KLIFS - the structural kinase database

4QMZ - chain A | Serine/threonine kinase 24

Structure information


PDB:	4QMZ
PubMed:	27135311
Release date:	2015-07-01
Resolution:	1.88 Å

Kinase:	STK24 (MST3)
Family:	STE20
Group:	STE
Species:	HUMAN

Quality Score:	8
Missing Residues:	0
Missing Atoms:	0

DFG conformation:	in
αC-helix conformation:	in
Salt bridge K^III.17 and E^αC.24:	Yes (2.8Å)


ASP rotation (xDFG.81) :	346°
PHE rotation (xDFG.82) :	15°
Activation loop position:	-3.2Å
αC-helix position:	17.7Å

G-rich loop angle:	61°
G-rich loop distance:	17.6Å
G-rich loop rotation:	64°

2D & 3D views

Binding pocket waters

The following waters were found in the defined clusters:

H-bond ligand

H-bond protein

I10

H-bond protein

Binding pocket sequence

Uniprot	EKIGKGSFGEVFKVAIKIIDIQQEITVLSQCDPYVTKYYGSWIIMEYLGGGSALDLLEPYLHSEKKIHRDIKAANVLLLADFGVA
Structure:	EKIGKGSFGEVFKVAIKIIDIQQEITVLSQCDPYVTKYYGSWIIMEYLGGGSALDLLEPYLHSEKKIHRDIKAANVLLLADFGVA

Modified residues

Residue 178 (not in pocket)

Phosphorylated threonine

Orthosteric ligand

Ligand HET-code: B49
Ligand Name: N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide

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LABELS
KLIFS residue #
Amino Acid
None
COLORS
Interaction types
KLIFS (all res.)
KLIFS (interacting res.)
None
OTHER
Show/hide non-interacting res.
En/disable resizing interacting res.

This ligand targets the following (sub)pockets:

Main pockets
Front
Gate
Back

Subpockets
FP-I
FP-II
BP-I-A
BP-I-B
BP-II-in
BP-II-A-in
BP-II-B-in
BP-II-out
BP-II-B
BP-III
BP-IV
BP-V

Kinase-ligand interactions

■ Hydrophobic ♦ Aromatic face-to-face ♦ Aromatic face-to-edge ▲ H-bond donor ▲ H-bond acceptor ● Ionic positive ● Ionic negative

g.l

III

αC

1 E
28

2 K
29

3 I
30

4 G
31

5 K
32

6 G
33

7 S
34

8 F
35

9 G
36

10 E
37

11 V
38

12 F
39

13 K
40

14 V
50

15 A
51

16 I
52

17 K
53

18 I
54

19 I
55

20 D
66

■

αC

b.l

21 I
67

22 Q
68

23 Q
69

24 E
70

25 I
71

26 T
72

27 V
73

28 L
74

29 S
75

30 Q
76

31 C
77

32 D
78

33 P
80

34 Y
81

35 V
82

36 T
83

37 K
84

38 Y
85

39 Y
86

40 G
87

■

hinge

linker

αD

αE

41 S
88

42 W
96

43 I
97

44 I
98

45 M
99

46 E
100

47 Y
101

48 L
102

49 G
103

50 G
104

51 G
105

52 S
106

53 A
107

54 L
108

55 D
109

56 L
110

57 L
111

58 E
112

59 P
113

60 Y
134

■

▲

■

■▲▲

■

αE

c.l

VII

VIII

61 L
135

62 H
136

63 S
137

64 E
138

65 K
139

66 K
140

67 I
141

68 H
142

69 R
143

70 D
144

71 I
145

72 K
146

73 A
147

74 A
148

75 N
149

76 V
150

77 L
151

78 L
152

79 L
160

80 A
161

■

DFG

a.l

81 D
162

82 F
163

83 G
164

84 V
165

85 A
166

Interaction pattern search

Search KLIFS for kinase-ligand complexes with similar interaction patterns:

Binding affinities

ChEMBL ID:CHEMBL535
Bioaffinities: 1167 records for 270 kinase(s)

