KLIFS - the structural kinase database

Searching for structures with analogs of Lerociclib.

Kinase	Family	Group	PDB	Chain	Orthosteric ligand	Organism	Details	Similarity (MFP)
CDK6	CDK	CMGC	3nux	A	4-[5-chloro-3-(1-methylethyl)-1h-pyrazol-4-yl]-n-(5-piperazin-1-ylpyridin-2-yl)pyrimidin-2-amine	Human	2807	0.47
CDK6	CDK	CMGC	5l2t	A	7-cyclopentyl-n,n-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7h-pyrrolo[2,3-d]pyrimidine-6-carboxamide	Human	6992	0.51
CDK6	CDK	CMGC	2euf	B	6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7(8h)-one	Human	2804	0.46
CDK6	CDK	CMGC	4tth	B	9-cyclopentyl-n-(5-piperazin-1-ylpyridin-2-yl)pyrido[4,5]pyrrolo[1,2-d]pyrimidin-2-amine	Human	2803	0.45
CDK6	CDK	CMGC	5l2i	A	6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7(8h)-one	Human	6991	0.46