KLIFS - the structural kinase database

Searching for structures with analogs of Cerdulatinib.

Search results (100 entries covering 30 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
MAPK1 (Erk2)	MAPK	CMGC	6g54	A	B	n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide	Human	10937	0.45
SYK	Syk	TK	3fqe	A		2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide	Human	1155	0.40
SYK	Syk	TK	3srv	A	A	2-{[(3r,4r)-3-aminotetrahydro-2h-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide	Human	1154	0.44
SYK	Syk	TK	3srv	B	B	2-{[(3r,4r)-3-aminotetrahydro-2h-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide	Human	1206	0.44
SYK	Syk	TK	3srv	B	A	2-{[(3r,4r)-3-aminotetrahydro-2h-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide	Human	1181	0.44
MAP4K1 (HPK1)	STE20	STE	7m0k	B	B	4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide	Human	13470	0.40
MAP4K1 (HPK1)	STE20	STE	7m0k	D	B	4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide	Human	13471	0.40
MAPK3 (Erk1)	MAPK	CMGC	6ges	A	B	n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide	Human	10926	0.45
MAP4K1 (HPK1)	STE20	STE	7m0k	C	B	4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide	Human	13474	0.40
JAK2	JakA	TK	4bbe	B		n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide	Human	3727	0.41
MAP4K1 (HPK1)	STE20	STE	7m0k	D	A	4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide	Human	13479	0.40
EGFR	EGFR	TK	5x2f	C	A	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9527	0.41
EGFR	EGFR	TK	5x2f	A	A	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9540	0.41
MERTK (MER)	Axl	TK	4mha	B	A	2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-n-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide	Human	268	0.42
MERTK (MER)	Axl	TK	7m5z	A	A	2-(butylamino)-n-[1-(3-fluoropropyl)piperidin-4-yl]-4-{[(1r,4r)-4-hydroxycyclohexyl]amino}pyrimidine-5-carboxamide	Human	13919	0.43
MERTK (MER)	Axl	TK	7m5z	A	B	2-(butylamino)-n-[1-(3-fluoropropyl)piperidin-4-yl]-4-{[(1r,4r)-4-hydroxycyclohexyl]amino}pyrimidine-5-carboxamide	Human	13920	0.43
MERTK (MER)	Axl	TK	4mha	A	B	2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-n-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide	Human	277	0.42
MERTK (MER)	Axl	TK	4mha	A	A	2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-n-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide	Human	264	0.42
SRC	Src	TK	6e6e	E	A	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11479	0.41
EGFR	EGFR	TK	5x2a	A	A	n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine	Human	9545	0.41
SRC	Src	TK	6e6e	G	A	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11493	0.41
MERTK (MER)	Axl	TK	4mha	B	B	2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-n-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide	Human	270	0.42
EGFR	EGFR	TK	7lg8	A		6-ethyl-3-[[4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-[(3r)-1-prop-2-enoylpyrrolidin-3-yl]oxy-pyrazine-2-carboxamide	Human	14120	0.40
EGFR	EGFR	TK	5x2a	B	B	n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine	Human	9548	0.41
EGFR	EGFR	TK	5x2a	A	B	n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine	Human	9530	0.41
EGFR	EGFR	TK	5x2f	D	A	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9544	0.41
EGFR	EGFR	TK	5x2a	C	C	n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine	Human	9547	0.41
EGFR	EGFR	TK	5x2c	B	C	9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9570	0.42
EGFR	EGFR	TK	5x2c	B	A	9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9569	0.42
EGFR	EGFR	TK	5x2f	B	B	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9541	0.41
EGFR	EGFR	TK	5x2c	B	B	9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9571	0.42
EGFR	EGFR	TK	5x2c	A	C	9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9566	0.42
EGFR	EGFR	TK	5x2c	A	B	9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9567	0.42
EGFR	EGFR	TK	5x2f	D	B	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9528	0.41
SRC	Src	TK	6e6e	A	B	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11482	0.41
JAK2	JakA	TK	4ji9	A		n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide	Human	3692	0.40
TTK	TTK	Other	5ljj	A		n~6~-cyclohexyl-n~2~-(4-morpholin-4-ylphenyl)-9h-purine-2,6-diamine	Human	7092	0.46
EGFR	EGFR	TK	5x2c	A	A	9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9572	0.42
JAK2	JakA	TK	5hez	A		n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide	Human	7254	0.40
SYK	Syk	TK	3srv	A	B	2-{[(3r,4r)-3-aminotetrahydro-2h-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide	Human	1162	0.44
JAK2	JakA	TK	4bbe	C		n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide	Human	3649	0.41
JAK2	JakA	TK	5hez	D		n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide	Human	7252	0.40
TNK2 (ACK)	Ack	TK	7kp6	A	B	5-chloro-n~2~-[4-(4-methylpiperazin-1-yl)phenyl]-n~4~-{[(2r)-oxolan-2-yl]methyl}pyrimidine-2,4-diamine	Human	14103	0.49
JAK2	JakA	TK	4bbe	A		n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide	Human	3670	0.41
EGFR	EGFR	TK	5x2a	A	C	n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine	Human	9539	0.41
EGFR	EGFR	TK	5x28	A		9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9538	0.41
