5TE0 - chain A | AP2 associated kinase 1
Structure information
| PDB: | 5TE0 |
| PubMed: | - |
| Release date: | 2016-11-02 |
| Resolution: | 1.9 Å |
| Kinase: | AAK1 |
| Family: | NAK |
| Group: | Other |
| Species: | HUMAN |
| Quality Score: | 8.8 |
| Missing Residues: | 0 |
| Missing Atoms: | 12 |
| DFG conformation: | in |
| αC-helix conformation: | in |
| Salt bridge KIII.17 and EαC.24: | Yes (3.5Å) |
| ASP rotation (xDFG.81) : | 356° |
| PHE rotation (xDFG.82) : | 6° |
| Activation loop position: | -3.8Å |
| αC-helix position: | 18.3Å |
| G-rich loop angle: | 58.5° |
| G-rich loop distance: | 18.1Å |
| G-rich loop rotation: | 35° |
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I10
H-bond ligand
H-bond protein
Binding pocket sequence
| Uniprot | EVLAEGGFAIVFLCALKRMVCKREIQIMRDLSKNIVGYIDSLILMDFCRGGQVVNLMNQHQCKTPIIHRDLKVENILLLCDFGSA |
| Structure: | EVLAEGGFAIVFLCALKRMVCKREIQIMRDLSKNIVGYIDSLILMDFCRGGQVVNLMNQHQCKTPIIHRDLKVENILLLCDFGSA |
Modified residues
No modified residues identified.
Orthosteric ligand
Ligand HET-code: XIN
Ligand Name: methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
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- LABELS
- KLIFS residue #
- Amino Acid
- None
- COLORS
- Interaction types
- KLIFS (all res.)
- KLIFS (interacting res.)
- None
- OTHER
- Show/hide non-interacting res.
- En/disable resizing interacting res.
This ligand targets the following (sub)pockets:
| Main pockets | |
|---|---|
| Front | |
| Gate | |
| Back | |
| Subpockets | |
|---|---|
| FP-I | |
| FP-II | |
| BP-I-A | |
| BP-I-B | |
| BP-II-in | |
| BP-II-A-in | |
| BP-II-B-in | |
| BP-II-out | |
| BP-II-B | |
| BP-III | |
| BP-IV | |
| BP-V | |
Kinase-ligand interactions
■ Hydrophobic ♦ Aromatic face-to-face ♦ Aromatic face-to-edge ▲ H-bond donor ▲ H-bond acceptor ● Ionic positive ● Ionic negative
| I | g.l | II | III | αC | |||||||||||||||
| 1 E 50 | 2 V 51 | 3 L 52 | 4 A 53 | 5 E 54 | 6 G 55 | 7 G 56 | 8 F 57 | 9 A 58 | 10 I 59 | 11 V 60 | 12 F 61 | 13 L 62 | 14 C 71 | 15 A 72 | 16 L 73 | 17 K 74 | 18 R 75 | 19 M 76 | 20 V 86 |
| ■▲● | ■ | ■ | ■ | ■ | ■ | ||||||||||||||
| αC | b.l | IV | |||||||||||||||||
| 21 C 87 | 22 K 88 | 23 R 89 | 24 E 90 | 25 I 91 | 26 Q 92 | 27 I 93 | 28 M 94 | 29 R 95 | 30 D 96 | 31 L 97 | 32 S 98 | 33 K 101 | 34 N 102 | 35 I 103 | 36 V 104 | 37 G 105 | 38 Y 106 | 39 I 107 | 40 D 108 |
| ■ | ■ | ||||||||||||||||||
| IV | V | GK | hinge | linker | αD | αE | |||||||||||||
| 41 S 109 | 42 L 123 | 43 I 124 | 44 L 125 | 45 M 126 | 46 D 127 | 47 F 128 | 48 C 129 | 49 R 130 | 50 G 131 | 51 G 132 | 52 Q 133 | 53 V 134 | 54 V 135 | 55 N 136 | 56 L 137 | 57 M 138 | 58 N 139 | 59 Q 140 | 60 H 166 |
| ■ | ▲ | ■♦ | ■▲ | ■ | ■ | ■ | ■ | ■ | |||||||||||
| αE | VI | c.l | VII | VIII | x | ||||||||||||||
| 61 Q 167 | 62 C 168 | 63 K 169 | 64 T 170 | 65 P 171 | 66 I 172 | 67 I 173 | 68 H 174 | 69 R 175 | 70 D 176 | 71 L 177 | 72 K 178 | 73 V 179 | 74 E 180 | 75 N 181 | 76 I 182 | 77 L 183 | 78 L 184 | 79 L 192 | 80 C 193 |
| ■ | ■ | ||||||||||||||||||
| DFG | a.l | ||||||||||||||||||
| 81 D 194 | 82 F 195 | 83 G 196 | 84 S 197 | 85 A 198 | |||||||||||||||
| ■ | ■ | ||||||||||||||||||
Binding affinities
ChEMBL ID:CHEMBL502835Bioaffinities: 368 records for 223 kinase(s)
| Species | Kinase (ChEMBL naming) | Median | Min | Max | Type | Records |
|---|---|---|---|---|---|---|
| Homo sapiens | 3-phosphoinositide dependent protein kinase-1 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Activin receptor type-1 | 5.9 | 5.9 | 6.2 | pKd | 2 |
| Homo sapiens | Activin receptor type-1B | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Adaptor-associated kinase | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | ALK tyrosine kinase receptor | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | AMP-activated protein kinase, alpha-1 subunit | 5.6 | 5.6 | 7.1 | pKd | 2 |
| Homo sapiens | AMP-activated protein kinase, alpha-2 subunit | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | BMP-2-inducible protein kinase | 5.6 | 5.6 | 8.7 | pKd | 2 |
| Homo sapiens | Bone morphogenetic protein receptor type-2 | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Breakpoint cluster region protein | 6.5 | 6.5 | 6.5 | pKd | 2 |