Species	Kinase (ChEMBL naming)	Median	Min	Max	Type	Records
Homo sapiens	3-phosphoinositide dependent protein kinase-1	5.5	5.5	5.5	pKd	3
Homo sapiens	Adaptor-associated kinase	7.3	7.3	7.3	pIC50	1
Homo sapiens	Adaptor-associated kinase	8	6.4	8	pKd	6
Homo sapiens	ALK tyrosine kinase receptor	5.6	5.6	7.3	pIC50	2
Homo sapiens	ALK tyrosine kinase receptor	6.8	6.8	6.8	pKd	3
Homo sapiens	AMP-activated protein kinase, alpha-1 subunit	7.3	6	7.7	pKd	6
Homo sapiens	AMP-activated protein kinase, alpha-2 subunit	7.1	7.1	7.1	pKd	3
Homo sapiens	AMP-activated protein kinase, gamma-1 subunit	5.9	5.9	5.9	pKd	1
Homo sapiens	AMP-activated protein kinase, gamma-2 subunit	5.8	5.8	5.8	pKd	1
Homo sapiens	Ankyrin repeat and protein kinase domain-containing protein 1	6.5	6.5	6.5	pKd	3
Homo sapiens	BMP-2-inducible protein kinase	7.4	7.1	8.3	pKd	6
Homo sapiens	Bone morphogenetic protein receptor type-1B	5.6	5.6	5.6	pKd	1
Homo sapiens	Bone morphogenetic protein receptor type-2	6.2	5.6	6.2	pKd	4
Homo sapiens	BR serine/threonine-protein kinase 1	5.5	5.5	5.5	pKd	3
Homo sapiens	BR serine/threonine-protein kinase 2	6	6	6	pKd	3
Plasmodium falciparum	Calcium-dependent protein kinase 1	5.9	5.9	5.9	pKd	1
Homo sapiens	CaM kinase I alpha	6	5.7	6	pKd	4
Homo sapiens	CaM kinase I delta	6.3	6	6.3	pKd	4
Homo sapiens	CaM kinase I gamma	6.4	6	6.4	pKd	3
Homo sapiens	CaM kinase II alpha	7.1	6.4	7.1	pKd	5
Homo sapiens	CaM kinase II beta	5.9	5.5	5.9	pKd	4
Homo sapiens	CaM kinase II delta	6.4	6	6.4	pKd	4
Homo sapiens	CaM kinase II gamma	6.2	6.1	6.4	pKd	7
Homo sapiens	CaM kinase IV	6.1	5.5	6.1	pKd	4
Homo sapiens	CaM-kinase kinase alpha	6.4	6.1	6.4	pKd	4
Homo sapiens	CaM-kinase kinase beta	5.8	5.2	5.8	pKd	4
Homo sapiens	Casein kinase I alpha	6.3	5.1	7	pKd	3
Homo sapiens	Casein kinase I delta	7.8	6.1	7.8	pKd	4
Homo sapiens	Casein kinase I epsilon	7.9	6.1	7.9	pKd	4
Homo sapiens	Casein kinase I gamma 1	6	5.5	6	pKd	4
Homo sapiens	Casein kinase I gamma 2	7	7	7	pKd	3
Homo sapiens	Casein kinase II alpha	7.1	6.1	7.1	pKd	3
Homo sapiens	Casein kinase II alpha (prime)	6.4	5.5	6.8	pKd	4
Homo sapiens	Casein kinase I isoform alpha-like	6.3	6.3	6.3	pKd	2
Homo sapiens	Casein kinase I isoform gamma-3	6.6	5.5	6.6	pKd	4
Homo sapiens	Citron Rho-interacting kinase	5.4	5.4	5.4	pKd	3
Homo sapiens	c-Jun N-terminal kinase 2	5.6	5.6	5.6	pKd	1
Homo sapiens	c-Jun N-terminal kinase 3	5.4	5.4	5.4	pKd	1
Homo sapiens	Cyclin-dependent kinase 3	6	6	6	pKd	1
Homo sapiens	Cyclin-dependent kinase 4	5.2	5.2	5.7	pKd	2
Homo sapiens	Cyclin-dependent kinase 5	5.2	5.2	5.2	pKd	1
Homo sapiens	Cyclin-dependent kinase 7	6.5	5.9	6.5	pKd	4
Homo sapiens	Cyclin-dependent kinase-like 2	6	6	6	pKd	2
Homo sapiens	Death-associated protein kinase 1	6.9	6.9	6.9	pKd	3
Homo sapiens	Death-associated protein kinase 2	6.8	6.3	6.8	pKd	5
Homo sapiens	Death-associated protein kinase 3	7	6.5	7.7	pKd	6
Homo sapiens	Discoidin domain-containing receptor 2	5.5	5.5	5.5	pKd	1
