4FNW - chain A | Anaplastic lymphoma receptor tyrosine kinase
Structure information
PDB: | 4FNW |
PubMed: | 22932897 |
Release date: | 2012-08-29 |
Resolution: | 1.75 Å |
Kinase: | ALK |
Family: | ALK |
Group: | TK |
Species: | HUMAN |
Quality Score: | 6.4 |
Missing Residues: | 4 |
Missing Atoms: | 0 |
DFG conformation: | in |
αC-helix conformation: | in |
Salt bridge KIII.17 and EαC.24: | Yes (3.3Å) |
ASP rotation (xDFG.81) : | 3° |
PHE rotation (xDFG.82) : | 16° |
Activation loop position: | -4.2Å |
αC-helix position: | 17.3Å |
G-rich loop angle: | - |
G-rich loop distance: | - |
G-rich loop rotation: | - |
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I1
H-bond protein
I4
H-bond protein
I6
No H-bonds
I7
No H-bonds
I11
H-bond protein
Binding pocket sequence
Uniprot | RGLGHGAFGEVYEVAVKTLDFLMEALIISKFNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA |
Structure: | RGLG____GEVYEVAVKTLDFLMEALIISKLNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA |
Modified residues
No modified residues identified.