5VCV - chain A | Protein kinase, membrane associated tyrosine/threonine 1
Structure information
PDB: | 5VCV |
PubMed: | 28792760 |
Release date: | 2017-08-23 |
Resolution: | 1.92 Å |
Kinase: | PKMYT1 (MYT1) |
Family: | WEE |
Group: | Other |
Species: | HUMAN |
Quality Score: | 8 |
Missing Residues: | 0 |
Missing Atoms: | 0 |
DFG conformation: | in |
αC-helix conformation: | in |
Salt bridge KIII.17 and EαC.24: | Yes (2.8Å) |
ASP rotation (xDFG.81) : | 343° |
PHE rotation (xDFG.82) : | 359° |
Activation loop position: | -3.3Å |
αC-helix position: | 18.2Å |
G-rich loop angle: | 59.9° |
G-rich loop distance: | 18.6Å |
G-rich loop rotation: | 54.6° |
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I2
H-bond protein
I3
H-bond protein
I4
H-bond protein
Binding pocket sequence
Uniprot | SRLGHGSYGEVFKYAVKRSRKLAEVGSHEKVGPCCVRLEQAYLQTELC-GPSLQQHCEAHLHSQGLVHLDVKPANIFLLGDFGLL |
Structure: | SRLGHGSYGEVFKYAVKRSRKLAEVGSHEKVGPCCVRLEQAYLQTELC_GPSLQQHCEAHLHSQGLVHLDVKPANIFLLGDFGLL |
Modified residues
Residue 260 (not in pocket)
Phosphorylated threonine
Orthosteric ligand
Ligand HET-code: 1N1
Ligand Name: N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE
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- LABELS
- KLIFS residue #
- Amino Acid
- None
- COLORS
- Interaction types
- KLIFS (all res.)
- KLIFS (interacting res.)
- None
- OTHER
- Show/hide non-interacting res.
- En/disable resizing interacting res.
This ligand targets the following (sub)pockets:
Main pockets | |
---|---|
Front | |
Gate | |
Back |
Subpockets | |
---|---|
FP-I | |
FP-II | |
BP-I-A | |
BP-I-B | |
BP-II-in | |
BP-II-A-in | |
BP-II-B-in | |
BP-II-out | |
BP-II-B | |
BP-III | |
BP-IV | |
BP-V |
Kinase-ligand interactions
■ Hydrophobic ♦ Aromatic face-to-face ♦ Aromatic face-to-edge ▲ H-bond donor ▲ H-bond acceptor ● Ionic positive ● Ionic negative
I | g.l | II | III | αC | |||||||||||||||
1 S 114 | 2 R 115 | 3 L 116 | 4 G 117 | 5 H 118 | 6 G 119 | 7 S 120 | 8 Y 121 | 9 G 122 | 10 E 123 | 11 V 124 | 12 F 125 | 13 K 126 | 14 Y 136 | 15 A 137 | 16 V 138 | 17 K 139 | 18 R 140 | 19 S 141 | 20 R 153 |
■ | ■ | ■ | ■ | ■ | |||||||||||||||
αC | b.l | IV | |||||||||||||||||
21 K 154 | 22 L 155 | 23 A 156 | 24 E 157 | 25 V 158 | 26 G 159 | 27 S 160 | 28 H 161 | 29 E 162 | 30 K 163 | 31 V 164 | 32 G 165 | 33 P 168 | 34 C 169 | 35 C 170 | 36 V 171 | 37 R 172 | 38 L 173 | 39 E 174 | 40 Q 175 |
■ | ■ | ||||||||||||||||||
IV | V | GK | hinge | linker | αD | αE | |||||||||||||
41 A 176 | 42 Y 184 | 43 L 185 | 44 Q 186 | 45 T 187 | 46 E 188 | 47 L 189 | 48 C 190 | 49 _ _ | 50 G 191 | 51 P 192 | 52 S 193 | 53 L 194 | 54 Q 195 | 55 Q 196 | 56 H 197 | 57 C 198 | 58 E 199 | 59 A 200 | 60 H 223 |
■ | ■▲ | ■ | ■▲▲ | ■ | ■ | ■▲ | |||||||||||||
αE | VI | c.l | VII | VIII | x | ||||||||||||||
