KLIFS - the kinase structures database

Version: 2.4
Updated: 18-Sep-2019

C-abl oncogene 1, non-receptor tyrosine kinase

Kinase structure
Kinase:	Abl1 (ABL1)
Family:	Abl
Group:	TK
Species:	MOUSE
PDB:	1M52
sc-PDB:
KIDFamMap:	Search
Release date:	2002-09-18
PubMed:	12154025
Chain:	A
Orthosteric ligand:	P17

More entries for 1M52
1M52	Chain:	B

Structural information
DFG conformation:	out-like
αC-helix conformation:	in
G-rich loop angle (distance):	55.4° (16.8Å)
G-rich loop rotation:	1.2°
Quality Score:	8
Resolution:	2.6 Å
Missing Residues:	0
Missing Atoms:	0

Ligand binding mode
Pockets	Subpockets
front gate back	BP-I-A BP-I-B

Pocket alignment
Uniprot sequence:	HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITEFMTYGNLLDYLREYLEKKNFIHRDLAARNCLVVADFGLS
Sequence structure:	HKLGGGQYGEVYEVAVKTLEFLKEAAVMKEIKPNLVQLLGVYIITEFMTYGNLLDYLREYLEKKNFIHRDLAARNCLVVADFGLS

Ligand affinity
ChEMBL ID:	CHEMBL386051
Bioaffinities:	198 records for 148 kinases

