Searching for structures with analogs of Tivozanib.

Search results (23 entries covering 16 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetailsSimilarity (MFP)File
SYKSykTK3tubA1-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-3-[(1r,2s)-2-phenylcyclopropyl]ureaHuman11790.49
SYKSykTK3tucA1-benzyl-n-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-2-oxo-1,2-dihydropyridine-3-carboxamideHuman11950.46
CHEK1 (CHK1)CAMKLCAMK4ft3AA1-(5-chloro-2,4-dimethoxyphenyl)-3-pyrazin-2-ylureaHuman15540.40
CHEK1 (CHK1)CAMKLCAMK4ft3AB1-(5-chloro-2,4-dimethoxyphenyl)-3-pyrazin-2-ylureaHuman16720.40
METMetTK3u6hABn-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxamideHuman29650.44
METMetTK3vw8An-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamothioyl)-2-phenylacetamideHuman29850.48
FGFR1FGFRTK4rwlB6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-n-methylnaphthalene-1-carboxamideHuman35960.45
KDRVEGFRTK3wzdAA4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamideHuman53250.61
KDRVEGFRTK3b8rAn-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamideHuman53270.47
KDRVEGFRTK2rl5An-(4-chlorophenyl)-7-[(6,7-dimethoxyquinolin-4-yl)oxy]-2,3-dihydro-1,4-benzoxazine-4-carboxamideHuman53480.49
KDRVEGFRTK3b8qBn-(4-chlorophenyl)-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamideHuman53190.49
KDRVEGFRTK3u6jAn-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxamideHuman53180.44
KDRVEGFRTK3b8rBn-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamideHuman53410.47
ALKALKTK4fnyAn-(4-chlorophenyl)-5-[(6,7-dimethoxyquinolin-4-yl)oxy]-1,3-benzoxazol-2-amineHuman53670.48
CHEK1 (CHK1)CAMKLCAMK2ywpA1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureaHuman16580.42
KDRVEGFRTK3wzdAB4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamideHuman53500.61
KDRVEGFRTK4aseAtivozanibHuman53490.65
METMetTK3u6hAAn-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxamideHuman29960.44
KDRVEGFRTK3b8qAn-(4-chlorophenyl)-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamideHuman53320.49
EIF2AK3 (PEK)PEKOther4x7hABn-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1h-pyrazole-4-carboxamideHuman72400.44
EIF2AK3 (PEK)PEKOther4x7hAAn-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1h-pyrazole-4-carboxamideHuman72470.44
FGFR1FGFRTK5zv2A4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamideHuman100550.61
FGFR1FGFRTK5zv2B4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamideHuman100540.61