Searching for structures with analogs of Midostaurin.

Search results (175 entries covering 89 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetailsSimilarity (MFP)File
ITKTecTK1snuBstaurosporineHuman330.72
ITKTecTK1sm2BstaurosporineHuman730.72
ITKTecTK1snuAstaurosporineHuman820.72
PRKAA1 (AMPKa1)CAMKLCAMK4rerAstaurosporineHuman1210.72
PAK1STE20STE2hy81(5s,6r,7r,9r)-12-hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9-tetrahydro-5h,14h-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-oneHuman1720.48
PRKAA2 (AMPKa2)CAMKLCAMK4cffCstaurosporineHuman1900.72
PRKAA2 (AMPKa2)CAMKLCAMK4cfeCstaurosporineHuman1920.72
IKBKB (IKKb)IKKOther4kikABk-252aHuman2880.62
IKBKB (IKKb)IKKOther4kikAAk-252aHuman2900.62
IKBKB (IKKb)IKKOther4kikBBk-252aHuman2930.62
IKBKB (IKKb)IKKOther4kikBAk-252aHuman2950.62
EPHB4 (EphB4)EphTK2yn8BstaurosporineHuman3490.72
EPHB4 (EphB4)EphTK3zewBAstaurosporineHuman3510.72
EPHB4 (EphB4)EphTK2yn8AstaurosporineHuman3520.72
EPHB4 (EphB4)EphTK3zewBBstaurosporineHuman3570.72
EPHB4 (EphB4)EphTK3zewAAstaurosporineHuman3730.72
JAK3JakATK1yvjAB1,2,3,4-tetrahydrogen-staurosporineHuman4510.61
JAK3JakATK1yvjAA1,2,3,4-tetrahydrogen-staurosporineHuman4600.61
PKN1PKNAGC4otgAAlestaurtinibHuman5480.41
PKN1PKNAGC4otgABlestaurtinibHuman5490.41
MKNK2 (MNK2)MAPKAPKCAMK2hw7AstaurosporineHuman7640.72
EGFREGFRTK2ituAA1,2,3,4-tetrahydrogen staurosporineHuman7790.43
EGFREGFRTK2itqAA1,2,3,4-tetrahydrogen staurosporineHuman8130.43
EGFREGFRTK2itwAA1,2,3,4-tetrahydrogen staurosporineHuman8170.43
EGFREGFRTK2itqAB1,2,3,4-tetrahydrogen staurosporineHuman8460.43
EGFREGFRTK2ituAB1,2,3,4-tetrahydrogen staurosporineHuman8590.43
EGFREGFRTK2itwAB1,2,3,4-tetrahydrogen staurosporineHuman9140.43
ABL1AblTK2hz4B1,2,3,4-tetrahydrogen-staurosporineHuman10580.61
SYKSykTK1xbcAAstaurosporineHuman11650.72
MAP2K6STE7STE3fmeAstaurosporineHuman12310.72
SYKSykTK1xbcABstaurosporineHuman12070.72
LIMK1LISKTKL3s95BAstaurosporineHuman12450.72
LIMK1LISKTKL3s95AAstaurosporineHuman12460.72
LIMK1LISKTKL3s95BBstaurosporineHuman12470.72
MAPKAPK2MAPKAPKCAMK2pzyCstaurosporineHuman12790.72
MELKCAMKLCAMK5m5aABk-252aHuman87330.62
CHEK1 (CHK1)CAMKLCAMK1nvsArel-(9r,12s)-9,10,11,12-tetrahydro-9,12-epoxy-1h-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2h)-dioneHuman15910.40
CHEK1 (CHK1)CAMKLCAMK1nvqA7-hydroxystaurosporineHuman16420.54
IRAK4IRAKTKL2nryDBstaurosporineHuman17460.72
IRAK4IRAKTKL2nryCBstaurosporineHuman17500.72
IRAK4IRAKTKL4u9aAstaurosporineHuman17510.72
IRAK4IRAKTKL4u97BstaurosporineHuman17420.72
IRAK4IRAKTKL4u97AstaurosporineHuman17540.72
IRAK4IRAKTKL2nryAAstaurosporineHuman17530.72
IRAK4IRAKTKL2nryBBstaurosporineHuman17720.72
IRAK4IRAKTKL2nryABstaurosporineHuman17770.72
IRAK4IRAKTKL2nryCAstaurosporineHuman17790.72
LYNSrcTK3a4oXstaurosporineHuman18120.72
RPS6KB1 (p70S6K)RSKAGC3a61AstaurosporineHuman18460.72
RPS6KB1 (p70S6K)RSKAGC3a60AstaurosporineHuman18520.72
RPS6KB1 (p70S6K)RSKAGC3a60BstaurosporineHuman18560.72
FYNSrcTK2dq7XstaurosporineHuman19410.72
STK16 (MPSK1)NAKOther2bujBstaurosporineHuman22300.72
