3A7F - chain A | Serine/threonine kinase 24
Structure information
PDB: | 3A7F |
PubMed: | 20124694 |
Release date: | 2010-02-02 |
Resolution: | 1.55 Å |
Kinase: | STK24 (MST3) |
Family: | STE20 |
Group: | STE |
Species: | HUMAN |
Quality Score: | 8 |
Missing Residues: | 0 |
Missing Atoms: | 0 |
DFG conformation: | in |
αC-helix conformation: | in |
Salt bridge KIII.17 and EαC.24: | Yes (3.1Å) |
ASP rotation (xDFG.81) : | 21° |
PHE rotation (xDFG.82) : | 16° |
Activation loop position: | -3.2Å |
αC-helix position: | 18.3Å |
G-rich loop angle: | 55.6° |
G-rich loop distance: | 15.7Å |
G-rich loop rotation: | 93.4° |
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I2
H-bond protein
I4
H-bond protein
I5
H-bond protein
I6
No H-bonds
I7
No H-bonds
Binding pocket sequence
Uniprot | EKIGKGSFGEVFKVAIKIIDIQQEITVLSQCDPYVTKYYGSWIIMEYLGGGSALDLLEPYLHSEKKIHRDIKAANVLLLADFGVA |
Structure: | EKIGKGSFGEVFKVAIKIIDIQQEITVLSQCDPYVTKYYGSWIIMEYLGGGSALDLLEPYLHSEKKIHRDIKAANVLLLADFGVA |
Modified residues
Residue 178 (not in pocket)
Phosphorylated threonine