Homo sapiens	Dual serine/threonine and tyrosine protein kinase	5.9	5.9	5.9	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	6.9	5.6	6.9	pKd	4
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	7	5.8	7	pKd	4
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 3	5.8	5.8	5.8	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 4	6.2	6.2	6.2	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 5	5.5	5.5	7.3	pKd	2
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 6	5.3	5.3	5.3	pKd	1
Homo sapiens	Dual specificity protein kinase CLK2	7.7	6	7.7	pKd	7
Homo sapiens	Dual specificity protein kinase CLK4	7.5	7.1	7.5	pKd	6
Homo sapiens	Dual specificity protein kinase TTK	7.2	6.6	7.2	pKd	5
Homo sapiens	Dual-specificity tyrosine-phosphorylation regulated kinase 1A	6.7	5.4	6.7	pKd	3
Homo sapiens	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	5.6	5.6	5.6	pKd	3
Homo sapiens	Dual-specificity tyrosine-phosphorylation regulated kinase 2	6.2	6.2	6.2	pKd	2
Homo sapiens	Dual specificty protein kinase CLK1	7.7	6.4	7.7	pKd	7
Homo sapiens	Ephrin type-A receptor 3	5.7	5.7	5.7	pKd	3
Homo sapiens	Ephrin type-A receptor 5	5.2	5.2	5.9	pKd	2
Homo sapiens	Ephrin type-A receptor 6	6	5.7	6	pKd	4
Homo sapiens	Ephrin type-A receptor 7	5.6	5.6	6.2	pKd	5
Homo sapiens	Ephrin type-B receptor 1	6.3	6	6.3	pKd	5
Homo sapiens	Ephrin type-B receptor 4	5.5	5.5	5.7	pKd	2
Homo sapiens	Ephrin type-B receptor 6	6	6	6.1	pKd	2
Homo sapiens	Epidermal growth factor receptor erbB1	6.8	4.8	7.5	pIC50	6
Homo sapiens	Epidermal growth factor receptor erbB1	5.2	5.2	6.1	pKd	6
Homo sapiens	Epithelial discoidin domain-containing receptor 1	5.7	5.7	5.7	pKd	3
Homo sapiens	Eukaryotic translation initiation factor 2-alpha kinase 4	6.8	6.8	6.8	pKd	3
Homo sapiens	Fibroblast growth factor receptor 1	6	5.5	6.8	pIC50	3
Homo sapiens	Fibroblast growth factor receptor 1	6.3	5.4	6.3	pKd	5
Homo sapiens	Fibroblast growth factor receptor 2	6.2	6.2	6.3	pKd	5
Homo sapiens	Fibroblast growth factor receptor 3	6.5	5.9	6.5	pKd	7
Homo sapiens	Fibroblast growth factor receptor 4	5.7	5.7	5.7	pKd	1
Homo sapiens	Focal adhesion kinase 1	5.8	5.8	5.8	pIC50	1
Homo sapiens	Focal adhesion kinase 1	6.4	6.2	6.4	pKd	5
Homo sapiens	G protein-coupled receptor kinase 4	6.9	6.9	6.9	pKd	2
Homo sapiens	G protein-coupled receptor kinase 6	5.8	5.8	5.8	pKd	1
Homo sapiens	G protein-coupled receptor kinase 7	6.8	6.8	6.8	pKd	2
Homo sapiens	Hepatocyte growth factor receptor	5	5	5.7	pIC50	2
Homo sapiens	Hepatocyte growth factor receptor	5.3	5.1	5.9	pKd	5
Homo sapiens	Homeodomain-interacting protein kinase 1	7.3	7.3	7.3	pKd	1
Homo sapiens	Homeodomain-interacting protein kinase 2	7.5	7.5	7.5	pKd	2
Homo sapiens	Homeodomain-interacting protein kinase 3	7.4	7.4	7.4	pKd	2
Homo sapiens	Homeodomain-interacting protein kinase 4	6.8	6.8	6.8	pKd	2
Homo sapiens	Hormonally up-regulated neu tumor-associated kinase	6.3	6.3	6.3	pKd	2
Homo sapiens	Inhibitor of nuclear factor kappa B kinase alpha subunit	6.3	6.3	6.3	pKd	2
Homo sapiens	Inhibitor of nuclear factor kappa B kinase epsilon subunit	6.2	5.8	6.2	pKd	4
