KLIFS - the structural kinase database

Searching for structures with analogs of Semaxanib.

Search results (16 entries covering 8 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
FGFR1	FGFR	TK	1fgi	B	B	3-[(3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene]-2-indolinone	Human	3580	0.49
PIM1	PIM	CAMK	7qfm	A	A	4-[(~{e})-(2-oxidanylidene-1~{h}-indol-3-ylidene)methyl]benzoic acid	Human	14561	0.47
FGFR1	FGFR	TK	1fgi	A	B	3-[(3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene]-2-indolinone	Human	3552	0.49
FGFR1	FGFR	TK	1fgi	A	A	3-[(3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene]-2-indolinone	Human	3555	0.49
PIM1	PIM	CAMK	7qfm	A	B	4-[(~{e})-(2-oxidanylidene-1~{h}-indol-3-ylidene)methyl]benzoic acid	Human	14560	0.47
RET	Ret	TK	2x2m	A		(3z)-3-[(3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-1,3-dihydro-2h-indol-2-one	Human	3366	1.00
RET	Ret	TK	2x2k	A	B	(3z)-5-amino-3-[(3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-1,3-dihydro-2h-indol-2-one	Human	3358	0.71
FGFR1	FGFR	TK	1fgi	B	A	3-[(3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene]-2-indolinone	Human	3586	0.49
DYRK1A	DYRK	CMGC	7a53	A	B	(3~{e})-3-[(5-methylfuran-2-yl)methylidene]-1~{h}-indol-2-one	Human	13741	0.53
DYRK1A	DYRK	CMGC	7a53	A	A	(3~{e})-3-[(5-methylfuran-2-yl)methylidene]-1~{h}-indol-2-one	Human	13755	0.53
CAMKK2 (CaMKK2)	CAMKK	Other	5yvc	A		3-{2,4-dimethyl-5-[(z)-(2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-1h-pyrrol-3-yl}propanoic acid	Human	10754	0.52
NEK2	NEK	Other	2jav	A	A	5-[(z)-(5-chloro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-n-(diethylamino)ethyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide	Human	332	0.43
NEK2	NEK	Other	2jav	A	B	5-[(z)-(5-chloro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-n-(diethylamino)ethyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide	Human	323	0.43
RET	Ret	TK	2x2m	B		(3z)-3-[(3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-1,3-dihydro-2h-indol-2-one	Human	3375	1.00
RET	Ret	TK	2x2k	A	A	(3z)-5-amino-3-[(3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-1,3-dihydro-2h-indol-2-one	Human	3360	0.71
Tbk1 (TBK1)	IKK	Other	4jlc	A		3-{2,4-dimethyl-5-[(z)-(2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-1h-pyrrol-3-yl}propanoic acid	Mouse	5698	0.52