4O22 - chain A (model B) | Protein kinase, cAMP dependent, catalytic, alpha
Structure information
PDB: | 4O22 |
PubMed: | 24786636 |
Release date: | 2014-05-28 |
Resolution: | 1.7 Å |
Kinase: | Prkaca (PKACa) |
Family: | PKA |
Group: | AGC |
Species: | MOUSE |
Quality Score: | 9.5 |
Missing Residues: | 0 |
Missing Atoms: | 5 |
DFG conformation: | in |
αC-helix conformation: | in |
Salt bridge KIII.17 and EαC.24: | Yes (2.6Å) |
ASP rotation (xDFG.81) : | 341° |
PHE rotation (xDFG.82) : | 13° |
Activation loop position: | -4Å |
αC-helix position: | 17.9Å |
G-rich loop angle: | 57.4° |
G-rich loop distance: | 17.7Å |
G-rich loop rotation: | 60.8° |
Other models from this PDB:
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I1
H-bond protein
I3
No H-bonds
I4
H-bond protein
I5
H-bond protein
I6
No H-bonds
I8
H-bond protein
I9
No H-bonds
Binding pocket sequence
Uniprot | KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVAGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA |
Structure: | KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVAGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA |
Modified residues
Residue 139 (not in pocket)
Phosphorylated serine
Residue 197 (not in pocket)
Phosphorylated threonine
Residue 338 (not in pocket)
Phosphorylated serine