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Searching for structures with analogs of Seliciclib.

Search results (75 entries covering 41 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetailsSimilarity (MFP)File
CSNK1G3 (CK1g3)CK1CK12izuAA2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9h-purin-2-yl}amino)-3-methylbutan-1-olHuman22180.49
MERTK (MER)AxlTK3bprDB2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurineHuman2820.46
MERTK (MER)AxlTK3bprDA2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurineHuman2790.46
MERTK (MER)AxlTK3bprBB2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurineHuman2750.46
MERTK (MER)AxlTK3bprCB2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurineHuman2760.46
MERTK (MER)AxlTK3bprAA2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurineHuman2780.46
MERTK (MER)AxlTK3bprCA2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurineHuman2840.46
CDK2CDKCMGC1ckpAApurvalanol bHuman40660.45
CDK2CDKCMGC3ddqCAr-roscovitineHuman43641.00
CDK2CDKCMGC5mhqAB(2~{r},3~{s})-3-[[9-propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]pentan-2-olHuman94080.63
CDK2CDKCMGC3dogCA(2r)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-olHuman43820.56
CDK2CDKCMGC3pj8AB(2r)-2-{[7-(benzylamino)-3-(propan-2-yl)-1h-pyrazolo[4,3-d]pyrimidin-5-yl]amino}butan-1-olHuman44540.62
CDK2CDKCMGC3ddpCB(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-olHuman67780.80
CDK2CDKCMGC3dogAA(2r)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-olHuman45410.56
CDK2CDKCMGC3ddpCA(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-olHuman67840.80
CDK2CDKCMGC6rijAA4-[[[5-nitroso-2-[[(2~{r})-1-oxidanylbutan-2-yl]amino]-6-(propan-2-ylamino)pyrimidin-4-yl]amino]methyl]phenolHuman126230.48
CDK2CDKCMGC6rijAB4-[[[5-nitroso-2-[[(2~{r})-1-oxidanylbutan-2-yl]amino]-6-(propan-2-ylamino)pyrimidin-4-yl]amino]methyl]phenolHuman126240.48
CDK2CDKCMGC3ddqAAr-roscovitineHuman44771.00
CDK2CDKCMGC6rijCA4-[[[5-nitroso-2-[[(2~{r})-1-oxidanylbutan-2-yl]amino]-6-(propan-2-ylamino)pyrimidin-4-yl]amino]methyl]phenolHuman126250.48
CDK2CDKCMGC6inlA2,2'-{[6-{[(4-methoxyphenyl)methyl]amino}-9-(propan-2-yl)-9h-purin-2-yl]azanediyl}di(ethan-1-ol)Human117940.49
ABL1AblTK6bl8ABpurvalanol bHuman96980.45
CDK2CDKCMGC2a0cXA2-{[(2-{[(1r)-1-(hydroxymethyl)propyl]amino}-9-isopropyl-9h-purin-6-yl)amino]methyl}phenolHuman41570.83
CDK12 (CRK7)CDKCMGC8burBB~{n}-[2-(2-methoxyphenyl)ethyl]-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]ethanamideHuman149200.48
CDK12 (CRK7)CDKCMGC8burBA~{n}-[2-(2-methoxyphenyl)ethyl]-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]ethanamideHuman149150.48
ABL1AblTK6bl8BBpurvalanol bHuman97000.45
CDK2CDKCMGC1w0xCAolomoucineHuman45370.52
CDK2CDKCMGC3ddqCBr-roscovitineHuman42891.00
RPS6KA1 (RSK3)RSKAGC2z7sA2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9h-purin-2-yl}amino)-3-methylbutan-1-olHuman27760.49
CDK5CDKCMGC1unlAr-roscovitineHuman27851.00
CDK12 (CRK7)CDKCMGC8busB1,3-dimethyl-5-[[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]methyl]pyrazole-4-sulfonamideHuman149080.48
CDK12 (CRK7)CDKCMGC8bu4B(2~{r})-2-[[6-[[5,6-bis(chloranyl)-1~{h}-benzimidazol-2-yl]methylamino]-9-(1-methylpyrazol-4-yl)purin-2-yl]amino]butan-1-olHuman149100.42
CDK12 (CRK7)CDKCMGC8bulB(2~{r})-2-[[6-(3-phenylpropylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-olHuman149110.79
CDK12 (CRK7)CDKCMGC8bu9Br-roscovitineHuman149141.00
CDK12 (CRK7)CDKCMGC8bupB(2~{r})-2-[[6-[3-(3-methylphenyl)propylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-olHuman149230.68
CDK12 (CRK7)CDKCMGC8buiB(2~{r})-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)amino]purin-2-yl]amino]butan-1-olHuman149250.66
CDK12 (CRK7)CDKCMGC8bukB(2~{r})-2-[[6-(naphthalen-2-ylmethylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-olHuman149270.82
