4QMU - chain A (model B) | Serine/threonine kinase 24
Structure information
| PDB: | 4QMU |
| PubMed: | 27135311 |
| Release date: | 2015-07-01 |
| Resolution: | 1.55 Å |
| Kinase: | STK24 (MST3) |
| Family: | STE20 |
| Group: | STE |
| Species: | HUMAN |
| Quality Score: | 8 |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| DFG conformation: | in |
| αC-helix conformation: | in |
| Salt bridge KIII.17 and EαC.24: | Yes (2.6Å) |
| ASP rotation (xDFG.81) : | 4° |
| PHE rotation (xDFG.82) : | 14° |
| Activation loop position: | -3.2Å |
| αC-helix position: | 17.5Å |
| G-rich loop angle: | 60.5° |
| G-rich loop distance: | 17.5Å |
| G-rich loop rotation: | 72.7° |
Other models from this PDB:
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I1
H-bond protein
I4
H-bond protein
I5
H-bond ligand
H-bond protein
I11
H-bond ligand
H-bond protein
Binding pocket sequence
| Uniprot | EKIGKGSFGEVFKVAIKIIDIQQEITVLSQCDPYVTKYYGSWIIMEYLGGGSALDLLEPYLHSEKKIHRDIKAANVLLLADFGVA |
| Structure: | EKIGKGSFGEVFKVAIKIIDIQQEITVLSQCDPYVTKYYGSWIIMEYLGGGSALDLLEPYLHSEKKIHRDIKAANVLLLADFGVA |
Modified residues
Residue 178 (not in pocket)
Phosphorylated threonine
Orthosteric ligand
Ligand HET-code: SKE
Ligand Name: 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide
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- LABELS
- KLIFS residue #
- Amino Acid
- None
- COLORS
- Interaction types
- KLIFS (all res.)
- KLIFS (interacting res.)
- None
- OTHER
- Show/hide non-interacting res.
- En/disable resizing interacting res.
This ligand targets the following (sub)pockets:
| Main pockets | |
|---|---|
| Front | |
| Gate | |
| Back | |
| Subpockets | |
|---|---|
| FP-I | |
| FP-II | |
| BP-I-A | |
| BP-I-B | |
| BP-II-in | |
| BP-II-A-in | |
| BP-II-B-in | |
| BP-II-out | |
| BP-II-B | |
| BP-III | |
| BP-IV | |
| BP-V | |
Kinase-ligand interactions
■ Hydrophobic ♦ Aromatic face-to-face ♦ Aromatic face-to-edge ▲ H-bond donor ▲ H-bond acceptor ● Ionic positive ● Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 E 28 | 2 K 29 | 3 I 30 | 4 G 31 | 5 K 32 | 6 G 33 | 7 S 34 | 8 F 35 | 9 G 36 | 10 E 37 | 11 V 38 | 12 F 39 | 13 K 40 | 14 V 50 | 15 A 51 | 16 I 52 | 17 K 53 | 18 I 54 | 19 I 55 | 20 D 66 |
| ■ | ■ | ■ | ■ | ||||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 I 67 | 22 Q 68 | 23 Q 69 | 24 E 70 | 25 I 71 | 26 T 72 | 27 V 73 | 28 L 74 | 29 S 75 | 30 Q 76 | 31 C 77 | 32 D 78 | 33 P 80 | 34 Y 81 | 35 V 82 | 36 T 83 | 37 K 84 | 38 Y 85 | 39 Y 86 | 40 G 87 |
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 S 88 | 42 W 96 | 43 I 97 | 44 I 98 | 45 M 99 | 46 E 100 | 47 Y 101 | 48 L 102 | 49 G 103 | 50 G 104 | 51 G 105 | 52 S 106 | 53 A 107 | 54 L 108 | 55 D 109 | 56 L 110 | 57 L 111 | 58 E 112 | 59 P 113 | 60 Y 134 |
| ▲ | ■♦ | ■▲▲ | ■ | ■ | ▲ | ||||||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 L 135 | 62 H 136 | 63 S 137 | 64 E 138 | 65 K 139 | 66 K 140 | 67 I 141 | 68 H 142 | 69 R 143 | 70 D 144 | 71 I 145 | 72 K 146 | 73 A 147 | 74 A 148 | 75 N 149 | 76 V 150 | 77 L 151 | 78 L 152 | 79 L 160 | 80 A 161 |
| ■ | ■ | ||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 162 | 82 F 163 | 83 G 164 | 84 V 165 | 85 A 166 | |||||||||||||||
| ■ | |||||||||||||||||||
Binding affinities
ChEMBL ID:CHEMBL191003Bioaffinities: 259 records for 154 kinase(s)
| Species | Kinase (ChEMBL naming) | Median | Min | Max | Type | Records |
|---|---|---|---|---|---|---|
| Homo sapiens | 3-phosphoinositide dependent protein kinase-1 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Activin receptor type-1 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Activin receptor type-1 | 5.5 | 5.5 | 5.5 | pKi | 1 |
| Homo sapiens | Activin receptor type-2A | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Activin receptor type-2B | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Adaptor-associated kinase | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | ALK tyrosine kinase receptor | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | ALK tyrosine kinase receptor | 5.9 | 5.9 | 5.9 | pKi | 1 |
| Homo sapiens | AMP-activated protein kinase, alpha-1 subunit | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | AMP-activated protein kinase, alpha-1 subunit | 6.3 | 6.3 | 6.3 | pKi | 1 |
