4OTH - chain A (model A) | Protein kinase N1
Structure information
PDB:4OTH
PubMed:25111382
Release date:2014-08-27
Resolution:1.8 Å
 
Kinase:PKN1
Family:PKN
Group:AGC
Species:HUMAN
 
Quality Score:8
Missing Residues:0
Missing Atoms:0
DFG conformation:in
αC-helix conformation:out
Salt bridge KIII.17 and EαC.24:Yes (3Å)
 
 
ASP rotation (xDFG.81) :337°
PHE rotation (xDFG.82) :306°
Activation loop position:-5Å
αC-helix position:20.2Å
 
G-rich loop angle:56.3°
G-rich loop distance:16.7Å
G-rich loop rotation:44.6°
Other models from this PDB:
2D & 3D views

The orthosteric binding pocket
Binding pocket waters
The following waters were found in the defined clusters:
I4
H-bond protein
I5
H-bond protein
Binding pocket sequence
UniprotAVLGRGHFGKVLLFAIKALSLMCEKRILAAVTPFLVNLFGCCFVMEYSAGGDLMLHIHSFLHEHKIVYRDLKLDNLLLIADFGLC
Structure:AVLGRGHFGKVLLFAIKALSLMCEKRILAAVTPFLVNLFGCCFVMEYSAGGDLMLHIHSFLHEHKIVYRDLKLDNLLLIADFGLC


Modified residues
Residue 922 (not in pocket)
Phosphorylated serine