KLIFS - the structural kinase database

Searching for structures with analogs of Allitinib.

Search results (32 entries covering 16 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
EGFR	EGFR	TK	4i23	A		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide	Human	870	0.43
EGFR	EGFR	TK	4lrm	B		n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	Human	867	0.44
EGFR	EGFR	TK	4ll0	A		n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	Human	804	0.44
EGFR	EGFR	TK	4ll0	B		n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	Human	796	0.44
EGFR	EGFR	TK	4i24	B		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide	Human	910	0.43
EGFR	EGFR	TK	4lrm	C		n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	Human	781	0.44
EGFR	EGFR	TK	1xkk	A		n-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine	Human	844	0.57
JAK3	JakA	TK	4z16	C		n-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide	Human	6397	0.40
TTBK2	TTBK	CK1	6u0k	B	A	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12049	0.41
TTBK2	TTBK	CK1	6u0k	A	A	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12046	0.41
EGFR	EGFR	TK	4i24	A		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide	Human	831	0.43
CDK2	CDK	CMGC	1di8	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	4577	0.41
EGFR	EGFR	TK	2j5f	A		n-[4-(3-bromo-phenylamino)-quinazolin-6-yl]-acrylamide	Human	862	0.59
EGFR	EGFR	TK	8hy7	A		~{n}-[3-[[6-fluoranyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]quinazolin-4-yl]amino]phenyl]prop-2-enamide	Human	14941	0.44
JAK3	JakA	TK	4z16	D		n-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide	Human	6394	0.40
ERBB4 (ErbB4)	EGFR	TK	3bbt	B		n-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine	Human	2825	0.57
PRKACA (PKACa)	PKA	AGC	6frx	A		~{n}-[3-[(5-chloranyl-2-phenylazanyl-pyrimidin-4-yl)amino]phenyl]prop-2-enamide	Human	11261	0.43
EGFR	EGFR	TK	4lrm	D		n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	Human	786	0.44
EGFR	EGFR	TK	4lrm	A		n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	Human	901	0.44
EGFR	EGFR	TK	4lrm	E		n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide	Human	825	0.44
JAK3	JakA	TK	4z16	B		n-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide	Human	6396	0.40
JAK3	JakA	TK	4z16	A		n-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide	Human	6395	0.40
RET	Ret	TK	5amn	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	6412	0.41
TTBK1	TTBK	CK1	4btk	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	771	0.41
ERBB4 (ErbB4)	EGFR	TK	3bbt	D		n-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine	Human	2819	0.57
ERBB4 (ErbB4)	EGFR	TK	2r4b	B	B	n-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-ethylthieno[3,2-d]pyrimidin-4-amine	Human	2823	0.56
ERBB4 (ErbB4)	EGFR	TK	2r4b	A	B	n-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-ethylthieno[3,2-d]pyrimidin-4-amine	Human	2827	0.56
ERBB4 (ErbB4)	EGFR	TK	2r4b	B	A	n-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-ethylthieno[3,2-d]pyrimidin-4-amine	Human	2818	0.56
ERBB4 (ErbB4)	EGFR	TK	2r4b	A	A	n-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-ethylthieno[3,2-d]pyrimidin-4-amine	Human	2822	0.56
EGFR	EGFR	TK	4lqm	A		n-[4-(3-bromo-phenylamino)-quinazolin-6-yl]-acrylamide	Human	785	0.59
TTBK2	TTBK	CK1	6u0k	B	B	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12047	0.41
TTBK2	TTBK	CK1	6u0k	A	B	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12048	0.41