5E8U - chain A | Transforming growth factor beta receptor I
Structure information
| PDB: | 5E8U |
| PubMed: | 27139629 |
| Release date: | 2016-05-11 |
| Resolution: | 2.03 Å |
| Kinase: | TGFBR1 (TGFbR1) |
| Family: | STKR |
| Group: | TKL |
| Species: | HUMAN |
| Quality Score: | 9.6 |
| Missing Residues: | 0 |
| Missing Atoms: | 4 |
| DFG conformation: | in |
| αC-helix conformation: | in |
| Salt bridge KIII.17 and EαC.24: | Yes (2.9Å) |
| ASP rotation (xDFG.81) : | 358° |
| PHE rotation (xDFG.82) : | 17° |
| Activation loop position: | -3.1Å |
| αC-helix position: | 17.4Å |
| G-rich loop angle: | 49.6° |
| G-rich loop distance: | 14.7Å |
| G-rich loop rotation: | 68.9° |
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I5
H-bond protein
I8
H-bond protein
Binding pocket sequence
| Uniprot | ESIGKGRFGEVWRVAVKIFSWFREAEIYQTVMENILGFIAAWLVSDYHEHGSLFDYLNRTQGKPAIAHRDLKSKNILVIADLGLA |
| Structure: | ESVGKGRFGEVWRVAVKIFSWFREAEIFQTVMENILGFIAAWLVTDFHEHGNLFDYLNRTQGKPAIAHRDLKSKNILVICDFGLA |
Modified residues
No modified residues identified.