| Plasmodium falciparum | Calcium-dependent protein kinase 1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | CaM kinase I alpha | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | CaM kinase I delta | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | CaM kinase I gamma | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | CaM kinase II alpha | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | CaM kinase IV | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | CaM-kinase kinase alpha | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | CaM-kinase kinase beta | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Casein kinase I delta | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Casein kinase I epsilon | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Casein kinase II alpha | 5.1 | 5.1 | 5.1 | pKd | 1 |
| Homo sapiens | Casein kinase II alpha (prime) | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | cGMP-dependent protein kinase 1 beta | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | c-Jun N-terminal kinase 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | c-Jun N-terminal kinase 3 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 3 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase 4 | 6.1 | 6.1 | 6.8 | pKd | 2 |
| Homo sapiens | Cyclin-dependent kinase 7 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Cyclin-dependent kinase-like 2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Death-associated protein kinase 2 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Death-associated protein kinase 3 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Discoidin domain-containing receptor 2 | 7.4 | 7.4 | 7.8 | pKd | 2 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | 8 | 8 | 8 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 2 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 3 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 4 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 5 | 6.8 | 6.8 | 8.7 | pKd | 2 |
| Homo sapiens | Dual specificity protein kinase CLK2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase CLK4 | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Dual specificity protein kinase TTK | 7.7 | 7.7 | 7.7 | pKd | 1 |
| Homo sapiens | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Dual specificty protein kinase CLK1 | 8.1 | 8.1 | 8.1 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 2 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 3 | 5.1 | 5.1 | 5.1 | pKd | 1 |
| Homo sapiens | Ephrin type-A receptor 6 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 1 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 4 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Ephrin type-B receptor 6 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Epithelial discoidin domain-containing receptor 1 | 7.7 | 7.7 | 7.9 | pKd | 2 |
| Homo sapiens | Eukaryotic translation initiation factor 2-alpha kinase 4 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 1 | 7.2 | 7 | 7.4 | pIC50 | 7 |
| Homo sapiens | Fibroblast growth factor receptor 1 | 5.7 | 5.7 | 7 | pKd | 2 |
| Homo sapiens | Fibroblast growth factor receptor 2 | 7.4 | 7.4 | 7.4 | pIC50 | 1 |
| Homo sapiens | Fibroblast growth factor receptor 2 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Fibroblast growth factor receptor 3 | 7 | 7 | 7 | pIC50 | 1 |
| Homo sapiens | Fibroblast growth factor receptor 3 | 6.9 | 6.9 | 7 | pKd | 2 |
| Homo sapiens | Fibroblast growth factor receptor 4 | 6.2 | 6.2 | 6.2 | pIC50 | 1 |
| Homo sapiens | Fibroblast growth factor receptor 4 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Focal adhesion kinase 1 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Glycogen synthase kinase-3 alpha | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Glycogen synthase kinase-3 beta | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | G protein-coupled receptor kinase 4 | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | G protein-coupled receptor kinase 7 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Hepatocyte growth factor receptor | 6.5 | 6.3 | 6.7 | pKd | 3 |
| Homo sapiens | Homeodomain-interacting protein kinase 1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 3 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Homeodomain-interacting protein kinase 4 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Inhibitor of nuclear factor kappa B kinase alpha subunit | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Inhibitor of nuclear factor kappa B kinase epsilon subunit | 6.8 | 6.8 | 6.8 | pKd | 2 |