61 L 224 | 62 H 225 | 63 S 226 | 64 Q 227 | 65 G 228 | 66 L 229 | 67 V 230 | 68 H 231 | 69 L 232 | 70 D 233 | 71 V 234 | 72 K 235 | 73 P 236 | 74 A 237 | 75 N 238 | 76 I 239 | 77 F 240 | 78 L 241 | 79 L 249 | 80 G 250 |
■♦ | ■ | ||||||||||||||||||
DFG | a.l | ||||||||||||||||||
81 D 251 | 82 F 252 | 83 G 253 | 84 L 254 | 85 L 255 | |||||||||||||||
■ |
Binding affinities
ChEMBL ID:CHEMBL1421Bioaffinities: 493 records for 144 kinase(s)
Species | Kinase (ChEMBL naming) | Median | Min | Max | Type | Records |
---|---|---|---|---|---|---|
Homo sapiens | Activin receptor type-1 | 6.2 | 6.2 | 6.2 | pKd | 2 |
Homo sapiens | Activin receptor type-1 | 7.1 | 7.1 | 7.1 | pKi | 1 |
Homo sapiens | Activin receptor type-1B | 6.5 | 5.9 | 6.5 | pKd | 3 |
Homo sapiens | Activin receptor type-2A | 6.7 | 6.7 | 6.7 | pKd | 2 |
Homo sapiens | Activin receptor type-2B | 6.2 | 5.6 | 6.2 | pKd | 3 |
Homo sapiens | Bone morphogenetic protein receptor type-1A | 5.2 | 5.2 | 5.2 | pKd | 1 |
Homo sapiens | Bone morphogenetic protein receptor type-1B | 7.3 | 7.3 | 7.3 | pKd | 1 |
Homo sapiens | Breakpoint cluster region protein | 8.3 | 8.3 | 8.3 | pKd | 2 |
Plasmodium falciparum | Calcium-dependent protein kinase 1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
Homo sapiens | cAMP-dependent protein kinase beta-1 catalytic subunit | 5.9 | 5.9 | 5.9 | pKd | 1 |
Homo sapiens | Casein kinase I epsilon | 5.8 | 5.6 | 5.8 | pKd | 3 |
Homo sapiens | Chaperone activity of bc1 complex-like, mitochondrial | 6.7 | 6.7 | 6.7 | pKd | 2 |
Homo sapiens | Discoidin domain-containing receptor 2 | 8.7 | 6.1 | 9.4 | pIC50 | 6 |
Homo sapiens | Discoidin domain-containing receptor 2 | 8.5 | 7.2 | 8.5 | pKd | 5 |
Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | 6 | 6 | 6 | pKd | 2 |
Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 1 | 6.2 | 6.2 | 6.2 | pKi | 1 |
Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 2 | 5.9 | 5.5 | 5.9 | pKd | 3 |
Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 2 | 5.8 | 5.8 | 5.8 | pKi | 1 |
Homo sapiens | Dual specificity mitogen-activated protein kinase kinase 5 | 5.8 | 5.8 | 8.5 | pKd | 2 |
Homo sapiens | Dual specificity testis-specific protein kinase 1 | 7.5 | 7.2 | 7.5 | pKd | 3 |
Homo sapiens | Dual-specificity tyrosine-phosphorylation regulated kinase 3 | 5.9 | 5.9 | 5.9 | pKi | 1 |
Homo sapiens | Ephrin type-A receptor 1 | 8.4 | 7.8 | 8.4 | pKd | 3 |
Homo sapiens | Ephrin type-A receptor 2 | 6.9 | 6.9 | 6.9 | pIC50 | 1 |
Homo sapiens | Ephrin type-A receptor 2 | 9.1 | 8.2 | 9.1 | pKd | 3 |
Homo sapiens | Ephrin type-A receptor 2 | 8.4 | 8.4 | 8.4 | pKi | 1 |
Homo sapiens | Ephrin type-A receptor 3 | 10 | 10 | 10 | pKd | 2 |
Homo sapiens | Ephrin type-A receptor 4 | 8.9 | 8.2 | 8.9 | pKd | 3 |
