Searching for structures with analogs of Dacomitinib.

Search results (25 entries covering 17 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetailsSimilarity (MFP)File
EPHB4 (EphB4)EphTK2vwuAn-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amineHuman3700.43
EGFREGFRTK2ityAgefitinibHuman7900.54
EGFREGFRTK2itzAgefitinibHuman7890.54
EGFREGFRTK3ug2ABgefitinibHuman8190.54
EGFREGFRTK4i22AgefitinibHuman8230.54
EGFREGFRTK4i24A(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamideHuman8311.00
EGFREGFRTK4g5pAn-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamideHuman8090.52
EGFREGFRTK4wkqABgefitinibHuman8370.54
EGFREGFRTK4i23A(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamideHuman8701.00
EGFREGFRTK4g5jABn-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamideHuman8520.52
EGFREGFRTK4wkqAAgefitinibHuman8890.54
EGFREGFRTK4i24B(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamideHuman9101.00
EGFREGFRTK3ug2AAgefitinibHuman8980.54
AURKA (AurA)AurOther2c6eBn-{5-[(7-{[(2s)-2-hydroxy-3-piperidin-1-ylpropyl]oxy}-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamideHuman20460.46
EGFREGFRTK4g5jAAn-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamideHuman7940.52
AURKA (AurA)AurOther2c6eAn-{5-[(7-{[(2s)-2-hydroxy-3-piperidin-1-ylpropyl]oxy}-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamideHuman19890.46
RETRetTK2ivuA4-bromo-2-fluoro-n-[(4e)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4(1h)-ylidene]anilineHuman33640.40
EGFREGFRTK2itoAgefitinibHuman7830.54
PKMYT1 (MYT1)WEEOther5vcwA(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamideHuman83350.49
PKMYT1 (MYT1)WEEOther5vcwB(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamideHuman83460.49
GAKNAKOther5y7zAgefitinibHuman103320.54
GAKNAKOther5y7zBgefitinibHuman103310.54
GAKNAKOther5y80ABgefitinibHuman103300.54
GAKNAKOther5y80AAgefitinibHuman103290.54
EGFREGFRTK5y25A(2r)-n-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]-1-(2-fluoranylethanoyl)pyrrolidine-2-carboxamideHuman103730.53