4DFZ - chain E (model C) | Protein kinase, cAMP dependent, catalytic, alpha
Structure information
PDB:4DFZ
PubMed:22617327
Release date:2012-06-06
Resolution:2 Å
 
Kinase:Prkaca (PKACa)
Family:PKA
Group:AGC
Species:MOUSE
 
Quality Score:8.9
Missing Residues:0
Missing Atoms:11
DFG conformation:in
αC-helix conformation:in
Salt bridge KIII.17 and EαC.24:Yes (2.7Å)
 
 
ASP rotation (xDFG.81) :345°
PHE rotation (xDFG.82) :11°
Activation loop position:-4.1Å
αC-helix position:17.8Å
 
G-rich loop angle:54.8°
G-rich loop distance:17Å
G-rich loop rotation:63.1°
Other models from this PDB:
2D & 3D views

The orthosteric binding pocket
Binding pocket waters
The following waters were found in the defined clusters:
I1
H-bond protein
I4
H-bond protein
I6
No H-bonds
I8
H-bond protein
Binding pocket sequence
UniprotKTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVAGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA
Structure:KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVAGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA


Modified residues
Residue 139 (not in pocket)
Phosphorylated serine
Residue 197 (not in pocket)
Phosphorylated threonine
Residue 338 (not in pocket)
Phosphorylated serine