KLIFS - the structural kinase database

Searching for structures with analogs of Dabrafenib.

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
BRAF	RAF	TKL	4xv2	A		dabrafenib	Human	6213	1.00
BRAF	RAF	TKL	7p3v	A		~{n}-[3-[5-(2-azanylpyrimidin-4-yl)-2-[(3~{s})-morpholin-3-yl]-1,3-thiazol-4-yl]-2-fluoranyl-phenyl]-2,5-bis(fluoranyl)benzenesulfonamide	Human	13961	0.53
BRAF	RAF	TKL	5hie	D	A	dabrafenib	Human	6510	1.00
BRAF	RAF	TKL	4xv3	A		n'-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-n-ethyl-n-methylsulfuric diamide	Human	6217	0.70
BRAF	RAF	TKL	5hie	A	A	dabrafenib	Human	6516	1.00
BRAF	RAF	TKL	5hie	B	B	dabrafenib	Human	6505	1.00
BRAF	RAF	TKL	5hie	C	B	dabrafenib	Human	6507	1.00
BRAF	RAF	TKL	5csw	B		dabrafenib	Human	6431	1.00
BRAF	RAF	TKL	5hie	C	A	dabrafenib	Human	6513	1.00
BRAF	RAF	TKL	5hie	D	B	dabrafenib	Human	6514	1.00
BRAF	RAF	TKL	6v2u	B		dabrafenib	Human	13031	1.00
BRAF	RAF	TKL	5hie	B	A	dabrafenib	Human	6509	1.00
BRAF	RAF	TKL	5hie	A	B	dabrafenib	Human	6508	1.00
BRAF	RAF	TKL	6v2u	A		dabrafenib	Human	13034	1.00
BRAF	RAF	TKL	4xv2	B		dabrafenib	Human	6219	1.00
BRAF	RAF	TKL	5csw	A		dabrafenib	Human	6433	1.00