| Homo sapiens | AMP-activated protein kinase, alpha-2 subunit | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Ankyrin repeat and protein kinase domain-containing protein 1 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | BMP-2-inducible protein kinase | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Bone morphogenetic protein receptor type-2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | BR serine/threonine-protein kinase 1 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | BR serine/threonine-protein kinase 2 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | CaM-kinase kinase alpha | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | CaM-kinase kinase beta | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | CaM-kinase kinase beta | 7.2 | 7.2 | 7.2 | pKi | 1 |
| Homo sapiens | Casein kinase I epsilon | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Casein kinase I gamma 1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Casein kinase I gamma 2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Casein kinase II alpha (prime) | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Casein kinase I isoform gamma-3 | 5.1 | 5.1 | 5.1 | pKd | 1 |
| Homo sapiens | Chaperone activity of bc1 complex-like, mitochondrial | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | c-Jun N-terminal kinase 1 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | c-Jun N-terminal kinase 1 | 6.2 | 6.2 | 6.2 | pKi | 1 |
| Homo sapiens | c-Jun N-terminal kinase 3 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | c-Jun N-terminal kinase 3 | 6.5 | 6.5 | 6.5 | pKi | 1 |
| Homo sapiens | Cyclin-dependent kinase 1 | 8.2 | 8.2 | 8.2 | pIC50 | 1 |
| Homo sapiens | Cyclin-dependent kinase 2 | 8.7 | 8.7 | 8.7 | pIC50 | 1 |
| Homo sapiens | Cyclin-dependent kinase 2 | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 3 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 5 | 7.9 | 7.9 | 7.9 | pIC50 | 1 |
| Homo sapiens | Cyclin-dependent kinase 5 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 5 | 9.3 | 9.3 | 9.3 | pKi | 1 |
| Homo sapiens | Cyclin-dependent kinase 7 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 7 | 6.2 | 6.2 | 6.2 | pKi | 1 |
| Homo sapiens | Cyclin-dependent kinase 9 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 9 | 7.8 | 7.8 | 7.8 | pKi | 1 |
| Homo sapiens | Death-associated protein kinase 3 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Death-associated protein kinase 3 | 5.7 | 5.7 | 5.7 | pKi | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | 5.7 | 5.7 | 5.7 | pKi | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 2 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 2 | 5.4 | 5.4 | 5.4 | pKi | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 3 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 4 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 6 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK2 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK2 | 6.2 | 6.2 | 6.2 | pKi | 1 |
| Homo sapiens | Dual specificity protein kinase CLK3 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK4 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK4 | 6.7 | 6.7 | 6.7 | pKi | 1 |
| Homo sapiens | Dual specificity protein kinase TTK | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Dual specificity testis-specific protein kinase 1 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Dual specificty protein kinase CLK1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 7 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Eukaryotic translation initiation factor 2-alpha kinase 4 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 1 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 1 | 6.5 | 6.5 | 6.5 | pKi | 1 |
| Homo sapiens | Fibroblast growth factor receptor 2 | 6.7 | 6.7 | 6.7 | pIC50 | 1 |
| Homo sapiens | Fibroblast growth factor receptor 2 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 3 | 6.2 | 6.2 | 6.3 | pKd | 2 |
| Homo sapiens | Glycogen synthase kinase-3 alpha | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Glycogen synthase kinase-3 alpha | 6.8 | 6.8 | 6.8 | pKi | 1 |
| Homo sapiens | Glycogen synthase kinase-3 beta | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Glycogen synthase kinase-3 beta | 6.8 | 6.8 | 6.8 | pKi | 1 |
| Homo sapiens | G protein-coupled receptor kinase 5 | 6 | 6 | 6 | pKi | 1 |
| Homo sapiens | Hepatocyte growth factor receptor | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Hepatocyte growth factor receptor | 6.4 | 6.4 | 6.4 | pKi | 1 |
