich loop rotation:70.7°
Other models from this PDB:
2D & 3D views

The orthosteric binding pocket
Binding pocket waters
The following waters were found in the defined clusters:
I1
H-bond protein
I6
No H-bonds
Binding pocket sequence
UniprotRGLGHGAFGEVYEVAVKTLDFLMEALIISKFNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA
Structure:RGLGHGAFGEVYEVAVKTLDFLMEALIISKLNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGM_


Modified residues
No modified residues identified.