4NIF - chain A (model A) | Ribosomal protein S6 kinase A1 (2nd domain)
Structure information
| PDB: | 4NIF |
| PubMed: | 25730857 |
| Release date: | 2014-11-12 |
| Resolution: | 2.15 Å |
| Kinase: | RPS6KA1-b (RSK3-b) |
| Family: | RSKb |
| Group: | CAMK |
| Species: | HUMAN |
| Quality Score: | 8 |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| DFG conformation: | in |
| αC-helix conformation: | in |
| Salt bridge KIII.17 and EαC.24: | Yes (2.6Å) |
| ASP rotation (xDFG.81) : | 342° |
| PHE rotation (xDFG.82) : | 9° |
| Activation loop position: | -3.6Å |
| αC-helix position: | 18Å |
| G-rich loop angle: | 52.5° |
| G-rich loop distance: | 15.6Å |
| G-rich loop rotation: | 62.2° |
Other models from this PDB:
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I3
H-bond protein
I4
H-bond protein
I5
H-bond protein
Binding pocket sequence
| Uniprot | ETIGVGSYSECKRYAVKVIDPSEEIEILLRYGPNIITLKDVYLVTELMRGGELLDKILRYLHSQGVVHRDLKPSNILYICDFGFA |
| Structure: | ETIGVGSYSECKRYAVKVIDPSEEIEILLRYGPNIITLKDVYLVTELMRGGELLDKILRYLHSQGVVHRDLKPSNILYICDFGFA |
Modified residues
No modified residues identified.