Homo sapiens	Insulin-like growth factor I receptor	5.6	5.6	5.6	pKd	3
Homo sapiens	Insulin receptor	5.5	5.5	5.5	pIC50	1
Homo sapiens	Insulin receptor	6.3	6.3	6.8	pKd	5
Homo sapiens	Insulin receptor-related protein	6.4	6.4	6.4	pKd	3
Homo sapiens	Interferon-induced, double-stranded RNA-activated protein kinase	6.2	6.2	6.2	pKd	3
Homo sapiens	Interleukin-1 receptor-associated kinase 1	7.9	7.9	7.9	pKd	2
Homo sapiens	Interleukin-1 receptor-associated kinase 3	6	6	6	pKd	3
Homo sapiens	Interleukin-1 receptor-associated kinase 4	5.6	5.6	7.2	pKd	2
Homo sapiens	Leucine-rich repeat serine/threonine-protein kinase 2	7.6	7.6	7.8	pIC50	2
Homo sapiens	Leucine-rich repeat serine/threonine-protein kinase 2	7	7	7.1	pKd	2
Homo sapiens	Leukocyte tyrosine kinase receptor	5.8	5.8	5.8	pKd	3
Homo sapiens	Macrophage colony stimulating factor receptor	6.8	6.8	7.5	pIC50	2
Homo sapiens	Macrophage colony stimulating factor receptor	8.7	8.6	8.7	pKd	3
Homo sapiens	MAP kinase-interacting serine/threonine-protein kinase MNK1	5.4	5.4	5.4	pKd	1
Homo sapiens	MAP kinase signal-integrating kinase 2	5.2	5.2	5.2	pKd	1
Homo sapiens	MAP/microtubule affinity-regulating kinase 2	6.5	5.5	6.5	pKd	5
Homo sapiens	MAP/microtubule affinity-regulating kinase 4	5.4	5.4	5.4	pKd	3
Homo sapiens	Maternal embryonic leucine zipper kinase	6.5	5.9	6.5	pKd	4
Homo sapiens	Microtubule-associated serine/threonine-protein kinase 1	6.7	6.7	6.7	pKd	2
Homo sapiens	Misshapen-like kinase 1	7.5	7.5	7.5	pKd	2
Homo sapiens	Mitogen-activated protein kinase 7	5	5	5	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 11	5.9	5.5	5.9	pKd	4
Homo sapiens	Mitogen-activated protein kinase kinase kinase 12	7	7	7	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 13	7	7	7	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 15	5.9	5.9	5.9	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 2	7.2	5.6	7.2	pKd	3
Homo sapiens	Mitogen-activated protein kinase kinase kinase 3	6.7	5.5	6.7	pKd	3
Homo sapiens	Mitogen-activated protein kinase kinase kinase 4	5.3	5.3	5.5	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 7	7	7	7	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 9	5.5	5.5	5.5	pKd	3
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 1	7.8	6.6	7.8	pKd	4
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	7.5	7.5	7.5	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 3	6.8	6.3	6.8	pKd	4
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 4	6.9	6.6	6.9	pKd	4
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	7.1	5.9	7.4	pKd	6
Homo sapiens	Mitotic checkpoint serine/threonine-protein kinase BUB1	5.5	5.5	5.5	pKd	1
Homo sapiens	Muscle, skeletal receptor tyrosine protein kinase	6.3	6.3	6.3	pKd	3
Homo sapiens	Myosin IIIA	5.5	5.5	5.5	pKd	1
Homo sapiens	Myosin-IIIB	5.4	5.4	5.4	pKd	3
Homo sapiens	Myosin light chain kinase	7.6	7.6	7.6	pKd	1
Homo sapiens	myosin light chain kinase 2	7.3	7.2	7.3	pKd	5
Homo sapiens	Myosin light chain kinase family member 4	7.8	7.8	7.8	pKd	3