Species	Kinase (ChEMBL naming)	Median	Min	Max	Type	Records
Homo sapiens	Activin receptor type-1	6.8	6.8	6.8	pKd	1
Homo sapiens	Activin receptor type-1B	7	7	7	pKd	1
Homo sapiens	Activin receptor type-2A	8	8	8	pKd	1
Homo sapiens	Activin receptor type-2B	8	8	8	pKd	1
Homo sapiens	Bone morphogenetic protein receptor type-1A	6.8	6.8	6.8	pKd	1
Homo sapiens	Bone morphogenetic protein receptor type-1B	8.4	8.4	8.4	pKd	1
Homo sapiens	BR serine/threonine-protein kinase 1	5.5	5.5	5.5	pKd	1
Homo sapiens	BR serine/threonine-protein kinase 2	5.1	5.1	5.1	pKd	1
Homo sapiens	c-Jun N-terminal kinase 1	5.8	5.8	5.8	pKd	1
Homo sapiens	Discoidin domain-containing receptor 2	7.9	7.9	7.9	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 1	6.1	6.1	6.1	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 2	5.7	5.7	5.7	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 3	5.3	5.3	5.3	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 4	6.5	6.5	6.5	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 5	7.2	7.2	7.2	pKd	1
Homo sapiens	Dual specificity mitogen-activated protein kinase kinase 6	5.4	5.4	5.4	pKd	1
Homo sapiens	Dual specificity testis-specific protein kinase 1	7.1	7.1	7.1	pKd	1
Homo sapiens	Ephrin type-A receptor 1	8.2	8.2	8.2	pKd	1
Homo sapiens	Ephrin type-A receptor 2	8.4	8.4	8.4	pKd	1
Homo sapiens	Ephrin type-A receptor 3	8.1	8.1	8.1	pKd	1
Homo sapiens	Ephrin type-A receptor 4	8.1	8.1	8.1	pKd	1
Homo sapiens	Ephrin type-A receptor 5	7.9	7.9	7.9	pKd	1
Homo sapiens	Ephrin type-A receptor 6	7.2	7.2	7.2	pKd	1
Homo sapiens	Ephrin type-A receptor 8	8.2	8.2	8.2	pKd	1
Homo sapiens	Ephrin type-B receptor 1	8.4	8.4	8.4	pKd	1
Homo sapiens	Ephrin type-B receptor 2	7.7	7.7	7.7	pKd	1
Homo sapiens	Ephrin type-B receptor 3	6.5	6.5	6.5	pKd	1
Homo sapiens	Ephrin type-B receptor 4	7.9	7.9	7.9	pKd	1
Homo sapiens	Epidermal growth factor receptor erbB1	6	5.6	6.8	pKd	10
Homo sapiens	Epithelial discoidin domain-containing receptor 1	8.6	8.6	8.6	pKd	1
Homo sapiens	Eukaryotic translation initiation factor 2-alpha kinase 4	7.6	7.6	7.6	pKd	1
Homo sapiens	Fibroblast growth factor receptor 1	5.9	5.9	5.9	pIC50	1
Homo sapiens	Fibroblast growth factor receptor 1	7.2	7.2	7.2	pKd	1
Homo sapiens	Fibroblast growth factor receptor 2	7.5	7.5	7.5	pKd	1
Homo sapiens	Fibroblast growth factor receptor 3	7.3	7.3	7.3	pKd	2
Homo sapiens	Fibroblast growth factor receptor 4	6.3	6.3	6.3	pKd	1
Homo sapiens	Hepatocyte growth factor receptor	6.1	6	6.1	pKd	3
Homo sapiens	Leucine-rich repeat serine/threonine-protein kinase 2	5.1	5.1	5.3	pKd	2
Homo sapiens	LIM domain kinase 1	6	6	6	pKd	1
Homo sapiens	LIM domain kinase 2	6.5	6.5	6.5	pKd	1
Homo sapiens	Macrophage colony stimulating factor receptor	9.2	9.2	9.2	pKd	1
Homo sapiens	Macrophage-stimulating protein receptor	5.6	5.6	5.6	pKd	1
Homo sapiens	MAP kinase p38 alpha	7.2	7.2	7.2	pKd	1
Homo sapiens	MAP kinase p38 beta	7	7	7	pKd	1
Homo sapiens	MAP/microtubule affinity-regulating kinase 2	5	5	5	pKd	1
Homo sapiens	Misshapen-like kinase 1	6.2	6.2	6.2	pKd	1
Homo sapiens	Mitogen-activated protein kinase 4	6	6	6	pKd	1
Homo sapiens	Mitogen-activated protein kinase 6	6.8	6.8	6.8	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 10	5.3	5.3	5.3	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 11	6.3	6.3	6.3	pKd	2
Homo sapiens	Mitogen-activated protein kinase kinase kinase 2	6.2	6.2	6.2	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 3	6.4	6.4	6.4	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 4	7.3	7.3	7.3	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase 9	6.4	6.4	6.4	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 1	6.7	6.7	6.7	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 2	5.9	5.9	5.9	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 3	6.4	6.4	6.4	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 4	6.1	6.1	6.1	pKd	1
Homo sapiens	Mitogen-activated protein kinase kinase kinase kinase 5	6.6	6.6	6.6	pKd	1
Homo sapiens	Mixed lineage kinase 7	6.5	6.5	6.5	pKd	1
Homo sapiens	Myosin light chain kinase	6.9	6.9	6.9	pKd	1
Homo sapiens	myosin light chain kinase 2	6.7	6.7	6.7	pKd	1
Homo sapiens	Non-receptor tyrosine-protein kinase TNK1	6.4	6.4	6.4	pKd	1
Homo sapiens	NT-3 growth factor receptor	5.2	5.2	5.2	pKd	1
Homo sapiens	Platelet-derived growth factor receptor alpha	8.3	8.3	8.3	pKd	1
Homo sapiens	Platelet-derived growth factor receptor beta	8.9	8.9	8.9	pKd	1
Homo sapiens	Protein tyrosine kinase 2 beta	5.3	5.3	5.3	pKd	1
Homo sapiens	Putative uncharacterized serine/threonine-protein kinase SgK110	6	6	6	pKd	1
Homo sapiens	Receptor-interacting serine/threonine-protein kinase 1	5.5	5.5	5.5	pKd	1
Homo sapiens	Receptor protein-tyrosine kinase erbB-4	6	6	6	pKd	1
