KLIFS - the structural kinase database

Searching for structures with analogs of Decernotinib.

Search results (14 entries covering 4 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
JAK3	JakA	TK	7apg	B	A	~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide	Human	13131	0.40
JAK3	JakA	TK	7apg	C	A	~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide	Human	13140	0.40
JAK2	JakA	TK	4yth	A	B	n~2~-[2-(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-2-methyl-n-(2,2,2-trifluoroethyl)-d-alaninamide	Human	3702	0.47
JAK2	JakA	TK	4yth	A	A	n~2~-[2-(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-2-methyl-n-(2,2,2-trifluoroethyl)-d-alaninamide	Human	3710	0.47
JAK3	JakA	TK	7apg	D	A	~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide	Human	13138	0.40
JAK3	JakA	TK	7apg	C	B	~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide	Human	13139	0.40
JAK3	JakA	TK	7apg	D	B	~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide	Human	13133	0.40
JAK3	JakA	TK	7apg	A	A	~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide	Human	13134	0.40
JAK3	JakA	TK	7apg	A	B	~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide	Human	13135	0.40
JAK2	JakA	TK	4yti	A	B	(2r)-2-methyl-2-[[2-(1h-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-n-[2,2,2-tris(fluoranyl)ethyl]butanamide	Human	3657	1.00
JAK3	JakA	TK	7apg	B	B	~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide	Human	13136	0.40
DYRK1A	DYRK	CMGC	6s1h	A	A	~{n},~{n}-dimethyl-4-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine	Human	11419	0.42
DYRK1A	DYRK	CMGC	6s1h	A	B	~{n},~{n}-dimethyl-4-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine	Human	11420	0.42
JAK2	JakA	TK	4yti	A	A	(2r)-2-methyl-2-[[2-(1h-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-n-[2,2,2-tris(fluoranyl)ethyl]butanamide	Human	3641	1.00