4QMW - chain A (model B) | Serine/threonine kinase 24
Structure information
PDB: | 4QMW |
PubMed: | 27135311 |
Release date: | 2015-07-01 |
Resolution: | 1.6 Å |
Kinase: | STK24 (MST3) |
Family: | STE20 |
Group: | STE |
Species: | HUMAN |
Quality Score: | 8 |
Missing Residues: | 0 |
Missing Atoms: | 0 |
DFG conformation: | in |
αC-helix conformation: | in |
Salt bridge KIII.17 and EαC.24: | Yes (2.4Å) |
ASP rotation (xDFG.81) : | 341° |
PHE rotation (xDFG.82) : | 15° |
Activation loop position: | -3.2Å |
αC-helix position: | 17.2Å |
G-rich loop angle: | 59.2° |
G-rich loop distance: | 17.2Å |
G-rich loop rotation: | 67.4° |
Other models from this PDB:
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I1
No H-bonds
I2
H-bond protein
I3
No H-bonds
I7
H-bond ligand
I10
H-bond protein
Binding pocket sequence
Uniprot | EKIGKGSFGEVFKVAIKIIDIQQEITVLSQCDPYVTKYYGSWIIMEYLGGGSALDLLEPYLHSEKKIHRDIKAANVLLLADFGVA |
Structure: | EKIGKGSFGEVFKVAIKIIDIQQEITVLSQCDPYVTKYYGSWIIMEYLGGGSALDLLEPYLHSEKKIHRDIKAANVLLLADFGVA |
Modified residues
Residue 178 (not in pocket)
Phosphorylated threonine
Orthosteric ligand
Ligand HET-code: KS1
Ligand Name: 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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- LABELS
- KLIFS residue #
- Amino Acid
- None
- COLORS
- Interaction types
- KLIFS (all res.)
- KLIFS (interacting res.)
- None
- OTHER
- Show/hide non-interacting res.
- En/disable resizing interacting res.
This ligand targets the following (sub)pockets:
Main pockets | |
---|---|
Front | |
Gate | |
Back |
Subpockets | |
---|---|
FP-I | |
FP-II | |
BP-I-A | |
BP-I-B | |
BP-II-in | |
BP-II-A-in | |
BP-II-B-in | |
BP-II-out | |
BP-II-B | |
BP-III | |
BP-IV | |
BP-V |
Kinase-ligand interactions
■ Hydrophobic ♦ Aromatic face-to-face ♦ Aromatic face-to-edge ▲ H-bond donor ▲ H-bond acceptor ● Ionic positive ● Ionic negative
I | g.l | II | III | αC | |||||||||||||||
1 E 28 | 2 K 29 | 3 I 30 | 4 G 31 | 5 K 32 | 6 G 33 | 7 S 34 | 8 F 35 | 9 G 36 | 10 E 37 | 11 V 38 | 12 F 39 | 13 K 40 | 14 V 50 | 15 A 51 | 16 I 52 | 17 K 53 | 18 I 54 | 19 I 55 | 20 D 66 |
■ | ■ | ■ | ■ | ■ | ■▲ | ||||||||||||||
αC | b.l | IV | |||||||||||||||||
21 I 67 | 22 Q 68 | 23 Q 69 | 24 E 70 | 25 I 71 | 26 T 72 | 27 V 73 | 28 L 74 | 29 S 75 | 30 Q 76 | 31 C 77 | 32 D 78 | 33 P 80 | 34 Y 81 | 35 V 82 | 36 T 83 | 37 K 84 | 38 Y 85 | 39 Y 86 | 40 G 87 |
■▲ | ■ | ■ | |||||||||||||||||
IV | V | GK | hinge | linker | αD | αE | |||||||||||||
41 S 88 | 42 W 96 | 43 I 97 | 44 I 98 | 45 M 99 | 46 E 100 | 47 Y 101 | 48 L 102 | 49 G 103 | 50 G 104 | 51 G 105 | 52 S 106 | 53 A 107 | 54 L 108 | 55 D 109 | 56 L 110 | 57 L 111 | 58 E 112 | 59 P 113 | 60 Y 134 |
■ | ▲ | ■♦ | ■▲ | ||||||||||||||||