Homo sapiens | Ephrin type-A receptor 5 | 9.6 | 8.4 | 9.6 | pKd | 3 |
Homo sapiens | Ephrin type-A receptor 6 | 5.7 | 5.7 | 5.7 | pKd | 1 |
Homo sapiens | Ephrin type-A receptor 8 | 9.6 | 9.6 | 9.6 | pKd | 2 |
Homo sapiens | Ephrin type-B receptor 1 | 9.4 | 9.4 | 9.4 | pKd | 2 |
Homo sapiens | Ephrin type-B receptor 2 | 8.4 | 8.4 | 8.4 | pIC50 | 1 |
Homo sapiens | Ephrin type-B receptor 2 | 9.4 | 8.4 | 9.4 | pKd | 3 |
Homo sapiens | Ephrin type-B receptor 3 | 8.2 | 7.5 | 8.2 | pKd | 3 |
Homo sapiens | Ephrin type-B receptor 4 | 9.5 | 8.4 | 9.5 | pKd | 3 |
Homo sapiens | Ephrin type-B receptor 6 | 7.5 | 7.5 | 10.4 | pKd | 2 |
Homo sapiens | Epidermal growth factor receptor erbB1 | 6.8 | 5.5 | 7.7 | pIC50 | 5 |
Homo sapiens | Epidermal growth factor receptor erbB1 | 6.9 | 5.6 | 7.1 | pKd | 23 |
Homo sapiens | Epithelial discoidin domain-containing receptor 1 | 8.3 | 8.3 | 9.3 | pIC50 | 2 |
Homo sapiens | Epithelial discoidin domain-containing receptor 1 | 9.2 | 7.4 | 9.2 | pKd | 3 |
Homo sapiens | Eukaryotic translation initiation factor 2-alpha kinase 4 | 5.8 | 5.8 | 5.8 | pKd | 2 |
Homo sapiens | Fibroblast growth factor receptor 1 | 6.1 | 6.1 | 6.1 | pIC50 | 1 |
Homo sapiens | Fibroblast growth factor receptor 1 | 5.4 | 5.4 | 5.4 | pKd | 2 |
Homo sapiens | Fibroblast growth factor receptor 1 | 5.7 | 5.7 | 5.7 | pKi | 1 |
Homo sapiens | Fibroblast growth factor receptor 2 | 5.9 | 5.9 | 5.9 | pKd | 2 |
Homo sapiens | Fibroblast growth factor receptor 3 | 5.4 | 5.4 | 5.4 | pKd | 1 |
Homo sapiens | Fibroblast growth factor receptor 3 | 5.9 | 5.9 | 5.9 | pKi | 1 |
Homo sapiens | Interleukin-1 receptor-associated kinase 4 | 5.3 | 5.3 | 5.3 | pKi | 1 |
Homo sapiens | LIM domain kinase 1 | 6.9 | 6.9 | 6.9 | pIC50 | 1 |
Homo sapiens | LIM domain kinase 1 | 6.2 | 6 | 6.2 | pKd | 3 |
Homo sapiens | LIM domain kinase 1 | 6.6 | 6.6 | 6.6 | pKi | 1 |
Homo sapiens | LIM domain kinase 2 | 7.1 | 6 | 7.1 | pKd | 3 |
Homo sapiens | Macrophage colony stimulating factor receptor | 8.1 | 8.1 | 8.3 | pIC50 | 2 |
Homo sapiens | Macrophage colony stimulating factor receptor | 9.2 | 9.2 | 9.2 | pKd | 2 |
Homo sapiens | MAP kinase-activated protein kinase 2 | 6.3 | 6.3 | 6.3 | pKd | 1 |
Homo sapiens | MAP kinase p38 alpha | 6.3 | 6.3 | 6.3 | pEC50 | 1 |
Homo sapiens | MAP kinase p38 alpha | 6.3 | 6 | 7.6 | pKd | 6 |
Homo sapiens | MAP kinase p38 alpha | 7.5 | 7.5 | 7.5 | pKi | 1 |
Homo sapiens | MAP kinase p38 beta | 6.4 | 6.4 | 6.4 | pKd | 2 |
Homo sapiens | Misshapen-like kinase 1 | 6.4 | 6.4 | 6.7 | pKd | 2 |
