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Search results (74 entries covering 26 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetails File
ROCK1DMPKAGC3ndmD(3s,4r)-n-(7-chloro-1-oxo-1,4-dihydroisoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamideHuman2705
ROCK1DMPKAGC5uzjAn-[4-(2-aminopyridin-4-yl)-1,3-thiazol-2-yl]-2-(3-methoxyphenyl)acetamideHuman9706
ROCK1DMPKAGC3ndmA-Human2695
ROCK1DMPKAGC5wnfAB1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1h-1,2,3-triazole-4-carboxamideHuman10444
ROCK1DMPKAGC3ndmC(3s,4r)-n-(7-chloro-1-oxo-1,4-dihydroisoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamideHuman2722
ROCK1DMPKAGC2etkB1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazineHuman2723
ROCK1DMPKAGC2etrB(r)-trans-4-(1-aminoethyl)-n-(4-pyridyl) cyclohexanecarboxamideHuman2704
ROCK1DMPKAGC3d9vA(s)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazineHuman2696
ROCK1DMPKAGC5wnhB(2r)-n-(3-cyanophenyl)-2-{3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}pyrrolidine-1-carboxamideHuman10449
ROCK1DMPKAGC3nczDcis-4-amino-n-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)cyclohexanecarboxamideHuman2724
ROCK1DMPKAGC2v55Cphosphoaminophosphonic acid-adenylate esterHuman2711
ROCK1DMPKAGC7s26A2-[methyl(phenyl)amino]-1-[4-(1h-pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydropyridin-1(2h)-yl]ethan-1-oneHuman14437
ROCK1DMPKAGC5wnfDA1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1h-1,2,3-triazole-4-carboxamideHuman10451
ROCK1DMPKAGC7s25AA2-[3-(methoxymethyl)phenyl]-n-[4-(1h-pyrazol-4-yl)phenyl]acetamideHuman14435
ROCK1DMPKAGC4w7pDn~1~-[2-(1h-indazol-5-yl)pyrido[3,4-d]pyrimidin-4-yl]-2-methylpropane-1,2-diamineHuman2712
ROCK1DMPKAGC3ndmB(3s,4r)-n-(7-chloro-1-oxo-1,4-dihydroisoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamideHuman2698
ROCK1DMPKAGC5wneC3,4-dimethoxy-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)benzamideHuman10462
ROCK1DMPKAGC5wnfCA1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1h-1,2,3-triazole-4-carboxamideHuman10455
ROCK1DMPKAGC4w7pCn~1~-[2-(1h-indazol-5-yl)pyrido[3,4-d]pyrimidin-4-yl]-2-methylpropane-1,2-diamineHuman2688
ROCK1DMPKAGC5bmlAn-[4-(2-fluoropyridin-4-yl)thiophen-2-yl]-2-{3-[(methylsulfonyl)amino]phenyl}acetamideHuman2713
ROCK1DMPKAGC4yvcA2-fluoro-n-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]benzamideHuman2715
ROCK1DMPKAGC6e9wBn-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamideHuman10690
ROCK1DMPKAGC5wneD3,4-dimethoxy-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)benzamideHuman10445
ROCK1DMPKAGC5hvuB2-{3-[3-(piperidin-4-yl)propoxy]phenyl}-n-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamideHuman7415
ROCK1DMPKAGC3d9vB(s)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazineHuman2701
ROCK1DMPKAGC3v8sA1-(1h-indazol-5-yl)-3-(2-phenylethyl)ureaHuman2716
ROCK1DMPKAGC3nczAcis-4-amino-n-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)cyclohexanecarboxamideHuman2699
ROCK1DMPKAGC5kktA2-[3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]-~{n}-[4-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamideHuman8182
ROCK1DMPKAGC5kksB2-[3-(methylsulfonylamino)phenyl]-~{n}-[4-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamideHuman8181
ROCK1DMPKAGC3tv7B1-[(1r)-1-(3-methoxyphenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaHuman2703
ROCK1DMPKAGC6e9wAn-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamideHuman10691
ROCK1DMPKAGC7s25AB2-[3-(methoxymethyl)phenyl]-n-[4-(1h-pyrazol-4-yl)phenyl]acetamideHuman14436
ROCK1DMPKAGC2etrA(r)-trans-4-(1-aminoethyl)-n-(4-pyridyl) cyclohexanecarboxamideHuman2700
ROCK1DMPKAGC2v55Aphosphoaminophosphonic acid-adenylate esterHuman2694
ROCK1DMPKAGC4yveA2-(3-methoxyphenyl)-n-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamideHuman2693
ROCK1DMPKAGC5wnhC(2r)-n-(3-cyanophenyl)-2-{3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}pyrrolidine-1-carboxamideHuman10456
ROCK1DMPKAGC4w7pBn~1~-[2-(1h-indazol-5-yl)pyrido[3,4-d]pyrimidin-4-yl]-2-methylpropane-1,2-diamineHuman2708
