4OTD - chain A (model A) | Protein kinase N1
Structure information
| PDB: | 4OTD |
| PubMed: | 25111382 |
| Release date: | 2014-08-27 |
| Resolution: | 2 Å |
| Kinase: | PKN1 |
| Family: | PKN |
| Group: | AGC |
| Species: | HUMAN |
| Quality Score: | 8.9 |
| Missing Residues: | 0 |
| Missing Atoms: | 11 |
| DFG conformation: | in |
| αC-helix conformation: | in |
| Salt bridge KIII.17 and EαC.24: | Yes (2.6Å) |
| ASP rotation (xDFG.81) : | 13° |
| PHE rotation (xDFG.82) : | 8° |
| Activation loop position: | -4.7Å |
| αC-helix position: | 19.2Å |
| G-rich loop angle: | 54.9° |
| G-rich loop distance: | 16.8Å |
| G-rich loop rotation: | 39.2° |
Other models from this PDB:
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I1
H-bond protein
I3
No H-bonds
I4
H-bond protein
I6
No H-bonds
I8
No H-bonds
Binding pocket sequence
| Uniprot | AVLGRGHFGKVLLFAIKALSLMCEKRILAAVTPFLVNLFGCCFVMEYSAGGDLMLHIHSFLHEHKIVYRDLKLDNLLLIADFGLC |
| Structure: | AVLGRGHFGKVLLFAIKALSLMCEKRILAAVTPFLVNLFGCCFVMEYSAGGDLMLHIHSFLHEHKIVYRDLKLDNLLLIADFGLC |
Modified residues
Residue 780 (not in pocket)
Phosphorylated threonine
Residue 922 (not in pocket)
Phosphorylated serine