αE | VI | c.l | VII | VIII | x | ||||||||||||||
61 L 135 | 62 H 136 | 63 S 137 | 64 E 138 | 65 K 139 | 66 K 140 | 67 I 141 | 68 H 142 | 69 R 143 | 70 D 144 | 71 I 145 | 72 K 146 | 73 A 147 | 74 A 148 | 75 N 149 | 76 V 150 | 77 L 151 | 78 L 152 | 79 L 160 | 80 A 161 |
■ | ■ | ||||||||||||||||||
DFG | a.l | ||||||||||||||||||
81 D 162 | 82 F 163 | 83 G 164 | 84 V 165 | 85 A 166 | |||||||||||||||
■ | ■♦ |
Binding affinities
ChEMBL ID:CHEMBL1081312Bioaffinities: 76 records for 59 kinase(s)
Species | Kinase (ChEMBL naming) | Median | Min | Max | Type | Records |
---|---|---|---|---|---|---|
Homo sapiens | Activin receptor type-1 | 7.2 | 7.2 | 7.2 | pKi | 1 |
Homo sapiens | ALK tyrosine kinase receptor | 6.2 | 6.2 | 6.2 | pKi | 1 |
Homo sapiens | AMP-activated protein kinase, alpha-1 subunit | 5.6 | 5.6 | 5.6 | pKi | 1 |
Homo sapiens | cAMP-dependent protein kinase alpha-catalytic subunit | 6.1 | 6.1 | 6.1 | pKi | 1 |
Homo sapiens | Casein kinase I alpha | 7.4 | 7.4 | 7.4 | pKi | 1 |
Homo sapiens | Cell division protein kinase 8 | 5.9 | 5.9 | 5.9 | pKi | 1 |
Homo sapiens | c-Jun N-terminal kinase 1 | 5.6 | 5.6 | 5.6 | pKi | 1 |
Homo sapiens | c-Jun N-terminal kinase 2 | 5.9 | 5.9 | 5.9 | pKi | 1 |
Homo sapiens | Cyclin-dependent kinase 5 | 5.9 | 5.9 | 5.9 | pKi | 1 |
Homo sapiens | Death-associated protein kinase 3 | 5.3 | 5.3 | 5.3 | pKi | 1 |
Homo sapiens | DNA-dependent protein kinase | 7.2 | 7.2 | 7.2 | pIC50 | 1 |
Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | 6.4 | 6.4 | 6.4 | pKi | 1 |
Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 2 | 6 | 6 | 6 | pKi | 1 |
Homo sapiens | Dual specificity protein kinase CLK2 | 6 | 6 | 6 | pKi | 1 |
Homo sapiens | Dual specificity protein kinase CLK4 | 6.1 | 6.1 | 6.1 | pKi | 1 |
Homo sapiens | Ephrin type-B receptor 4 | 6.7 | 6.7 | 6.7 | pIC50 | 1 |
Homo sapiens | Epidermal growth factor receptor erbB1 | 6.6 | 6.6 | 6.6 | pIC50 | 2 |
Homo sapiens | Fibroblast growth factor receptor 1 | 7 | 7 | 7 | pKi | 1 |
Homo sapiens | Focal adhesion kinase 1 | 5.9 | 5.9 | 5.9 | pKi | 1 |
Homo sapiens | Glycogen synthase kinase-3 alpha | 5.7 | 5.7 | 5.7 | pKi | 1 |
Homo sapiens | Inhibitor of nuclear factor kappa B kinase epsilon subunit | 5.8 | 5.8 | 5.8 | pKi | 1 |
Homo sapiens | Insulin-like growth factor I receptor | 6.4 | 6.4 | 6.4 | pKi | 1 |
Homo sapiens | Leucine-rich repeat serine/threonine-protein kinase 2 | 7.2 | 7.2 | 7.2 | pKi | 1 |
Homo sapiens | Leukocyte tyrosine kinase receptor | 6.8 | 6.8 | 6.8 | pKi | 1 |
Homo sapiens | LIM domain kinase 1 | 6.8 | 6.8 | 6.8 | pKi | 1 |
Homo sapiens | Macrophage colony stimulating factor receptor | 6.4 | 6.4 | 6.4 | pKi | 1 |
