4HPU - chain E (model B) | Protein kinase, cAMP dependent, catalytic, alpha
Structure information
PDB:4HPU
PubMed:23458248
Release date:2013-03-20
Resolution:1.55 Å
 
Kinase:Prkaca (PKACa)
Family:PKA
Group:AGC
Species:MOUSE
 
Quality Score:8
Missing Residues:0
Missing Atoms:0
DFG conformation:in
αC-helix conformation:in
Salt bridge KIII.17 and EαC.24:Yes (2.7Å)
 
 
ASP rotation (xDFG.81) :337°
PHE rotation (xDFG.82) :10°
Activation loop position:-4.1Å
αC-helix position:17.5Å
 
G-rich loop angle:55.1°
G-rich loop distance:17Å
G-rich loop rotation:73.2°
Other models from this PDB:
2D & 3D views

The orthosteric binding pocket
Binding pocket waters
The following waters were found in the defined clusters:
I1
H-bond protein
I4
H-bond protein
I5
H-bond protein
Binding pocket sequence
UniprotKTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVAGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA
Structure:KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVAGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA


Modified residues
Residue 139 (not in pocket)
Phosphorylated serine
Residue 197 (not in pocket)
Phosphorylated threonine
Residue 338 (not in pocket)
Phosphorylated serine