| Homo sapiens | Inhibitor of nuclear factor kappa B kinase epsilon subunit | 5.1 | 5.1 | 5.1 | pKd | 1 |
| Homo sapiens | Interferon-induced, double-stranded RNA-activated protein kinase | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 3 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Leucine-rich repeat serine/threonine-protein kinase 2 | 7.1 | 7.1 | 7.1 | pKi | 1 |
| Homo sapiens | LIM domain kinase 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | LIM domain kinase 1 | 6.7 | 6.7 | 6.7 | pKi | 1 |
| Homo sapiens | LIM domain kinase 2 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Macrophage colony stimulating factor receptor | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Macrophage colony stimulating factor receptor | 5.9 | 5.9 | 5.9 | pKi | 1 |
| Homo sapiens | Macrophage-stimulating protein receptor | 7 | 7 | 7 | pKi | 1 |
| Homo sapiens | MAP/microtubule affinity-regulating kinase 2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | MAP/microtubule affinity-regulating kinase 4 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | MAP/microtubule affinity-regulating kinase 4 | 7 | 7 | 7 | pKi | 1 |
| Homo sapiens | Maternal embryonic leucine zipper kinase | 6.2 | 6.2 | 6.2 | pKi | 1 |
| Homo sapiens | Mitogen-activated protein kinase 15 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase 4 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase 6 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase 7 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 9 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 1 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 2 | 5.8 | 5.8 | 5.8 | pKi | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 3 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 5 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Myosin light chain kinase, smooth muscle | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Myotonin-protein kinase | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Neurotrophic tyrosine kinase receptor type 2 | 5.7 | 5.7 | 5.7 | pKi | 1 |
| Homo sapiens | NUAK family SNF1-like kinase 1 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | NUAK family SNF1-like kinase 2 | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha | 5 | 5 | 5 | pKd | 1 |
| Homo sapiens | Phosphatidylinositol-5-phosphate 4-kinase type-2 beta | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | PITSLRE serine/threonine-protein kinase CDC2L1 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | PITSLRE serine/threonine-protein kinase CDC2L2 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor alpha | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor beta | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Protein kinase C delta | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Protein kinase C mu | 5.1 | 5.1 | 5.1 | pKd | 1 |
| Homo sapiens | Protein kinase C nu | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Protein kinase C nu | 5.7 | 5.7 | 5.7 | pKi | 1 |
| Homo sapiens | Protein kinase C theta | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Protein kinase N2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase MER | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase ROS | 6.3 | 6.3 | 6.3 | pKi | 1 |
| Homo sapiens | Receptor-interacting serine/threonine-protein kinase 1 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Rho-associated protein kinase 1 | 6.9 | 6.9 | 6.9 | pKi | 1 |
| Homo sapiens | Rho-associated protein kinase 2 | 7.2 | 7.2 | 7.2 | pKi | 1 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 1 | 5.4 | 5.4 | 5.4 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 2 | 6.4 | 6.4 | 6.4 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 3 | 6 | 6 | 6 | pKi | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 4 | 5.5 | 5.5 | 5.5 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase 10 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 16 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 17A | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 2 | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 24 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 25 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-A | 8 | 8 | 8 | pIC50 | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-A | 7.2 | 6.6 | 7.5 | pKd | 6 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-A | 