Gallus gallus	Myosin light chain kinase, smooth muscle	7.6	7.6	7.6	pKd	1
Homo sapiens	Myosin light chain kinase, smooth muscle	6.6	6.6	7.6	pKd	4
Homo sapiens	Nerve growth factor receptor Trk-A	6.7	5.7	7	pKd	6
Homo sapiens	Neurotrophic tyrosine kinase receptor type 2	6.2	6.2	6.2	pKd	3
Homo sapiens	Non-receptor tyrosine-protein kinase TNK1	6.2	6.2	6.2	pKd	3
Homo sapiens	NT-3 growth factor receptor	5.3	5.3	5.3	pKd	3
Homo sapiens	NUAK family SNF1-like kinase 1	7.3	7.3	7.3	pKd	3
Homo sapiens	NUAK family SNF1-like kinase 2	6.8	6.8	6.8	pKd	3
Homo sapiens	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha	5.3	5.3	5.3	pKd	3
Homo sapiens	Phosphatidylinositol-5-phosphate 4-kinase type-2 beta	7.4	7.4	7.4	pKd	3
Homo sapiens	Phosphorylase kinase gamma subunit 1	8.3	7.2	8.3	pKd	5
Homo sapiens	Phosphorylase kinase gamma subunit 2	7.4	6.2	8.2	pKd	6
Homo sapiens	PI3-kinase p110-alpha subunit	5	5	5	pIC50	1
Homo sapiens	PI3-kinase p110-delta subunit	4.9	4.9	4.9	pIC50	1
Homo sapiens	PI3-kinase p110-gamma subunit	4.9	4.9	4.9	pIC50	1
Homo sapiens	Platelet-derived growth factor receptor alpha	6.9	6.9	6.9	pIC50	1
Homo sapiens	Platelet-derived growth factor receptor alpha	9.1	9.1	9.1	pKd	3
Homo sapiens	Platelet-derived growth factor receptor beta	7.1	4.1	8.7	pIC50	16
Homo sapiens	Platelet-derived growth factor receptor beta	9.7	8.4	10.1	pKd	6
Homo sapiens	Platelet-derived growth factor receptor beta	8.1	8.1	8.1	pKi	1
Homo sapiens	Protein kinase C alpha	5.2	5.2	5.2	pKd	1
Homo sapiens	Protein kinase C mu	6.5	6.5	6.5	pKd	3
Homo sapiens	Protein kinase C nu	6.6	5.8	6.6	pKd	4
Homo sapiens	Protein kinase C theta	5.4	5.4	5.4	pKd	3
Homo sapiens	Protein kinase N1	6.2	6.2	6.2	pKd	3
Homo sapiens	Protein kinase N2	5.9	5.9	5.9	pKd	3
Homo sapiens	Protein tyrosine kinase 2 beta	7.1	7.1	7.1	pKd	3
Homo sapiens	Proto-oncogene tyrosine-protein kinase MER	7.6	7.6	7.6	pKd	3
Homo sapiens	Putative uncharacterized serine/threonine-protein kinase SgK110	5.7	5.7	5.7	pKd	2
Homo sapiens	Receptor-interacting serine/threonine-protein kinase 1	6.4	6.4	6.4	pKd	3
Homo sapiens	Receptor-interacting serine/threonine-protein kinase 4	5.7	5.7	5.7	pKd	2
Homo sapiens	Rho-associated protein kinase 1	6.3	6.3	6.3	pKd	2
Homo sapiens	Rho-associated protein kinase 2	6.9	6.9	6.9	pKd	2
Homo sapiens	Rhodopsin kinase	6.5	6.5	6.5	pKd	2
Homo sapiens	Ribosomal protein S6 kinase 1	6.7	6.7	7.3	pKd	2
Homo sapiens	Ribosomal protein S6 kinase alpha 1	6.9	6.9	6.9	pIC50	2
Homo sapiens	Ribosomal protein S6 kinase alpha 1	6.2	5.3	7	pKd	14
Homo sapiens	Ribosomal protein S6 kinase alpha 2	7.2	5.1	7.8	pKd	16
Homo sapiens	Ribosomal protein S6 kinase alpha 3	6.7	6.7	6.7	pIC50	2
Homo sapiens	Ribosomal protein S6 kinase alpha 3	6.2	5.7	7.3	pKd	12
Homo sapiens	Ribosomal protein S6 kinase alpha 4	6.2	5.3	7	pKd	14
Homo sapiens	Ribosomal protein S6 kinase alpha 5	6.6	5.1	7.8	pKd	18
Homo sapiens	Ribosomal protein S6 kinase alpha 6	5.6	5.6	5.6	pKd	6
Homo sapiens	Serine/threonine-protein kinase 10	7.7	5.4	7.7	pKd	5