Homo sapiens	Receptor tyrosine-protein kinase erbB-3	6.9	6.9	6.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase 10	5.8	5.8	5.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase 2	5.4	5.4	5.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase 24	5.6	5.6	5.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase 25	5.6	5.6	5.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase 32A	5.6	5.6	5.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase 32B	5.9	5.9	5.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase 35	6.4	6.4	6.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase 36	6.5	6.5	6.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase Aurora-C	5.3	5.3	5.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase B-raf	8.2	8.2	8.4	pKd	2
Homo sapiens	Serine/threonine-protein kinase c-TAK1	6.1	6.1	6.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase GAK	8.1	8.1	8.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase MRCK-A	5.9	5.9	5.9	pKd	1
Homo sapiens	Serine/threonine-protein kinase MRCK beta	6	6	6	pKd	1
Homo sapiens	Serine/threonine-protein kinase MRCK gamma	6.6	6.6	6.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase MST1	5.4	5.4	5.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase MST2	5.8	5.8	5.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase MST4	5.4	5.4	5.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase Nek1	5.1	5.1	5.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase Nek11	5.5	5.5	5.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase NEK2	7	7	7	pKd	1
Homo sapiens	Serine/threonine-protein kinase Nek5	6.1	6.1	6.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase NIM1	5.2	5.2	5.2	pKd	1
Homo sapiens	Serine/threonine protein kinase NLK	7.5	7.5	7.5	pKd	1
Homo sapiens	Serine/threonine-protein kinase PLK3	5.7	5.7	5.7	pKd	1
Homo sapiens	Serine/threonine-protein kinase RAF	7.6	7.6	7.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase receptor R3	7.2	7.2	7.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase RIPK2	7.8	7.8	7.8	pKd	1
Homo sapiens	Serine/threonine-protein kinase SIK1	8.2	8.2	8.2	pKd	1
Homo sapiens	Serine/threonine-protein kinase SIK2	7.6	7.6	7.6	pKd	1
Homo sapiens	Serine/threonine-protein kinase SIK3	7	7	7	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO1	6.1	6.1	6.1	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO2	6.4	6.4	6.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase TAO3	6.4	6.4	6.4	pKd	1
Homo sapiens	Serine/threonine-protein kinase TNNI3K	7.3	7.3	7.3	pKd	1
Homo sapiens	Serine/threonine-protein kinase WEE1	7.2	7.2	7.2	pKd	1
Homo sapiens	SPS1/STE20-related protein kinase YSK4	6.6	6.6	6.6	pKd	1
Homo sapiens	Stem cell growth factor receptor	7.5	6.3	8.8	pKd	7
Homo sapiens	TGF-beta receptor type I	5.8	5.8	5.8	pKd	1
Homo sapiens	TGF-beta receptor type II	6.6	6.6	6.6	pKd	1
Homo sapiens	TRAF2- and NCK-interacting kinase	6.4	6.4	6.4	pKd	1
Homo sapiens	Tyrosine- and threonine-specific cdc2-inhibitory kinase	7.4	7.4	7.4	pKd	1
Homo sapiens	Tyrosine kinase non-receptor protein 2	7.6	7.6	7.6	pKd	1
Homo sapiens	Tyrosine-protein kinase ABL	8.9	5.7	9.3	pKd	15
Homo sapiens	Tyrosine-protein kinase ABL	9.7	9.7	9.7	pKi	1
Homo sapiens	Tyrosine-protein kinase ABL2	9.2	9.2	9.2	pKd	1
Homo sapiens	Tyrosine-protein kinase BLK	8.8	8.8	8.8	pKd	1
Homo sapiens	Tyrosine-protein kinase BMX	7.5	7.5	7.5	pKd	1
Homo sapiens	Tyrosine-protein kinase BRK	7.3	7.3	7.3	pKd	1
Homo sapiens	Tyrosine-protein kinase BTK	6.7	6.7	6.7	pKd	1
Homo sapiens	Tyrosine-protein kinase CSK	7.2	7.2	7.2	pKd	1
Homo sapiens	Tyrosine-protein kinase FER	5.5	5.5	5.5	pKd	1
Homo sapiens	Tyrosine-protein kinase FES	6.2	6.2	6.2	pKd	1
Homo sapiens	Tyrosine-protein kinase FGR	8.6	8.6	8.6	pKd	1
Homo sapiens	Tyrosine-protein kinase FRK	8.4	8.4	8.4	pKd	1
Homo sapiens	Tyrosine-protein kinase FYN	8.3	8.3	8.3	pKd	1
Homo sapiens	Tyrosine-protein kinase HCK	8.5	8.5	8.5	pKd	1
Homo sapiens	Tyrosine-protein kinase JAK1	6.5	6.5	6.5	pKd	2
Homo sapiens	Tyrosine-protein kinase JAK2	7	7	7	pKd	2
Homo sapiens	Tyrosine-protein kinase JAK3	6.3	6.3	6.3	pKd	2
Homo sapiens	Tyrosine-protein kinase LCK	9	9	9	pKd	1
Homo sapiens	Tyrosine-protein kinase Lyn	8.7	8.7	8.7	pKd	1
Homo sapiens	Tyrosine-protein kinase receptor FLT3	6.1	5.5	6.9	pKd	7
Homo sapiens	Tyrosine-protein kinase receptor RET	7.2	5.2	7.3	pKd	3
Homo sapiens	Tyrosine-protein kinase receptor Tie-1	5.9	5.9	5.9	pKd	1
Homo sapiens	Tyrosine-protein kinase receptor TYRO3	6.4	6.4	6.4	pKd	1
Homo sapiens	Tyrosine-protein kinase SRC	7.6	7.6	7.6	pIC50	1
Homo sapiens	Tyrosine-protein kinase SRC	9.2	9.2	9.2	pKd	1
Homo sapiens	Tyrosine-protein kinase Srms	6.2	6.2	6.2	pKd	1
Homo sapiens	Tyrosine-protein kinase SYK	6.4	6.4	6.4	pKd	1
Homo sapiens	Tyrosine-protein kinase TEC	6.2	6.2	6.2	pKd	1
Homo sapiens	Tyrosine-protein kinase TIE-2	6.6	6.6	6.6	pKd	1
Homo sapiens	Tyrosine-protein kinase TXK	7.5	7.5	7.5	pKd	1
Homo sapiens	Tyrosine-protein kinase TYK2	6.4	6.4	6.4	pKd	2
Homo sapiens	Tyrosine-protein kinase YES	8.6	8.6	8.6	pKd	1
Homo sapiens	Uncharacterized aarF domain-containing protein kinase 4	7.6	7.6	7.6	pKd	1
Homo sapiens	Vascular endothelial growth factor receptor 1	7.6	7.6	7.6	pKd	1
Homo sapiens	Vascular endothelial growth factor receptor 2	6.2	6.2	6.2	pKd	1
Homo sapiens	Vascular endothelial growth factor receptor 3	6.1	6.1	6.1	pKd	1
Homo sapiens	Wee1-like protein kinase 2	7.2	7.2	7.2	pKd	1

