4TT7 - chain A (model A) | Anaplastic lymphoma receptor tyrosine kinase
Structure information
| PDB: | 4TT7 |
| PubMed: | 25678804 |
| Release date: | 2015-02-11 |
| Resolution: | 2.1 Å |
| Kinase: | ALK |
| Family: | ALK |
| Group: | TK |
| Species: | HUMAN |
| Quality Score: | 6.4 |
| Missing Residues: | 4 |
| Missing Atoms: | 0 |
| DFG conformation: | in |
| αC-helix conformation: | in |
| Salt bridge KIII.17 and EαC.24: | Yes (2.9Å) |
| ASP rotation (xDFG.81) : | 5° |
| PHE rotation (xDFG.82) : | 20° |
| Activation loop position: | -4.3Å |
| αC-helix position: | 17.5Å |
| G-rich loop angle: | - |
| G-rich loop distance: | - |
| G-rich loop rotation: | - |
Other models from this PDB:
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I3
No H-bonds
I4
H-bond protein
I6
No H-bonds
Binding pocket sequence
| Uniprot | RGLGHGAFGEVYEVAVKTLDFLMEALIISKFNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA |
| Structure: | RGLG____GEVYEVAVKTLDFLMEALIISKFNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA |
Modified residues
No modified residues identified.
Allosteric ligand
Ligand HET-code: COM
Ligand Name: 1-THIOETHANESULFONIC ACID
Binding affinities
Ligand not found in ChEMBL.