Homo sapiens	Serine/threonine-protein kinase 11	7.4	7.4	7.4	pKd	3
Homo sapiens	Serine/threonine-protein kinase 16	6.6	6.4	6.6	pKd	5
Homo sapiens	Serine/threonine-protein kinase 17A	9	7.7	9	pKd	5
Homo sapiens	Serine/threonine-protein kinase 17B	7	6.7	7	pKd	5
Homo sapiens	Serine/threonine-protein kinase 2	7.1	5.5	7.3	pKd	6
Homo sapiens	Serine/threonine-protein kinase 24	7.2	5.4	7.2	pKd	4
Homo sapiens	Serine/threonine-protein kinase 25	6.5	6.5	6.5	pKd	3
Homo sapiens	Serine/threonine-protein kinase 33	7.8	7.8	7.8	pKd	3
Homo sapiens	Serine/threonine-protein kinase 35	5.9	5.9	5.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase 38	6.4	6.4	6.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase 38-like	6	5.8	6	pKd	4
Homo sapiens	Serine/threonine-protein kinase AKT2	5.6	5.6	5.6	pKd	3
Homo sapiens	Serine/threonine-protein kinase Aurora-A	5.7	5.7	5.7	pIC50	1
Homo sapiens	Serine/threonine-protein kinase Aurora-A	5.8	5.2	5.8	pKd	4
Homo sapiens	Serine/threonine-protein kinase Aurora-B	5.8	5.8	5.8	pIC50	1
Homo sapiens	Serine/threonine-protein kinase Aurora-B	6.4	5.7	6.4	pKd	4
Homo sapiens	Serine/threonine-protein kinase Aurora-C	6.7	6.5	6.7	pKd	5
Homo sapiens	Serine/threonine-protein kinase Chk1	7.1	7.1	7.1	pIC50	1
Homo sapiens	Serine/threonine-protein kinase Chk1	6.5	5.5	6.5	pKd	4
Homo sapiens	Serine/threonine-protein kinase Chk2	7.8	7.8	7.8	pIC50	1
Homo sapiens	Serine/threonine-protein kinase Chk2	8	8	8.2	pKd	2
Homo sapiens	Serine/threonine-protein kinase c-TAK1	6.4	5.6	6.4	pKd	5
Homo sapiens	Serine/threonine-protein kinase D2	6.4	6	6.4	pKd	4
Homo sapiens	Serine/threonine-protein kinase DCLK1	6.4	6.4	6.4	pKd	3
Homo sapiens	Serine/threonine-protein kinase DCLK2	5.6	5.6	5.6	pKd	3
Homo sapiens	Serine/threonine-protein kinase DCLK3	7	7	7	pKd	3
Homo sapiens	Serine/threonine-protein kinase/endoribonuclease IRE1	6.2	6.2	6.2	pKd	2
Homo sapiens	Serine/threonine-protein kinase GAK	6.9	5.9	7.7	pKd	6
Homo sapiens	Serine/threonine-protein kinase ICK	6.3	6.3	6.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase LATS1	6.2	6.1	6.2	pKd	4
Homo sapiens	Serine/threonine-protein kinase LATS2	6.3	6.3	6.3	pKd	3
Homo sapiens	Serine/threonine-protein kinase MARK1	5.9	5.9	5.9	pKd	3
Homo sapiens	Serine/threonine-protein kinase MST1	7	5.9	7.7	pKd	6
Homo sapiens	Serine/threonine-protein kinase MST2	7.3	5.6	7.3	pKd	4
Mus musculus	Serine/threonine-protein kinase MST2	6.8	6.8	6.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase MST4	6.5	5.7	6.5	pKd	4
Homo sapiens	Serine/threonine-protein kinase NEK2	4.9	4.9	4.9	pIC50	1
Homo sapiens	Serine/threonine-protein kinase NEK2	5.9	5.9	6.3	pKd	5
Homo sapiens	Serine/threonine-protein kinase NEK7	5.4	5.4	5.4	pKd	3
Homo sapiens	Serine/threonine-protein kinase NIM1	6.1	6.1	6.1	pKd	2
Homo sapiens	Serine/threonine-protein kinase OSR1	6.3	6.3	6.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase PAK 3	7.8	7.8	7.8	pKd	3
Homo sapiens	Serine/threonine-protein kinase PAK 4	6.3	6.3	6.3	pIC50	1
