| MET | Met | TK | 4knb | A | B | 7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine | Human | 3037 | 0.70 | |
| ROS1 (ROS) | Sev | TK | 3zbf | A | | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 197 | 1.00 | |
| ALK | ALK | TK | 2xp2 | A | | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 5394 | 1.00 | |
| ALK | ALK | TK | 5aab | A | B | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 6681 | 1.00 | |
| ALK | ALK | TK | 5aac | A | A | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 6690 | 1.00 | |
| ALK | ALK | TK | 2yfx | A | | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 5402 | 1.00 | |
| ALK | ALK | TK | 5aaa | A | A | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 6691 | 1.00 | |
| ALK | ALK | TK | 5aac | A | B | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 6686 | 1.00 | |
| ALK | ALK | TK | 5aaa | A | B | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 6683 | 1.00 | |
| ALK | ALK | TK | 5aab | A | A | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 6689 | 1.00 | |
| ALK | ALK | TK | 4anq | A | | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 5368 | 1.00 | |
| ALK | ALK | TK | 4ans | A | | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 5374 | 1.00 | |
| MET | Met | TK | 4knb | B | A | 7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine | Human | 3007 | 0.70 | |
| MET | Met | TK | 7b43 | A | | 3-[(4-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridine | Human | 13189 | 0.43 | |
| MET | Met | TK | 7b42 | A | | 3-[(3-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridine | Human | 13190 | 0.42 | |
| MET | Met | TK | 3a4p | A | | (2e)-3-{6-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl}-n-methylprop-2-enamide | Human | 3005 | 0.40 | |
| PAK1 | STE20 | STE | 5kbr | A | | (4-chlorophenyl)-[5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridin-3-yl]methanone | Human | 7080 | 0.46 | |
| PAK1 | STE20 | STE | 5kbr | B | | (4-chlorophenyl)-[5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridin-3-yl]methanone | Human | 7079 | 0.46 | |
| PAK1 | STE20 | STE | 4p90 | A | | [2-chloro-5-(hydroxymethyl)phenyl]{5-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridin-3-yl}methanone | Human | 164 | 0.43 | |
| PAK1 | STE20 | STE | 4p90 | B | | [2-chloro-5-(hydroxymethyl)phenyl]{5-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridin-3-yl}methanone | Human | 151 | 0.43 | |
| MET | Met | TK | 4knb | C | A | 7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine | Human | 2955 | 0.70 | |
| MET | Met | TK | 4knb | B | B | 7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine | Human | 2970 | 0.70 | |
| MET | Met | TK | 4knb | C | B | 7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine | Human | 3001 | 0.70 | |
| MET | Met | TK | 2wgj | A | | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 3009 | 1.00 | |
| MET | Met | TK | 7b41 | A | A | 3-[(2-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridine | Human | 13184 | 0.48 | |
| MET | Met | TK | 4knb | D | B | 7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine | Human | 2968 | 0.70 | |
| MET | Met | TK | 4knb | A | A | 7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine | Human | 2960 | 0.70 | |
| MET | Met | TK | 7b43 | B | | 3-[(4-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridine | Human | 13187 | 0.43 | |
| MET | Met | TK | 7b40 | A | | 3-(phenylmethyl)-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridine | Human | 13192 | 0.40 | |
| MET | Met | TK | 4knb | D | A | 7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine | Human | 3010 | 0.70 | |
| MET | Met | TK | 7b41 | A | B | 3-[(2-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridine | Human | 13193 | 0.48 | |
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