ROCK1DMPKAGC5wngA(2r)-n-(3-cyanophenyl)-2-(3-{[(6s)-6-(dimethylamino)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl]carbamoyl}phenyl)pyrrolidine-1-carboxamideHuman10459
ROCK1DMPKAGC3twjC1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaHuman2689
ROCK1DMPKAGC5wnfBB1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1h-1,2,3-triazole-4-carboxamideHuman10450
ROCK1DMPKAGC3twjD-Human2690
ROCK1DMPKAGC4w7pAn~1~-[2-(1h-indazol-5-yl)pyrido[3,4-d]pyrimidin-4-yl]-2-methylpropane-1,2-diamineHuman2721
ROCK1DMPKAGC5kksA2-[3-(methylsulfonylamino)phenyl]-~{n}-[4-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamideHuman8183
ROCK1DMPKAGC5wnhA(2r)-n-(3-cyanophenyl)-2-{3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}pyrrolidine-1-carboxamideHuman10448
ROCK1DMPKAGC5wngB(2r)-n-(3-cyanophenyl)-2-(3-{[(6s)-6-(dimethylamino)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl]carbamoyl}phenyl)pyrrolidine-1-carboxamideHuman10461
ROCK1DMPKAGC5wngC(2r)-n-(3-cyanophenyl)-2-(3-{[(6s)-6-(dimethylamino)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl]carbamoyl}phenyl)pyrrolidine-1-carboxamideHuman10458
ROCK1DMPKAGC3v8sD1-(1h-indazol-5-yl)-3-(2-phenylethyl)ureaHuman2692
ROCK1DMPKAGC5hvuA2-{3-[3-(piperidin-4-yl)propoxy]phenyl}-n-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamideHuman7414
ROCK1DMPKAGC5wnfDB1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1h-1,2,3-triazole-4-carboxamideHuman10452
ROCK1DMPKAGC5wnfBA1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1h-1,2,3-triazole-4-carboxamideHuman10463
ROCK1DMPKAGC3twjB-Human2718
ROCK1DMPKAGC5wneA3,4-dimethoxy-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)benzamideHuman10446
ROCK1DMPKAGC2etkA1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazineHuman2707
ROCK1DMPKAGC2esmA5-(1,4-diazepan-1-sulfonyl)isoquinolineHuman2726
ROCK1DMPKAGC5wnfCB1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1h-1,2,3-triazole-4-carboxamideHuman10460
ROCK1DMPKAGC3tv7C1-[(1r)-1-(3-methoxyphenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaHuman2717
ROCK1DMPKAGC3twjA1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaHuman2710
ROCK1DMPKAGC4yveB2-(3-methoxyphenyl)-n-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamideHuman2706
ROCK1DMPKAGC7jouAn-[(1s)-2-hydroxy-1-phenylethyl]-3-methoxy-4-(1h-pyrazol-4-yl)benzamideHuman12768
ROCK1DMPKAGC4yvcB2-fluoro-n-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]benzamideHuman2727
ROCK1DMPKAGC3v8sC1-(1h-indazol-5-yl)-3-(2-phenylethyl)ureaHuman2702
ROCK1DMPKAGC3nczBcis-4-amino-n-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)cyclohexanecarboxamideHuman2720
ROCK1DMPKAGC5bmlBn-[4-(2-fluoropyridin-4-yl)thiophen-2-yl]-2-{3-[(methylsulfonyl)amino]phenyl}acetamideHuman2691
ROCK1DMPKAGC5kktB2-[3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]-~{n}-[4-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamideHuman8184
ROCK1DMPKAGC3v8sB1-(1h-indazol-5-yl)-3-(2-phenylethyl)ureaHuman2709
ROCK1DMPKAGC3tv7D1-[(1r)-1-(3-methoxyphenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaHuman2725
ROCK1DMPKAGC5wneB3,4-dimethoxy-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)benzamideHuman10453
ROCK1DMPKAGC5wnhD(2r)-n-(3-cyanophenyl)-2-{3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}pyrrolidine-1-carboxamideHuman10454
ROCK1DMPKAGC5wnfAA1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-n-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1h-1,2,3-triazole-4-carboxamideHuman10447
ROCK1DMPKAGC2esmB5-(1,4-diazepan-1-sulfonyl)isoquinolineHuman2714
ROCK1DMPKAGC3nczCcis-4-amino-n-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)cyclohexanecarboxamideHuman2719
ROCK1DMPKAGC5wngD(2r)-n-(3-cyanophenyl)-2-(3-{[(6s)-6-(dimethylamino)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl]carbamoyl}phenyl)pyrrolidine-1-carboxamideHuman10457
ROCK1DMPKAGC5uzjBn-[4-(2-aminopyridin-4-yl)-1,3-thiazol-2-yl]-2-(3-methoxyphenyl)acetamideHuman9707
ROCK1DMPKAGC3tv7A1-[(1r)-1-(3-methoxyphenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)ureaHuman2697
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