Homo sapiens | Macrophage-stimulating protein receptor | 6.9 | 6.9 | 6.9 | pKi | 1 |
Homo sapiens | MAP kinase p38 alpha | 5.6 | 5.6 | 5.6 | pKi | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 2 | 6.5 | 6.5 | 6.5 | pKi | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 4 | 6.2 | 6.2 | 6.2 | pKi | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 5 | 5.9 | 5.9 | 5.9 | pKi | 1 |
Homo sapiens | PI3-kinase p110-alpha subunit | 7.3 | 7.3 | 7.3 | pIC50 | 3 |
Homo sapiens | PI3-kinase p110-beta subunit | 5.9 | 5.9 | 5.9 | pIC50 | 2 |
Homo sapiens | PI3-kinase p110-delta subunit | 6.8 | 6.8 | 6.8 | pIC50 | 2 |
Homo sapiens | PI3-kinase p110-gamma subunit | 6 | 6 | 6 | pIC50 | 2 |
Homo sapiens | PI4-kinase beta subunit | 7.2 | 7.2 | 7.2 | pIC50 | 1 |
Homo sapiens | Platelet-derived growth factor receptor alpha | 6.5 | 6.5 | 6.5 | pKi | 1 |
Homo sapiens | Platelet-derived growth factor receptor beta | 6.4 | 6.4 | 6.4 | pKi | 1 |
Homo sapiens | Protein kinase C nu | 6.6 | 6.6 | 6.6 | pKi | 1 |
Homo sapiens | Protein kinase C theta | 6.3 | 6.3 | 6.3 | pKi | 1 |
Homo sapiens | Rho-associated protein kinase 1 | 6.7 | 6.7 | 6.7 | pKi | 1 |
Homo sapiens | Rho-associated protein kinase 2 | 7.4 | 7.4 | 7.4 | pKi | 1 |
Homo sapiens | Serine-protein kinase ATR | 5.9 | 5.9 | 5.9 | pIC50 | 1 |
Homo sapiens | Serine/threonine-protein kinase c-TAK1 | 6.1 | 6.1 | 6.1 | pKi | 1 |
Homo sapiens | Serine/threonine-protein kinase mTOR | 8 | 8 | 8 | pIC50 | 2 |
Homo sapiens | Serine/threonine-protein kinase PAK 4 | 6.2 | 6.2 | 6.2 | pKi | 1 |
Homo sapiens | Serine/threonine-protein kinase TAO1 | 5.6 | 5.6 | 5.6 | pKi | 1 |
Homo sapiens | Tyrosine kinase non-receptor protein 2 | 6.4 | 6.4 | 6.4 | pKi | 1 |
Homo sapiens | Tyrosine-protein kinase ABL | 7.8 | 7.8 | 8.7 | pIC50 | 3 |
Homo sapiens | Tyrosine-protein kinase ABL | 7.8 | 7.8 | 7.8 | pKi | 1 |
Homo sapiens | Tyrosine-protein kinase BTK | 5.8 | 5.8 | 5.8 | pKi | 1 |
Homo sapiens | Tyrosine-protein kinase FYN | 7.1 | 7.1 | 7.1 | pKi | 1 |
Homo sapiens | Tyrosine-protein kinase HCK | 8.1 | 8.1 | 8.1 | pIC50 | 2 |
Homo sapiens | Tyrosine-protein kinase JAK2 | 6 | 6 | 6 | pKi | 2 |
Homo sapiens | Tyrosine-protein kinase LCK | 6.8 | 6.8 | 6.8 | pKi | 1 |
Homo sapiens | Tyrosine-protein kinase receptor RET | 8.9 | 8.9 | 8.9 | pKi | 1 |
Homo sapiens | Tyrosine-protein kinase receptor TYRO3 | 6.1 | 6.1 | 6.1 | pKi | 1 |
Homo sapiens | Tyrosine-protein kinase SRC | 7.9 | 7.9 | 7.9 | pIC50 | 3 |
Homo sapiens | Vascular endothelial growth factor receptor 1 | 7.2 | 7.2 | 7.2 | pKi | 1 |
Homo sapiens | Vascular endothelial growth factor receptor 2 | 7.9 | 7.4 | 7.9 | pIC50 | 3 |
Homo sapiens | Vascular endothelial growth factor receptor 2 | 8.3 | 8.3 | 8.3 | pKi | 1 |