4FNW - chain A | Anaplastic lymphoma receptor tyrosine kinase
Structure information
PDB:4FNW
PubMed:22932897
Release date:2012-08-29
Resolution:1.75 Å
 
Kinase:ALK
Family:ALK
Group:TK
Species:HUMAN
 
Quality Score:6.4
Missing Residues:4
Missing Atoms:0
DFG conformation:in
αC-helix conformation:in
Salt bridge KIII.17 and EαC.24:Yes (3.3Å)
 
 
ASP rotation (xDFG.81) :
PHE rotation (xDFG.82) :16°
Activation loop position:-4.2Å
αC-helix position:17.3Å
 
G-rich loop angle:-
G-rich loop distance:-
G-rich loop rotation:-
2D & 3D views

The orthosteric binding pocket
Binding pocket waters
The following waters were found in the defined clusters:
I1
H-bond protein
I4
H-bond protein
I6
No H-bonds
I7
No H-bonds
I11
H-bond protein
Binding pocket sequence
UniprotRGLGHGAFGEVYEVAVKTLDFLMEALIISKFNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA
Structure:RGLG____GEVYEVAVKTLDFLMEALIISKLNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA


Modified residues
No modified residues identified.