KLIFS - the structural kinase database

Searching for structures with analogs of Lazertinib.

Search results (25 entries covering 16 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
IRAK4	IRAK	TKL	6egd	D	A	n-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide	Human	10894	0.41
EGFR	EGFR	TK	7jxw	A	A	n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide	Human	13875	0.46
EGFR	EGFR	TK	6jx0	A		n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide	Human	12175	0.46
EGFR	EGFR	TK	6jx4	A		n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide	Human	12176	0.46
EGFR	EGFR	TK	4zau	A		n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide	Human	6221	0.46
EGFR	EGFR	TK	7jxw	A	B	n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide	Human	13877	0.46
EGFR	EGFR	TK	6jxt	A	A	n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide	Human	12240	0.46
EGFR	EGFR	TK	7jxl	A	A	n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-5-{[4-(1h-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl)propanamide	Human	13878	0.46
EGFR	EGFR	TK	3ika	A	A	n-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide	Human	802	0.41
EGFR	EGFR	TK	7ukv	A		n-[5-{[(4p)-4-{4-[(dimethylamino)methyl]-3-phenyl-1h-pyrazol-1-yl}pyrimidin-2-yl]amino}-4-methoxy-2-(morpholin-4-yl)phenyl]propanamide	Human	14528	0.83
EGFR	EGFR	TK	5xdl	A		n-[3-[[2-[[4-(4-ethanoylpiperazin-1-yl)-2-methoxy-phenyl]amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide	Human	9066	0.40
EGFR	EGFR	TK	5gtz	A	A	n-[5-[[5-chloranyl-4-[(2-propan-2-ylsulfonylphenyl)amino]pyrimidin-2-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxy-phenyl]prop-2-enamide	Human	8365	0.49
EGFR	EGFR	TK	3ika	A	B	n-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide	Human	855	0.41
EGFR	EGFR	TK	5x2k	A		n-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide	Human	9568	0.41
EGFR	EGFR	TK	5gtz	A	B	n-[5-[[5-chloranyl-4-[(2-propan-2-ylsulfonylphenyl)amino]pyrimidin-2-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxy-phenyl]prop-2-enamide	Human	8361	0.49
EGFR	EGFR	TK	6lud	A		n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide	Human	12919	0.46
EGFR	EGFR	TK	7zyn	A	B	n-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide	Human	14728	0.41
EGFR	EGFR	TK	6jwl	A		n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide	Human	12173	0.46
EGFR	EGFR	TK	7jxl	A	B	n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-5-{[4-(1h-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl)propanamide	Human	13879	0.46
EGFR	EGFR	TK	5xdk	A		n-[3-[[2-[[4-(4-ethanoylpiperazin-1-yl)-2-methoxy-phenyl]amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide	Human	9065	0.40
EGFR	EGFR	TK	7zyn	A	A	n-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide	Human	14727	0.41
EGFR	EGFR	TK	6jxt	A	B	n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide	Human	12239	0.46
IRAK4	IRAK	TKL	6egd	D	B	n-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide	Human	10890	0.41
IRAK4	IRAK	TKL	6egd	A	B	n-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide	Human	10892	0.41
IRAK4	IRAK	TKL	6egd	A	A	n-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide	Human	10895	0.41