| Homo sapiens | Insulin-like growth factor I receptor | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Insulin receptor | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Insulin receptor-related protein | 7.7 | 7.7 | 7.7 | pKd | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 1 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 3 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Interleukin-1 receptor-associated kinase 4 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Leucine-rich repeat serine/threonine-protein kinase 2 | 7.3 | 7.3 | 7.4 | pKd | 2 |
| Homo sapiens | Leukocyte tyrosine kinase receptor | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | Macrophage colony stimulating factor receptor | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | MAP/microtubule affinity-regulating kinase 2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | MAP/microtubule affinity-regulating kinase 4 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Maternal embryonic leucine zipper kinase | 7.4 | 7.4 | 7.4 | pIC50 | 1 |
| Homo sapiens | Maternal embryonic leucine zipper kinase | 7.3 | 7.3 | 8.3 | pKd | 2 |
| Homo sapiens | Maternal embryonic leucine zipper kinase | 8.3 | 8.3 | 8.3 | pKi | 1 |
| Homo sapiens | Microtubule-associated serine/threonine-protein kinase 1 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Misshapen-like kinase 1 | 5.6 | 5.6 | 7.1 | pKd | 2 |
| Homo sapiens | Mitogen-activated protein kinase 7 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 10 | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 11 | 6.2 | 6.2 | 6.2 | pKd | 2 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 12 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 13 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 15 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 2 | 5.8 | 5.8 | 8 | pKd | 2 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 3 | 5.3 | 5.3 | 7.5 | pKd | 2 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 7 | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase 9 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 1 | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 2 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 3 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 4 | 5.9 | 5.9 | 6.8 | pKd | 2 |
| Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 5 | 5.5 | 5.5 | 6.4 | pKd | 2 |
| Homo sapiens | Muscle, skeletal receptor tyrosine protein kinase | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Myosin-IIIB | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Myosin light chain kinase | 5 | 5 | 7 | pKd | 2 |
| Homo sapiens | myosin light chain kinase 2 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Myosin light chain kinase family member 4 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Myosin light chain kinase, smooth muscle | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Nerve growth factor receptor Trk-A | 5.5 | 5.5 | 8.4 | pKd | 2 |
| Homo sapiens | Neurotrophic tyrosine kinase receptor type 2 | 7.7 | 7.7 | 7.7 | pKd | 1 |
| Homo sapiens | Non-receptor tyrosine-protein kinase TNK1 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | NT-3 growth factor receptor | 7.5 | 7.5 | 7.5 | pKd | 1 |
| Homo sapiens | NUAK family SNF1-like kinase 1 | 6.8 | 6.8 | 6.8 | pKd | 1 |
| Homo sapiens | NUAK family SNF1-like kinase 2 | 7.7 | 7.7 | 7.7 | pKd | 1 |
| Homo sapiens | Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Phosphatidylinositol-5-phosphate 4-kinase type-2 beta | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Phosphorylase kinase gamma subunit 1 | 6.9 | 6.9 | 6.9 | pKd | 1 |
| Homo sapiens | Phosphorylase kinase gamma subunit 2 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor alpha | 8.4 | 7.2 | 8.7 | pIC50 | 5 |
| Homo sapiens | Platelet-derived growth factor receptor alpha | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Platelet-derived growth factor receptor beta | 8.4 | 7.2 | 8.7 | pIC50 | 6 |
| Homo sapiens | Platelet-derived growth factor receptor beta | 7.5 | 7.5 | 7.8 | pKd | 2 |