Homo sapiens | Misshapen-like kinase 1 | 6.1 | 6.1 | 6.1 | pKi | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 10 | 5.6 | 5.6 | 5.6 | pKi | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 13 | 5.3 | 5.3 | 5.3 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 2 | 5.7 | 5.7 | 6.9 | pKd | 2 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 3 | 6.6 | 6.6 | 6.6 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 4 | 6.5 | 6.5 | 6.5 | pKd | 2 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase 7 | 5.4 | 5.4 | 5.4 | pKd | 1 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 1 | 6 | 5.7 | 6 | pKd | 3 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 2 | 5.8 | 5.8 | 5.9 | pKd | 2 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 3 | 6.2 | 5.7 | 6.2 | pKd | 3 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 4 | 5.5 | 5.4 | 5.5 | pKd | 3 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 5 | 7.4 | 6 | 7.4 | pKd | 3 |
Homo sapiens | Mitogen-activated protein kinase kinase kinase kinase 5 | 7.8 | 7.8 | 7.8 | pKi | 1 |
Homo sapiens | Mixed lineage kinase 7 | 7.4 | 6.7 | 7.4 | pKd | 3 |
Homo sapiens | Mixed lineage kinase 7 | 7.3 | 7.3 | 7.3 | pKi | 1 |
Homo sapiens | myosin light chain kinase 2 | 5.5 | 5.5 | 5.5 | pKd | 1 |
Homo sapiens | Myosin light chain kinase, smooth muscle | 7.1 | 7.1 | 7.1 | pKd | 1 |
Homo sapiens | Myotonin-protein kinase | 5.9 | 5.9 | 5.9 | pKd | 2 |
Homo sapiens | Non-receptor tyrosine-protein kinase TNK1 | 6.2 | 6.2 | 6.2 | pKd | 1 |
Homo sapiens | PI3-kinase p110-alpha subunit | 4.4 | 4.4 | 4.4 | pIC50 | 1 |
Homo sapiens | PI3-kinase p110-delta subunit | 4.5 | 4.5 | 4.5 | pIC50 | 1 |
Homo sapiens | Platelet-derived growth factor receptor alpha | 7.2 | 7.2 | 8 | pIC50 | 2 |
Homo sapiens | Platelet-derived growth factor receptor alpha | 9.3 | 9.3 | 9.3 | pKd | 2 |
Homo sapiens | Platelet-derived growth factor receptor alpha | 8 | 8 | 8 | pKi | 1 |
Homo sapiens | Platelet-derived growth factor receptor beta | 7.6 | 7.6 | 7.6 | pIC50 | 1 |
Homo sapiens | Platelet-derived growth factor receptor beta | 9.2 | 6.5 | 9.2 | pKd | 3 |
Homo sapiens | Platelet-derived growth factor receptor beta | 8.9 | 8.9 | 8.9 | pKi | 1 |
Homo sapiens | Protein kinase C theta | 6.2 | 6.2 | 6.2 | pKd | 1 |
Homo sapiens | Protein kinase N1 | 6.5 | 6.5 | 6.5 | pKd | 1 |
Homo sapiens | Protein kinase N2 | 5.3 | 5.3 | 5.3 | pKi | 1 |
Homo sapiens | Receptor protein-tyrosine kinase erbB-2 | 6.2 | 6.2 | 6.2 | pIC50 | 2 |
Homo sapiens | Receptor protein-tyrosine kinase erbB-2 | 5.9 | 5.9 | 5.9 | pKd | 2 |
Homo sapiens | Receptor protein-tyrosine kinase erbB-2 | 6.8 | 6.8 | 6.8 | pKi | 1 |
Homo sapiens | Receptor protein-tyrosine kinase erbB-4 | 7.3 | 7.3 | 7.3 | pKd | 1 |
Homo sapiens | Receptor protein-tyrosine kinase erbB-4 | 7.4 | 7.4 | 7.4 | pKi | 1 |
Homo sapiens | Receptor tyrosine-protein kinase erbB-3 | 7.8 | 7.8 | 7.8 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase 10 | 5.9 | 5.6 | 5.9 | pKd | 3 |
Homo sapiens | Serine/threonine-protein kinase 2 | 6.1 | 5.7 | 6.1 | pKd | 3 |