Kinase-ligand interaction pattern

• Hydrophobic • Aromatic face-to-face • Aromatic face-to-edge • H-bond donor • H-bond acceptor • Ionic positive • Ionic negative

g.l

III

αC

1 H
246

2 K
247

3 L
248

4 G
249

5 G
250

6 G
251

7 Q
252

8 Y
253

9 G
254

10 E
255

11 V
256

12 Y
257

13 E
258

14 V
268

15 A
269

16 V
270

17 K
271

18 T
272

19 L
273

20 E
282

•

αC

b.l

21 F
283

22 L
284

23 K
285

24 E
286

25 A
287

26 A
288

27 V
289

28 M
290

29 K
291

30 E
292

31 I
293

32 K
294

33 P
296

34 N
297

35 L
298

36 V
299

37 Q
300

38 L
301

39 L
302

40 G
303

•

hinge

linker

αD

αE

41 V
304

42 Y
312

43 I
313

44 I
314

45 T
315

46 E
316

47 F
317

48 M
318

49 T
319

50 Y
320

51 G
321

52 N
322

53 L
323

54 L
324

55 D
325

56 Y
326

57 L
327

58 R
328

59 E
329

60 Y
353

•

••

•••

•

αE

c.l

VII

VIII

61 L
354

62 E
355

63 K
356

64 K
357

65 N
358

66 F
359

67 I
360

68 H
361

69 R
362

70 D
363

71 L
364

72 A
365

73 A
366

74 R
367

75 N
368

76 C
369

77 L
370

78 V
371

79 V
379

80 A
380

•

DFG

a.l

81 D
381

82 F
382

83 G
383

84 L
384

85 S
385

••

Interaction pattern search

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