STK16 (MPSK1)NAKOther2bujAstaurosporineHuman22290.72
PIM1PIMCAMK1yhsAstaurosporineHuman24440.72
ZAP70SykTK1u59ABstaurosporineHuman27330.72
ZAP70SykTK1u59AAstaurosporineHuman27340.72
RPS6KA2 (RSK1)RSKAGC2z7rAstaurosporineHuman27770.72
FESFerTK3bkbAAstaurosporineHuman28100.72
FESFerTK3cblABstaurosporineHuman28110.72
FESFerTK3bkbABstaurosporineHuman28130.72
FESFerTK3cd3AAstaurosporineHuman28140.72
FESFerTK3cd3ABstaurosporineHuman28150.72
CSKCskTK3d7tAstaurosporineHuman29410.72
METMetTK1r0pAk-252aHuman29910.62
PDPK1 (PDK1)PDK1AGC1okyAAstaurosporineHuman31640.72
PDPK1 (PDK1)PDK1AGC1okyABstaurosporineHuman31950.72
PDPK1 (PDK1)PDK1AGC1okzA7-hydroxystaurosporineHuman32090.54
MAP2K1STE7STE3eqfAk-252aHuman33170.62
DYRK1ADYRKCMGC4nctBpkc412Human37431.00
DYRK1ADYRKCMGC4nctDpkc412Human37511.00
DYRK1ADYRKCMGC4nctCpkc412Human37791.00
DYRK1ADYRKCMGC4nctApkc412Human37941.00
AAK1NAKOther4wsqBAk-252aHuman38330.62
CDK2CDKCMGC1pkdC7-hydroxystaurosporineHuman39730.54
CDK2CDKCMGC1pkdA7-hydroxystaurosporineHuman41700.54
CDK2CDKCMGC4ez7AstaurosporineHuman42400.72
CDK2CDKCMGC4erwAstaurosporineHuman43700.72
STK32A (YANK1)YANKAGC4fr4FBstaurosporineHuman46860.72
STK32A (YANK1)YANKAGC4fr4DBstaurosporineHuman46870.72
STK32A (YANK1)YANKAGC4fr4EAstaurosporineHuman46890.72
STK32A (YANK1)YANKAGC4fr4ABstaurosporineHuman46900.72
STK32A (YANK1)YANKAGC4fr4FAstaurosporineHuman46910.72
STK32A (YANK1)YANKAGC4fr4BAstaurosporineHuman46920.72
STK32A (YANK1)YANKAGC4fr4AAstaurosporineHuman46930.72
STK32A (YANK1)YANKAGC4fr4CBstaurosporineHuman46940.72
STK32A (YANK1)YANKAGC4fr4BBstaurosporineHuman46950.72
MAP3K5STE11STE2clqBBstaurosporineHuman47320.72
MAP3K5STE11STE4bf2AstaurosporineHuman47430.72
MAP3K5STE11STE4bf2BstaurosporineHuman47450.72
MAP3K5STE11STE2clqABstaurosporineHuman47360.72
MAP3K5STE11STE2clqAAstaurosporineHuman47400.72
PRKCQ (PKCt)PKCAGC1xjdAstaurosporineHuman53570.72
ALKALKTK3lcsABstaurosporineHuman53760.72
ALKALKTK3lcsAAstaurosporineHuman53810.72
STK24 (MST3)STE20STE4qmyAstaurosporineHuman55920.72
STK24 (MST3)STE20STE3ckxAstaurosporineHuman55990.72
LIMK1LISKTKL3s95ABstaurosporineHuman12480.72
RPS6KB1 (p70S6K)RSKAGC3a62AstaurosporineHuman18670.72
IRAK4IRAKTKL4u9aBstaurosporineHuman17920.72
FESFerTK3cblAAstaurosporineHuman28080.72
CSKCskTK1bygAstaurosporineHuman29430.72
STK32A (YANK1)YANKAGC4fr4CAstaurosporineHuman46840.72
STK32A (YANK1)YANKAGC4fr4DAstaurosporineHuman46880.72
TTKTTKOther3hmoAstaurosporineHuman47070.72
EPHB4 (EphB4)EphTK3zewABstaurosporineHuman3770.72
PRKAA1 (AMPKa1)CAMKLCAMK4rewAstaurosporineHuman1240.72
PRKAA2 (AMPKa2)CAMKLCAMK4cfeAstaurosporineHuman1950.72
CHEK1 (CHK1)CAMKLCAMK1nvrAstaurosporineHuman15850.72
FESFerTK3bkbACstaurosporineHuman28120.72
STK32A (YANK1)YANKAGC4fr4EBstaurosporineHuman46850.72
DAPK1DAPKCAMK1wvyAstaurosporineHuman56610.72
ERN1 (IRE1)IREOther4yzcBAstaurosporineHuman62270.72
ERN1 (IRE1)IREOther4yzcBBstaurosporineHuman62310.72
ERN1 (IRE1)IREOther4yzcABstaurosporineHuman62320.72
PRKAA2 (AMPKa2)CAMKLCAMK5ezvAAstaurosporineHuman64240.72
PRKAA2 (AMPKa2)CAMKLCAMK5ezvCBstaurosporineHuman64260.72