Homo sapiens | Serine/threonine-protein kinase 2 | 6.2 | 6.2 | 6.2 | pKi | 1 |
Homo sapiens | Serine/threonine-protein kinase 25 | 5.5 | 5.5 | 5.5 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase 35 | 6.1 | 6.1 | 6.1 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase 36 | 6.7 | 6.7 | 6.7 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase Aurora-A | 5.6 | 5.6 | 5.6 | pIC50 | 1 |
Homo sapiens | Serine/threonine-protein kinase Aurora-A | 5 | 5 | 5 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase Aurora-B | 5.2 | 5.2 | 5.2 | pIC50 | 1 |
Homo sapiens | Serine/threonine-protein kinase Aurora-B | 5.9 | 5.9 | 5.9 | pKi | 1 |
Homo sapiens | Serine/threonine-protein kinase B-raf | 6.2 | 5.5 | 6.3 | pKd | 5 |
Homo sapiens | Serine/threonine-protein kinase GAK | 8.6 | 6.8 | 8.6 | pKd | 4 |
Homo sapiens | Serine/threonine-protein kinase MRCK-A | 5.7 | 5.7 | 5.7 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase MRCK-A | 5.2 | 5.2 | 5.2 | pKi | 1 |
Homo sapiens | Serine/threonine-protein kinase MRCK beta | 5.7 | 5.7 | 5.7 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase MRCK gamma | 5.9 | 5.9 | 5.9 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase MST1 | 5.4 | 5.4 | 5.4 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase MST4 | 5.7 | 5.7 | 5.7 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase mTOR | 4.5 | 4.5 | 4.5 | pIC50 | 1 |
Homo sapiens | Serine/threonine-protein kinase Nek11 | 6.3 | 6.3 | 6.3 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase NEK2 | 5.2 | 5.2 | 5.2 | pKd | 1 |
Homo sapiens | Serine/threonine protein kinase NLK | 6.6 | 6.6 | 6.6 | pKd | 3 |
Homo sapiens | Serine/threonine-protein kinase PAK 4 | 6.1 | 6.1 | 6.1 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase PLK4 | 5.7 | 5.7 | 5.7 | pKi | 1 |
Homo sapiens | Serine/threonine-protein kinase RAF | 6.8 | 6.8 | 6.8 | pIC50 | 1 |
Homo sapiens | Serine/threonine-protein kinase RAF | 6.2 | 6.2 | 6.2 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase receptor R3 | 6.3 | 6.3 | 6.3 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase RIPK2 | 7 | 7 | 7 | pIC50 | 1 |
Homo sapiens | Serine/threonine-protein kinase RIPK2 | 7.5 | 7.5 | 7.7 | pKd | 3 |
Homo sapiens | Serine/threonine-protein kinase SBK1 | 5.9 | 5.9 | 5.9 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase SIK1 | 8.4 | 8.4 | 8.4 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase SIK2 | 8.2 | 7.6 | 8.2 | pKd | 3 |
Homo sapiens | Serine/threonine-protein kinase SIK2 | 9.1 | 9.1 | 9.1 | pKi | 1 |
Homo sapiens | Serine/threonine-protein kinase SIK3 | 6.8 | 6.8 | 7.6 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase TAO1 | 6 | 6 | 6 | pKi | 1 |