| Homo sapiens | Protein kinase C mu | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Protein kinase C nu | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Protein kinase C theta | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Protein kinase N1 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Protein kinase N2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Protein tyrosine kinase 2 beta | 7.1 | 7.1 | 7.1 | pKd | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase MER | 8.1 | 8.1 | 8.1 | pKd | 1 |
| Homo sapiens | Proto-oncogene tyrosine-protein kinase ROS | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Putative uncharacterized serine/threonine-protein kinase SgK110 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Receptor-interacting serine/threonine-protein kinase 1 | 6.6 | 6.6 | 6.6 | pKd | 1 |
| Homo sapiens | Receptor-interacting serine/threonine-protein kinase 4 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Rhodopsin kinase | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Ribosomal protein S6 kinase 1 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 1 | 5.7 | 5.7 | 6.8 | pKd | 4 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 2 | 7.2 | 7.2 | 7.2 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 3 | 7.2 | 7.2 | 7.2 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 4 | 6.2 | 6.2 | 6.2 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 5 | 6.7 | 6.7 | 6.7 | pKd | 2 |
| Homo sapiens | Ribosomal protein S6 kinase alpha 6 | 6.6 | 6.6 | 6.6 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase 10 | 6.1 | 6.1 | 7.1 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase 11 | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 16 | 7.8 | 7.8 | 7.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 17A | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 17B | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 2 | 5.4 | 5.4 | 7.3 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase 24 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 33 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase 35 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-B | 6 | 6 | 6.4 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase Aurora-C | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Chk1 | 5.4 | 5.4 | 6.5 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase c-TAK1 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase D2 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase DCLK1 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase DCLK3 | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase/endoribonuclease IRE1 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase ICK | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase LATS1 | 5 | 5 | 6.4 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase LATS2 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MARK1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase MST1 | 6.8 | 6.8 | 8.1 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase MST2 | 6.1 | 6.1 | 7.4 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase MST4 | 5.6 | 5.6 | 7.3 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase OSR1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 2 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 3 | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK 4 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PAK7 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-1 | 7.7 | 7.7 | 7.7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-2 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PCTAIRE-3 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PFTAIRE-1 | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Mycobacterium tuberculosis | Serine/threonine-protein kinase pknB | 8.4 | 8.4 | 8.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PLK4 | 7.3 | 7.3 | 7.3 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase PRP4 homolog | 8.1 | 8.1 | 8.1 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase receptor R3 | 5.4 | 5.4 | 5.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RIO1 | 7.6 | 7.6 | 7.6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase RIO3 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SBK1 | 7 | 7 | 7 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase Sgk3 | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SIK2 | 6.6 | 6.6 | 6.9 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase SRPK1 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SRPK2 | 7.4 | 7.4 | 7.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase SRPK3 | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase TBK1 | 5.3 | 5.3 | 6.8 | pKd | 2 |