EGFR	EGFR	TK	5x2a	B	C	n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine	Human	9543	0.41
EGFR	EGFR	TK	5x2f	B	A	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9546	0.41
EGFR	EGFR	TK	5x26	A		n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine	Human	9536	0.41
JAK2	JakA	TK	4ji9	B		n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide	Human	3724	0.40
EGFR	EGFR	TK	5y9t	A		6-ethyl-3-[[4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-[(3r)-1-prop-2-enoylpyrrolidin-3-yl]oxy-pyrazine-2-carboxamide	Human	10053	0.40
JAK2	JakA	TK	5hez	B		n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide	Human	7255	0.40
JAK2	JakA	TK	5hez	C		n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide	Human	7253	0.40
EGFR	EGFR	TK	5x2a	C	A	n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine	Human	9537	0.41
MAP4K1 (HPK1)	STE20	STE	7m0k	C	A	4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide	Human	13473	0.40
MAP4K1 (HPK1)	STE20	STE	7m0k	A	A	4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide	Human	13480	0.40
MAP4K1 (HPK1)	STE20	STE	7m0k	A	B	4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide	Human	13481	0.40
MAPK3 (Erk1)	MAPK	CMGC	6ges	A	A	n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide	Human	10923	0.45
TNK2 (ACK)	Ack	TK	7kp6	A	A	5-chloro-n~2~-[4-(4-methylpiperazin-1-yl)phenyl]-n~4~-{[(2r)-oxolan-2-yl]methyl}pyrimidine-2,4-diamine	Human	14104	0.49
MAPK3 (Erk1)	MAPK	CMGC	6ges	B	B	n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide	Human	10924	0.45
MAPK3 (Erk1)	MAPK	CMGC	6ges	B	A	n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide	Human	10925	0.45
MAP3K7 (TAK1)	MLK	TKL	5j8i	A		n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide	Human	7428	0.41
SRC	Src	TK	6ate	A		n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide	Human	10920	0.45
EGFR	EGFR	TK	5x2f	A	B	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9535	0.41
EGFR	EGFR	TK	5x2a	C	B	n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine	Human	9531	0.41
EGFR	EGFR	TK	5x2a	B	A	n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine	Human	9526	0.41
AURKA (AurA)	Aur	Other	3qbn	A		5-chloro-n~4~-cyclopropyl-n~2~-[4-(2-methoxyethoxy)phenyl]pyrimidine-2,4-diamine	Human	2032	0.46
MAPK1 (Erk2)	MAPK	CMGC	6g54	A	A	n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide	Human	10938	0.45
JAK2	JakA	TK	8bx6	A	A	cerdulatinib	Human	15033	1.00
EGFR	EGFR	TK	5x2f	C	B	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9542	0.41
SRC	Src	TK	6e6e	F	C	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11486	0.41
JAK2	JakA	TK	4bbe	D		n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide	Human	3726	0.41
JAK2	JakA	TK	8bx6	A	B	cerdulatinib	Human	15042	1.00
SRC	Src	TK	6e6e	A	A	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11485	0.41
SRC	Src	TK	6e6e	H	C	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11481	0.41
SRC	Src	TK	6e6e	C	B	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11492	0.41
SRC	Src	TK	6e6e	A	C	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11491	0.41
SRC	Src	TK	6e6e	D	B	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11494	0.41
SRC	Src	TK	6e6e	E	B	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11490	0.41
SRC	Src	TK	6e6e	F	A	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11487	0.41
SRC	Src	TK	6e6e	F	B	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11472	0.41
SRC	Src	TK	6e6e	D	A	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11489	0.41
SRC	Src	TK	6e6e	B	C	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11484	0.41
SRC	Src	TK	6e6e	D	C	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11473	0.41
SRC	Src	TK	6e6e	B	A	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11480	0.41
SRC	Src	TK	6e6e	G	B	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11474	0.41
SRC	Src	TK	6e6e	C	A	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11471	0.41
SRC	Src	TK	6e6e	E	C	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11478	0.41
SRC	Src	TK	6e6e	H	A	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11475	0.41
SRC	Src	TK	6e6e	B	B	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11476	0.41
MAP4K1 (HPK1)	STE20	STE	7m0k	B	A	4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide	Human	13476	0.40
MAP3K7 (TAK1)	MLK	TKL	5j7s	A		n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide	Human	7429	0.45
MAPK1 (Erk2)	MAPK	CMGC	4zzm	A		7-ethylsulfonyl-n-(oxan-4-yl)-6,8-dihydro-5h-pyrido[3,4-d]pyrimidin-2-amine	Human	2616	0.42
MAP3K7 (TAK1)	MLK	TKL	5jh6	A		2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl prop-2-enoate	Human	7427	0.41
MAP3K7 (TAK1)	MLK	TKL	5e7r	A		2-chloro-n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}acetamide	Human	7412	0.42
INSR	InsR	TK	2z8c	A		[4-({5-(aminocarbonyl)-4-[(3-methylphenyl)amino]pyrimidin-2-yl}amino)phenyl]acetic acid	Human	587	0.40
EGFR	EGFR	TK	5x27	A		9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9534	0.42
SRC	Src	TK	6e6e	H	B	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11483	0.41
SRC	Src	TK	6e6e	G	C	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11477	0.41
SRC	Src	TK	6e6e	C	C	n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide	Human	11488	0.41