Homo sapiens | Serine/threonine-protein kinase TAO2 | 5.3 | 5.3 | 5.3 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase TAO3 | 5.6 | 5.6 | 5.6 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase TNNI3K | 8 | 8 | 8 | pKd | 2 |
Homo sapiens | Serine/threonine-protein kinase ULK3 | 5.3 | 5.3 | 5.3 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase VRK2 | 5.5 | 5.5 | 5.5 | pKd | 1 |
Homo sapiens | Serine/threonine-protein kinase WEE1 | 5.2 | 5.2 | 5.3 | pKd | 4 |
Homo sapiens | SPS1/STE20-related protein kinase YSK4 | 7.1 | 7.1 | 7.1 | pKd | 1 |
Homo sapiens | Stem cell growth factor receptor | 8.3 | 6.9 | 8.8 | pIC50 | 9 |
Homo sapiens | Stem cell growth factor receptor | 8.8 | 7.2 | 9.2 | pKd | 14 |
Homo sapiens | TGF-beta receptor type I | 6.6 | 5.8 | 6.6 | pKd | 3 |
Homo sapiens | TGF-beta receptor type II | 5.5 | 5.5 | 5.5 | pKd | 3 |
Homo sapiens | TRAF2- and NCK-interacting kinase | 5.7 | 5.7 | 5.9 | pKd | 3 |
Homo sapiens | Tyrosine- and threonine-specific cdc2-inhibitory kinase | 6.7 | 6.7 | 8.2 | pIC50 | 2 |
Homo sapiens | Tyrosine- and threonine-specific cdc2-inhibitory kinase | 6.8 | 5.9 | 6.9 | pKd | 4 |
Homo sapiens | Tyrosine- and threonine-specific cdc2-inhibitory kinase | 7.1 | 7.1 | 9.3 | pKi | 2 |
Homo sapiens | Tyrosine kinase non-receptor protein 2 | 8.2 | 7.6 | 8.3 | pKd | 4 |
Homo sapiens | Tyrosine kinase non-receptor protein 2 | 8.6 | 8.6 | 8.6 | pKi | 1 |
Homo sapiens | Tyrosine-protein kinase ABL | 8.5 | 5.8 | 9.8 | pIC50 | 15 |
Homo sapiens | Tyrosine-protein kinase ABL | 10.2 | 6.1 | 10.8 | pKd | 23 |
Homo sapiens | Tyrosine-protein kinase ABL | 9.3 | 9.3 | 9.3 | pKi | 1 |
Homo sapiens | Tyrosine-protein kinase ABL2 | 9.8 | 8.4 | 9.8 | pKd | 3 |
Homo sapiens | Tyrosine-protein kinase BLK | 9.7 | 9.7 | 9.7 | pKd | 2 |
Mus musculus | Tyrosine-protein kinase BLK | 8.1 | 8.1 | 8.1 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase BMX | 8.9 | 8.9 | 8.9 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase BRK | 8.1 | 8.1 | 8.3 | pIC50 | 2 |
Homo sapiens | Tyrosine-protein kinase BRK | 8.1 | 7.2 | 8.1 | pKd | 3 |
Homo sapiens | Tyrosine-protein kinase BRK | 8.3 | 8.3 | 8.3 | pKi | 1 |
Homo sapiens | Tyrosine-protein kinase BTK | 8.3 | 8.3 | 8.9 | pIC50 | 4 |
Homo sapiens | Tyrosine-protein kinase BTK | 8.9 | 8.3 | 8.9 | pKd | 3 |
Homo sapiens | Tyrosine-protein kinase CSK | 8.9 | 8.9 | 8.9 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase CSK | 9 | 7.7 | 9 | pKd | 3 |
Homo sapiens | Tyrosine-protein kinase FES | 5.7 | 5.7 | 5.7 | pKi | 1 |
Homo sapiens | Tyrosine-protein kinase FGR | 9.3 | 8.3 | 9.3 | pKd | 3 |
Homo sapiens | Tyrosine-protein kinase FRK | 9.5 | 8.3 | 9.5 | pKd | 4 |
Homo sapiens | Tyrosine-protein kinase FYN | 8.8 | 8.8 | 9.7 | pIC50 | 2 |
Homo sapiens | Tyrosine-protein kinase FYN | 9.1 | 8.4 | 9.1 | pKd | 3 |