Homo sapiens	Serine/threonine-protein kinase PAK 4	5.6	5.6	5.6	pKd	3
Homo sapiens	Serine/threonine-protein kinase PAK 4	6.3	6.3	6.3	pKi	1
Homo sapiens	Serine/threonine-protein kinase PAK6	5.6	5.6	5.6	pKd	3
Homo sapiens	Serine/threonine-protein kinase PAK6	6.3	6.3	6.3	pKi	1
Homo sapiens	Serine/threonine-protein kinase PAK7	6.2	6.2	6.2	pKd	3
Homo sapiens	Serine/threonine-protein kinase PAK7	6.3	6.3	6.3	pKi	1
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-1	6.8	5.6	6.9	pKd	6
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-2	5.9	5.5	5.9	pKd	4
Homo sapiens	Serine/threonine-protein kinase PCTAIRE-3	5.8	5.8	5.8	pKd	3
Homo sapiens	Serine/threonine-protein kinase PFTAIRE-1	6.6	6.6	6.6	pKd	3
Homo sapiens	Serine/threonine-protein kinase PIM2	5.3	5.3	5.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase PIM3	5.6	5.6	5.6	pKd	3
Mycobacterium tuberculosis	Serine/threonine-protein kinase pknB	7.1	7.1	7.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase PLK2	5.3	5.3	5.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase PLK4	6.7	6.4	6.7	pKd	5
Homo sapiens	Serine/threonine-protein kinase PRP4 homolog	6.4	6.4	6.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase RIO1	7.5	7.5	7.5	pKd	3
Homo sapiens	Serine/threonine-protein kinase RIO2	7.3	7.3	7.3	pKd	2
Homo sapiens	Serine/threonine-protein kinase RIO3	5.4	5.4	5.4	pKd	3
Homo sapiens	Serine/threonine-protein kinase SBK1	6.7	6.7	6.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase Sgk3	6.7	6.7	6.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase SIK1	5.5	5.5	5.5	pKd	3
Homo sapiens	Serine/threonine-protein kinase SIK2	6.2	6.2	6.2	pKd	3
Homo sapiens	Serine/threonine-protein kinase SRPK1	6.6	6.6	6.6	pKd	3
Homo sapiens	Serine/threonine-protein kinase SRPK2	6.7	6.7	6.7	pKd	3
Homo sapiens	Serine/threonine-protein kinase SRPK3	7.2	7.2	7.2	pKd	2
Homo sapiens	Serine/threonine-protein kinase TAO1	6.1	6.1	6.1	pKd	2
Homo sapiens	Serine/threonine-protein kinase TAO3	6.7	6.7	6.7	pKd	2
Homo sapiens	Serine/threonine-protein kinase TBK1	6.9	5.8	6.9	pKd	3
Homo sapiens	Serine/threonine-protein kinase tousled-like 1	6.1	6.1	6.1	pKd	3
Homo sapiens	Serine/threonine-protein kinase tousled-like 2	6.5	6.5	6.5	pKd	3
Homo sapiens	Serine/threonine-protein kinase ULK1	7.6	5.7	7.6	pKd	3
Homo sapiens	Serine/threonine-protein kinase ULK2	7.9	7.9	7.9	pKd	2
Homo sapiens	Serine/threonine-protein kinase ULK3	7.4	6	7.4	pKd	3
Homo sapiens	Serine/threonine-protein kinase WEE1	6	6	6	pKd	3
Homo sapiens	SNF-related serine/threonine-protein kinase	6.2	6.2	6.2	pKd	1
Homo sapiens	SPS1/STE20-related protein kinase YSK4	7.8	7.8	7.8	pKd	2
Homo sapiens	STE20/SPS1-related proline-alanine-rich protein kinase	6.9	6.9	6.9	pKd	2
Homo sapiens	Stem cell growth factor receptor	7.3	5.5	9.2	pIC50	16
Homo sapiens	Stem cell growth factor receptor	9.4	6.4	9.7	pKd	23
Homo sapiens	Stem cell growth factor receptor	8.4	8.4	8.4	pKi	1
Homo sapiens	Testis-specific serine/threonine-protein kinase 1	5.2	5.2	5.2	pKd	3