CDK12 (CRK7)CDKCMGC8bu1B(2~{r})-2-[[6-[[5,6-bis(chloranyl)-1~{h}-benzimidazol-2-yl]methylamino]-9-(1-methylpyrazol-4-yl)purin-2-yl]amino]butan-1-olHuman149300.42
CDK12 (CRK7)CDKCMGC8bujB(2~{r})-2-[[6-(octylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-olHuman149330.71
CDK12 (CRK7)CDKCMGC8buoB(2~{r})-2-[[6-[(3-fluoranyl-4-pyridin-2-yl-phenyl)methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-olHuman149340.72
CDK12 (CRK7)CDKCMGC8butB2-[[6-[[4-(2-hydroxyethyloxy)phenyl]methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-olHuman149360.77
CDK2CDKCMGC3pj8AA(2r)-2-{[7-(benzylamino)-3-(propan-2-yl)-1h-pyrazolo[4,3-d]pyrimidin-5-yl]amino}butan-1-olHuman43750.62
CDK2CDKCMGC5mhqAA(2~{r},3~{s})-3-[[9-propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]pentan-2-olHuman94090.63
MERTK (MER)AxlTK3bprBA2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurineHuman2810.46
SRPK2SRPKCMGC2x7gApurvalanol bHuman14090.45
MERTK (MER)AxlTK3bprAB2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurineHuman2630.46
CDK2CDKCMGC2a4lAr-roscovitineHuman42381.00
CDK2CDKCMGC3ddpAB(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-olHuman67800.80
CDK9CDKCMGC3lq5A(2s)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-olHuman22530.80
CDK2CDKCMGC1g5sA2-[trans-(4-aminocyclohexyl)amino]-6-(benzyl-amino)-9-cyclopentylpurineHuman38880.41
ABL1AblTK6bl8BApurvalanol bHuman97010.45
ABL1AblTK6bl8AApurvalanol bHuman96990.45
CDK2CDKCMGC2a0cXB2-{[(2-{[(1r)-1-(hydroxymethyl)propyl]amino}-9-isopropyl-9h-purin-6-yl)amino]methyl}phenolHuman38680.83
CDK2CDKCMGC1ckpABpurvalanol bHuman42140.45
CDK2CDKCMGC3dogCB(2r)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-olHuman41210.56
CDK2CDKCMGC1w0xCBolomoucineHuman44780.52
CDK2CDKCMGC3ddpAA(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-olHuman67810.80
CDK2CDKCMGC3dogAB(2r)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-olHuman43650.56
SRCSrcTK1yomB2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9h-purin-2-yl}amino)-3-methylbutan-1-olHuman9870.49
CDK2CDKCMGC8fp0AAr-roscovitineHuman147581.00
CDK2CDKCMGC8fp0ABr-roscovitineHuman147561.00
CDK2CDKCMGC3ddqABr-roscovitineHuman42691.00
CSNK1G1 (CK1g1)CK1CK12cmwAB2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurineHuman55660.46
CSNK1G1 (CK1g1)CK1CK12cmwAA2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurineHuman55670.46
SRCSrcTK1yomA2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9h-purin-2-yl}amino)-3-methylbutan-1-olHuman9730.49
CDK12 (CRK7)CDKCMGC8buqB(2~{r})-2-[[6-[[1-(3-chlorophenyl)pyrazol-3-yl]methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-olHuman149170.65
CDK12 (CRK7)CDKCMGC8buhB6-[[[2-[[(2~{r})-1-oxidanylbutan-2-yl]amino]-9-propan-2-yl-purin-6-yl]amino]methyl]-3-pyridin-2-yl-1~{h}-pyridin-2-oneHuman149220.68
CDK12 (CRK7)CDKCMGC8bumB(2r)-2-[[6-(5-naphthalen-1-ylpentylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-olHuman149240.66
CDK12 (CRK7)CDKCMGC8bunB(2~{r})-2-[[6-[(4-phenylphenyl)methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-olHuman149160.91
CDK12 (CRK7)CDKCMGC8bu3B2-morpholin-4-yl-9-propan-2-yl-~{n}-[(4-pyridin-2-ylphenyl)methyl]purin-6-amineHuman149310.45
CDK12 (CRK7)CDKCMGC6td3E(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-olHuman123690.80
CDK12 (CRK7)CDKCMGC6td3H(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-olHuman123700.80
CDK12 (CRK7)CDKCMGC6td3B(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-olHuman123710.80
CSNK1G3 (CK1g3)CK1CK12izuAB2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9h-purin-2-yl}amino)-3-methylbutan-1-olHuman22250.49
CDK6CDKCMGC2f2cB(2s)-2-({6-[(3-amino-5-chlorophenyl)amino]-9-isopropyl-9h-purin-2-yl}amino)-3-methylbutan-1-olHuman27950.44
CDK2CDKCMGC6rijCB4-[[[5-nitroso-2-[[(2~{r})-1-oxidanylbutan-2-yl]amino]-6-(propan-2-ylamino)pyrimidin-4-yl]amino]methyl]phenolHuman126220.48
SeliciclibMatch:
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