PRKAA2 (AMPKa2)CAMKLCAMK5ezvABstaurosporineHuman64280.72
PRKAA2 (AMPKa2)CAMKLCAMK5ezvCAstaurosporineHuman64300.72
TGFBR1 (TGFbR1)STKRTKL5e8wAAstaurosporineHuman66110.72
TGFBR1 (TGFbR1)STKRTKL5e8wABstaurosporineHuman66140.72
TGFBR2 (TGFbR2)STKRTKL5e8yAstaurosporineHuman66270.72
TGFBR1 (TGFbR1)STKRTKL5e8xABstaurosporineHuman66170.72
TGFBR1 (TGFbR1)STKRTKL5e8xAAstaurosporineHuman66150.72
ITKTecTK1sm2AstaurosporineHuman740.72
AAK1NAKOther4wsqAAk-252aHuman38340.62
AAK1NAKOther4wsqBBk-252aHuman38350.62
AAK1NAKOther4wsqABk-252aHuman38360.62
IRAK4IRAKTKL2nryBAstaurosporineHuman17580.72
IRAK4IRAKTKL2nryDAstaurosporineHuman17890.72
ERN1 (IRE1)IREOther4yzcAAstaurosporineHuman62350.72
PRKAA2 (AMPKa2)CAMKLCAMK4cffAstaurosporineHuman1910.72
MAP3K5STE11STE2clqBAstaurosporineHuman47550.72
MASTLMASTAGC5lohABstaurosporineHuman70850.72
MASTLMASTAGC5lohAAstaurosporineHuman70860.72
MASTLMASTAGC5lohBBstaurosporineHuman70870.72
MASTLMASTAGC5lohBAstaurosporineHuman70880.72
RIPK2RIPKTKL5ng2ABstaurosporineHuman80560.72
RIPK2RIPKTKL5ng2AAstaurosporineHuman80500.72
RIPK2RIPKTKL5ng2BBstaurosporineHuman80520.72
RIPK2RIPKTKL5ng2BAstaurosporineHuman80530.72
Prkaa1 (AMPKa1)CAMKLCAMK5ufuAstaurosporineMouse75900.72
RPS6KB1 (p70S6K)RSKAGC4rloBstaurosporineHuman72200.72
PRKAA2 (AMPKa2)CAMKLCAMK5isoCstaurosporineHuman79800.72
PRKAA2 (AMPKa2)CAMKLCAMK5isoAstaurosporineHuman79810.72
LCKSrcTK1qpdAstaurosporineHuman22670.72
MELKCAMKLCAMK5m5aAAk-252aHuman87350.62
EGFREGFRTK5xgnA12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5h-indolo[2,3-a]pyrrolo[3,4-c]carbazoleHuman85530.40
EGFREGFRTK5xgmA12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5h-indolo[2,3-a]pyrrolo[3,4-c]carbazoleHuman85520.40
PAK4STE20STE5vedAstaurosporineHuman85700.72
CHEK1 (CHK1)CAMKLCAMK5oorAstaurosporineHuman86030.72
MAPKAPK2MAPKAPKCAMK1nxkDstaurosporineHuman13340.72
MAPKAPK2MAPKAPKCAMK1nxkCstaurosporineHuman13120.72
GSK3BGSKCMGC1q3dAstaurosporineHuman7050.72
PRKAA2 (AMPKa2)CAMKLCAMK6b1uCBstaurosporineHuman98500.72
PRKAA2 (AMPKa2)CAMKLCAMK6b1uABstaurosporineHuman98490.72
PRKAA2 (AMPKa2)CAMKLCAMK6b1uAAstaurosporineHuman98480.72
PRKAA2 (AMPKa2)CAMKLCAMK6b1uCAstaurosporineHuman98470.72
PRKAA2 (AMPKa2)CAMKLCAMK6b2eAstaurosporineHuman98510.72
MAPKAPK2MAPKAPKCAMK1nxkBstaurosporineHuman12920.72
Ripk4 (ANKRD3)RIPKTKL5wnjAlestaurtinibMouse98930.41
MAPKAPK2MAPKAPKCAMK1nxkAstaurosporineHuman13420.72
Ripk4 (ANKRD3)RIPKTKL5wnlAstaurosporineMouse98910.72
PRKAA1 (AMPKa1)CAMKLCAMK6c9hAstaurosporineHuman107140.72
PRKAA1 (AMPKa1)CAMKLCAMK6c9gAstaurosporineHuman107150.72
PRKAA1 (AMPKa1)CAMKLCAMK6c9jAstaurosporineHuman107170.72
PRKAA1 (AMPKa1)CAMKLCAMK6c9fAstaurosporineHuman107160.72
CDK2CDKCMGC1aq1AstaurosporineHuman42670.72
PIK3CG (p110g)PIKAtypical1e8zAstaurosporineHuman92280.72
IRAK4IRAKTKL2oicBstaurosporineHuman17520.72
IRAK4IRAKTKL2oicAstaurosporineHuman17390.72
IRAK4IRAKTKL2oicCstaurosporineHuman17340.72
IRAK4IRAKTKL2oicDstaurosporineHuman17550.72
GSK3BGSKCMGC1q3dBstaurosporineHuman7520.72
LCKSrcTK1qpjAstaurosporineHuman22830.72