Homo sapiens	TRAF2- and NCK-interacting kinase	7.6	6.4	7.6	pKd	7
Homo sapiens	Tyrosine kinase non-receptor protein 2	5.1	5.1	5.7	pKd	3
Homo sapiens	Tyrosine-protein kinase ABL	6.3	5.8	6.4	pIC50	3
Homo sapiens	Tyrosine-protein kinase ABL	6.1	5.4	7.3	pKd	36
Homo sapiens	Tyrosine-protein kinase ABL2	6	5.9	6	pKd	4
Homo sapiens	Tyrosine-protein kinase BLK	7.2	7.2	7.2	pKd	3
Homo sapiens	Tyrosine-protein kinase BRK	5.3	5.3	5.3	pKd	1
Homo sapiens	Tyrosine-protein kinase BTK	5.7	5.7	5.7	pKd	1
Homo sapiens	Tyrosine-protein kinase CTK	5.1	5.1	5.1	pKd	1
Homo sapiens	Tyrosine-protein kinase FER	6	5.7	6	pKd	5
Homo sapiens	Tyrosine-protein kinase FES	6	6	6	pKd	3
Homo sapiens	Tyrosine-protein kinase FGR	6.5	5.8	6.6	pKd	6
Homo sapiens	Tyrosine-protein kinase FRK	6.3	6.3	6.3	pKd	3
Homo sapiens	Tyrosine-protein kinase FYN	6.3	5.4	6.3	pKd	4
Homo sapiens	Tyrosine-protein kinase HCK	6.7	6.7	6.7	pIC50	1
Homo sapiens	Tyrosine-protein kinase HCK	6.1	5.5	6.1	pKd	5
Homo sapiens	Tyrosine-protein kinase ITK/TSK	7.9	7.9	7.9	pKd	3
Homo sapiens	Tyrosine-protein kinase JAK1	7.3	5.2	8.1	pKd	16
Homo sapiens	Tyrosine-protein kinase JAK2	6.4	6	6.4	pKd	8
Homo sapiens	Tyrosine-protein kinase JAK3	5.9	5.9	5.9	pKd	6
Homo sapiens	Tyrosine-protein kinase LCK	8.1	8.1	8.1	pIC50	1
Homo sapiens	Tyrosine-protein kinase LCK	6.6	5.8	6.6	pKd	5
Homo sapiens	Tyrosine-protein kinase Lyn	6.3	5.9	6.6	pKd	6
Homo sapiens	Tyrosine-protein kinase receptor FLT3	7.7	6.3	8.6	pIC50	14
Homo sapiens	Tyrosine-protein kinase receptor FLT3	9	8	9.7	pKd	25
Homo sapiens	Tyrosine-protein kinase receptor RET	6.7	5.9	6.7	pIC50	3
Homo sapiens	Tyrosine-protein kinase receptor RET	7.9	7.5	8.2	pKd	11
Homo sapiens	Tyrosine-protein kinase receptor Tie-1	5.4	5.4	5.4	pKd	1
Homo sapiens	Tyrosine-protein kinase receptor TYRO3	7.3	7.3	7.3	pKd	3
Homo sapiens	Tyrosine-protein kinase receptor UFO	8.1	8.1	8.1	pIC50	2
Homo sapiens	Tyrosine-protein kinase receptor UFO	8.1	8.1	8.1	pKd	3
Gallus gallus	Tyrosine-protein kinase SRC	6.3	6.3	6.3	pIC50	1
Homo sapiens	Tyrosine-protein kinase SRC	6.4	6.4	6.8	pIC50	2
Homo sapiens	Tyrosine-protein kinase SRC	5.7	5.5	5.7	pKd	4
Homo sapiens	Tyrosine-protein kinase TYK2	5.8	5.8	6.4	pKd	10
Homo sapiens	Tyrosine-protein kinase YES	6.9	6.1	6.9	pKd	5
Mus musculus	ULK3 kinase	7	7	7	pKd	1
Homo sapiens	Vascular endothelial growth factor receptor 1	9	9	9	pIC50	1
Homo sapiens	Vascular endothelial growth factor receptor 1	8.7	8.7	8.7	pKd	3
Homo sapiens	Vascular endothelial growth factor receptor 1	8.7	8.7	8.7	pKi	1
Homo sapiens	Vascular endothelial growth factor receptor 2	7.4	4.7	8.4	pIC50	49
Homo sapiens	Vascular endothelial growth factor receptor 2	8.8	7.5	9.7	pKd	6
Homo sapiens	Vascular endothelial growth factor receptor 2	8.1	8.1	8.5	pKi	4
Homo sapiens	Vascular endothelial growth factor receptor 3	8.1	8.1	8.1	pIC50	1
Homo sapiens	Vascular endothelial growth factor receptor 3	7.3	7.3	7.5	pKd	5
Homo sapiens	Vascular endothelial growth factor receptor 3	7.8	7.8	7.8	pKi	1