Homo sapiens | Tyrosine-protein kinase HCK | 9.5 | 7.5 | 9.5 | pKd | 3 |
Homo sapiens | Tyrosine-protein kinase HCK | 9.5 | 9.5 | 9.5 | pKi | 1 |
Homo sapiens | Tyrosine-protein kinase ITK/TSK | 6.6 | 6.6 | 6.6 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase JAK2 | 6 | 6 | 6 | pKd | 4 |
Homo sapiens | Tyrosine-protein kinase JAK2 | 5.9 | 5.9 | 5.9 | pKi | 2 |
Homo sapiens | Tyrosine-protein kinase JAK3 | 6.2 | 6.2 | 6.2 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase LCK | 8.6 | 8.4 | 9.4 | pIC50 | 5 |
Homo sapiens | Tyrosine-protein kinase LCK | 9.7 | 8.2 | 9.7 | pKd | 3 |
Mus musculus | Tyrosine-protein kinase LCK | 10.2 | 10.2 | 10.2 | pKi | 1 |
Homo sapiens | Tyrosine-protein kinase Lyn | 8.9 | 8.9 | 8.9 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase Lyn | 9.2 | 8.1 | 9.2 | pKd | 3 |
Homo sapiens | Tyrosine-protein kinase receptor FLT3 | 5.2 | 5 | 5.5 | pKd | 7 |
Homo sapiens | Tyrosine-protein kinase receptor RET | 5.7 | 5.7 | 6.4 | pIC50 | 2 |
Homo sapiens | Tyrosine-protein kinase receptor RET | 6.1 | 5.5 | 6.4 | pKd | 6 |
Homo sapiens | Tyrosine-protein kinase receptor UFO | 5.7 | 5.7 | 5.7 | pKi | 1 |
Gallus gallus | Tyrosine-protein kinase SRC | 6.3 | 6.3 | 9.4 | pIC50 | 2 |
Gallus gallus | Tyrosine-protein kinase SRC | 8 | 8 | 8 | pKd | 1 |
Homo sapiens | Tyrosine-protein kinase SRC | 9.2 | 7.9 | 9.5 | pIC50 | 10 |
Homo sapiens | Tyrosine-protein kinase SRC | 9.7 | 8 | 9.7 | pKd | 5 |
Homo sapiens | Tyrosine-protein kinase SRC | 9.5 | 9.5 | 9.5 | pKi | 1 |
Homo sapiens | Tyrosine-protein kinase Srms | 7.9 | 7.9 | 7.9 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase Srms | 9.2 | 9.2 | 9.2 | pKi | 1 |
Homo sapiens | Tyrosine-protein kinase SYK | 5.5 | 5.5 | 5.6 | pKd | 3 |
Homo sapiens | Tyrosine-protein kinase SYK | 6.7 | 6.7 | 6.7 | pKi | 1 |
Homo sapiens | Tyrosine-protein kinase TEC | 6.5 | 6.5 | 6.5 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase TEC | 7.9 | 7.4 | 7.9 | pKd | 3 |
Homo sapiens | Tyrosine-protein kinase TXK | 9.5 | 9.5 | 9.5 | pIC50 | 1 |
Homo sapiens | Tyrosine-protein kinase TXK | 8.7 | 8.7 | 8.7 | pKd | 2 |
Homo sapiens | Tyrosine-protein kinase TYK2 | 5.9 | 5.8 | 7 | pKd | 6 |
Homo sapiens | Tyrosine-protein kinase YES | 9.3 | 9.3 | 9.3 | pIC50 | 3 |
Homo sapiens | Tyrosine-protein kinase YES | 9.5 | 8.4 | 9.5 | pKd | 3 |
Homo sapiens | Vascular endothelial growth factor receptor 1 | 5.3 | 5.3 | 5.3 | pKd | 2 |
Homo sapiens | Vascular endothelial growth factor receptor 2 | 5.6 | 5.6 | 5.6 | pIC50 | 1 |
Homo sapiens | Vascular endothelial growth factor receptor 2 | 5.5 | 5.5 | 5.5 | pKd | 1 |
Homo sapiens | Vascular endothelial growth factor receptor 2 | 5.9 | 5.9 | 5.9 | pKi | 1 |
Homo sapiens | Wee1-like protein kinase 2 | 6.3 | 6.3 | 6.7 | pKd | 2 |