4Z55 - chain A (model B) | Anaplastic lymphoma receptor tyrosine kinase
Structure information
PDB: | 4Z55 |
PubMed: | 26750252 |
Release date: | 2016-02-03 |
Resolution: | 1.55 Å |
Kinase: | ALK |
Family: | ALK |
Group: | TK |
Species: | HUMAN |
Quality Score: | 8 |
Missing Residues: | 0 |
Missing Atoms: | 0 |
DFG conformation: | in |
αC-helix conformation: | in |
Salt bridge KIII.17 and EαC.24: | Yes (2.8Å) |
ASP rotation (xDFG.81) : | 6° |
PHE rotation (xDFG.82) : | 18° |
Activation loop position: | -4.5Å |
αC-helix position: | 17.7Å |
G-rich loop angle: | 60.6° |
G-rich loop distance: | 17.9Å |
G-rich loop rotation: | 90.3° |
Other models from this PDB:
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I2
H-bond protein
I4
H-bond protein
I5
H-bond protein
Binding pocket sequence
Uniprot | RGLGHGAFGEVYEVAVKTLDFLMEALIISKFNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA |
Structure: | RGLGHGAFGEVYEVAVKTLDFLMEALIISKFNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA |
Modified residues
No modified residues identified.
Orthosteric ligand
Ligand HET-code: 4LO
Ligand Name: N~6~-[5-methyl-4-(1-methylpiperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N~4~-[2-(propan-2-ylsulfonyl)phenyl]-2H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
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- LABELS
- KLIFS residue #
- Amino Acid
- None
- COLORS
- Interaction types
- KLIFS (all res.)
- KLIFS (interacting res.)
- None
- OTHER
- Show/hide non-interacting res.
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This ligand targets the following (sub)pockets:
Main pockets | |
---|---|
Front | |
Gate | |
Back |
Subpockets | |
---|---|
FP-I | |
FP-II | |
BP-I-A | |
BP-I-B | |
BP-II-in | |
BP-II-A-in | |
BP-II-B-in | |
BP-II-out | |
BP-II-B | |
BP-III | |
BP-IV | |
BP-V |
Kinase-ligand interactions
■ Hydrophobic ♦ Aromatic face-to-face ♦ Aromatic face-to-edge ▲ H-bond donor ▲ H-bond acceptor ● Ionic positive ● Ionic negative
I | g.l | II | III | αC | |||||||||||||||
1 R 1120 | 2 G 1121 | 3 L 1122 | 4 G 1123 | 5 H 1124 | 6 G 1125 | 7 A 1126 | 8 F 1127 | 9 G 1128 | 10 E 1129 | 11 V 1130 | 12 Y 1131 | 13 E 1132 | 14 V 1147 | 15 A 1148 | 16 V 1149 | 17 K 1150 | 18 T 1151 | 19 L 1152 | 20 D 1163 |
■ | ■ | ■ | ■ | ■ | ■ | ■ | ■ | ||||||||||||
αC | b.l | IV | |||||||||||||||||
21 F 1164 | 22 L 1165 | 23 M 1166 | 24 E 1167 | 25 A 1168 | 26 L 1169 | 27 I 1170 | 28 I 1171 | 29 S 1172 | 30 K 1173 | 31 F 1174 | 32 N 1175 | 33 Q 1177 | 34 N 1178 | 35 I 1179 | 36 V 1180 | 37 R 1181 | 38 C 1182 | 39 I 1183 | 40 G 1184 |
IV | V | GK | hinge | linker | αD | αE | |||||||||||||
41 V 1185 | 42 F 1193 | 43 I 1194 | 44 L 1195 | 45 L 1196 | 46 E 1197 | 47 L 1198 | 48 M 1199 | 49 A 1200 | 50 G 1201 | 51 G 1202 | 52 D 1203 | 53 L 1204 | 54 K 1205 | 55 S 1206 | 56 F 1207 | 57 L 1208 | 58 R 1209 | 59 E 1210 | 60 Y 1239 |
■ | ■ | ■▲▲ | ■ | ■ | ■ | ■ | |||||||||||||
αE | VI | c.l | VII | VIII | x | ||||||||||||||
61 L 1240 | 62 E 1241 | 63 E 1242 | 64 N 1243 | 65 H 1244 | 66 F 1245 | 67 I 1246 | 68 H 1247 | 69 R 1248 | 70 D 1249 | 71 I 1250 | 72 A 1251 | 73 A 1252 | 74 R 1253 | 75 N 1254 | 76 C 1255 | 77 L 1256 | 78 L 1257 | 79 I 1268 | 80 G 1269 |
■ | ■ | ||||||||||||||||||
DFG | a.l | ||||||||||||||||||
81 D 1270 | 82 F 1271 | 83 G 1272 | 84 M 1273 | 85 A 1274 | |||||||||||||||
■ |
Binding affinities
Ligand not found in ChEMBL.