7.3 | 7.3 | 7.3 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-B | 8.4 | 8.4 | 8.4 | pIC50 | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-B | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-B | 7.4 | 7.4 | 7.4 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-C | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase c-TAK1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase c-TAK1 | 6.1 | 6.1 | 6.1 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase DCLK1 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase DCLK2 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase DCLK3 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase GAK | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MARK1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST1 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST2 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST2 | 6.7 | 6.7 | 6.7 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST4 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 3 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 4 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 4 | 5.9 | 5.9 | 5.9 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK6 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK7 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-1 | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-2 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-3 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PFTAIRE-1 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK1 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK3 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK4 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase receptor R3 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RIO1 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RIO3 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK1 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK2 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK2 | 6.6 | 6.6 | 6.6 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase SRPK1 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TAO1 | 7.6 | 7.6 | 7.6 | pKi | 1 |
| Homo sapiens | Serine/threonine-protein kinase TNNI3K | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase tousled-like 1 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase tousled-like 2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Stem cell growth factor receptor | 5.8 | 5.6 | 6.2 | pKd | 6 |
| Homo sapiens | Stem cell growth factor receptor | 7.1 | 7.1 | 7.1 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase ABL | 5.9 | 5.7 | 7.2 | pKd | 7 |
| Homo sapiens | Tyrosine-protein kinase ABL | 6.4 | 6.4 | 6.4 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase BMX | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FGR | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase JAK1 | 7.7 | 7.7 | 7.7 | pKd | 6 |
| Homo sapiens | Tyrosine-protein kinase JAK2 | 5 | 5 | 5.5 | pIC50 | 4 |
| Homo sapiens | Tyrosine-protein kinase JAK2 | 6.7 | 6.1 | 7.5 | pKd | 22 |
| Homo sapiens | Tyrosine-protein kinase JAK2 | 7 | 7 | 7 | pKi | 2 |
| Homo sapiens | Tyrosine-protein kinase JAK3 | 6.8 | 6.8 | 6.8 | pKd | 4 |
| Homo sapiens | Tyrosine-protein kinase JAK3 | 6.7 | 6.7 | 6.7 | pKi | 2 |
| Homo sapiens | Tyrosine-protein kinase LCK | 5.6 | 5.6 | 5.6 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 6.1 | 5.9 | 6.2 | pKd | 5 |
| Homo sapiens | Tyrosine-protein kinase receptor RET | 5.4 | 5.4 | 6 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase receptor RET | 6.2 | 6.2 | 6.2 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor Tie-1 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor TYRO3 | 6.1 | 6.1 | 6.1 | pKi | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor UFO | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase SYK | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TEC | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TIE-2 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TYK2 | 7.5 | 7.5 | 7.5 | pKd | 4 |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | 6 | 6 | 6 | pKi | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 6.9 | 6.9 | 6.9 | pIC50 | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 6.6 | 6.6 | 6.6 | pKi | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 3 | 6 | 6 | 6 | pKd | 1 |