| Homo sapiens | Serine/threonine-protein kinase ULK1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase ULK2 | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase ULK3 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Serine/threonine-protein kinase WEE1 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | SPS1/STE20-related protein kinase YSK4 | 8.3 | 8.3 | 8.3 | pKd | 1 |
| Homo sapiens | STE20/SPS1-related proline-alanine-rich protein kinase | 6.3 | 6.3 | 6.3 | pKd | 1 |
| Homo sapiens | Stem cell growth factor receptor | 7.5 | 6.5 | 8.6 | pKd | 8 |
| Homo sapiens | Testis-specific serine/threonine-protein kinase 1 | 5.2 | 5.2 | 5.2 | pKd | 1 |
| Homo sapiens | TGF-beta receptor type I | 5.4 | 5.4 | 5.7 | pKd | 2 |
| Homo sapiens | TRAF2- and NCK-interacting kinase | 6 | 6 | 7.3 | pKd | 2 |
| Homo sapiens | Tyrosine kinase non-receptor protein 2 | 5.8 | 5.8 | 5.8 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase ABL | 7.2 | 5.2 | 8 | pKd | 16 |
| Homo sapiens | Tyrosine-protein kinase ABL2 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BLK | 6.4 | 6.4 | 6.4 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase BTK | 5.5 | 5.5 | 6.5 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase FER | 5.3 | 5.3 | 7.1 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase FES | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FGR | 6.5 | 6.5 | 6.5 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FRK | 5.6 | 5.6 | 5.6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase FYN | 5.8 | 5.8 | 6.2 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase HCK | 5.3 | 5.3 | 5.8 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase ITK/TSK | 6.7 | 6.7 | 6.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase JAK1 | 5.6 | 5.6 | 8.3 | pKd | 4 |
| Homo sapiens | Tyrosine-protein kinase JAK2 | 7 | 7 | 7.9 | pKd | 4 |
| Homo sapiens | Tyrosine-protein kinase JAK3 | 8.1 | 8.1 | 8.1 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase LCK | 7.8 | 7.8 | 7.8 | pIC50 | 2 |
| Homo sapiens | Tyrosine-protein kinase LCK | 7.2 | 7.2 | 8.2 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase Lyn | 6.7 | 6.7 | 7.3 | pIC50 | 3 |
| Homo sapiens | Tyrosine-protein kinase Lyn | 6 | 6 | 6 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 7.6 | 7.6 | 7.6 | pIC50 | 2 |
| Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 8.4 | 7.8 | 9.4 | pKd | 9 |
| Homo sapiens | Tyrosine-protein kinase receptor RET | 8 | 7.5 | 8.5 | pKd | 5 |
| Homo sapiens | Tyrosine-protein kinase receptor Tie-1 | 5.7 | 5.7 | 5.7 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor TYRO3 | 5.3 | 5.3 | 5.3 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase receptor UFO | 7.9 | 7.9 | 7.9 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase SRC | 6.8 | 6.8 | 7.8 | pIC50 | 3 |
| Homo sapiens | Tyrosine-protein kinase SRC | 6.2 | 6.2 | 6.2 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TIE-2 | 5.9 | 5.9 | 5.9 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TXK | 6.1 | 6.1 | 6.1 | pKd | 1 |
| Homo sapiens | Tyrosine-protein kinase TYK2 | 6.3 | 6.3 | 7.4 | pKd | 4 |
| Homo sapiens | Tyrosine-protein kinase YES | 6 | 6 | 7.1 | pKd | 2 |
| Homo sapiens | Tyrosine-protein kinase ZAP-70 | 5.5 | 5.5 | 5.5 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | 7.6 | 7 | 7.9 | pIC50 | 5 |
| Homo sapiens | Vascular endothelial growth factor receptor 1 | 7.2 | 7.2 | 7.2 | pKd | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 8.1 | 7.7 | 8.5 | pIC50 | 8 |
| Homo sapiens | Vascular endothelial growth factor receptor 2 | 8.5 | 8.5 | 8.5 | pKd | 1 |
| Mus musculus | Vascular endothelial growth factor receptor 2 | 7.9 | 7.9 | 7.9 | pIC50 | 1 |
| Homo sapiens | Vascular endothelial growth factor receptor 3 | 8.3 | 7.5 | 8.5 | pIC50 | 5 |
| Homo sapiens | Vascular endothelial growth factor receptor 3 | 7 | 7 | 7 | pKd | 1 |