5E8S - chain A (model B) | Transforming growth factor beta receptor I
Structure information
PDB:5E8S
PubMed:27139629
Release date:2016-05-11
Resolution:1.45 Å
 
Kinase:TGFBR1 (TGFbR1)
Family:STKR
Group:TKL
Species:HUMAN
 
Quality Score:9.8
Missing Residues:0
Missing Atoms:2
DFG conformation:in
αC-helix conformation:in
Salt bridge KIII.17 and EαC.24:Yes (3.1Å)
 
 
ASP rotation (xDFG.81) :359°
PHE rotation (xDFG.82) :357°
Activation loop position:-3.3Å
αC-helix position:17.5Å
 
G-rich loop angle:54.5°
G-rich loop distance:16.1Å
G-rich loop rotation:61.7°
Other models from this PDB:
2D & 3D views

The orthosteric binding pocket
Binding pocket waters
The following waters were found in the defined clusters:
I1
H-bond protein
I2
H-bond protein
I5
H-bond protein
I8
H-bond protein
Binding pocket sequence
UniprotESIGKGRFGEVWRVAVKIFSWFREAEIYQTVMENILGFIAAWLVSDYHEHGSLFDYLNRTQGKPAIAHRDLKSKNILVIADLGLA
Structure:ESIGKGRFGEVWRVAVKIFSWFREAEIYQTVMENILGFIAAWLVSDYHEHGSLFDYLNRTQGKPAIAHRDLKSKNILVIADLGLA


Modified residues
No modified residues identified.