Searching for structures with analogs of Entrectinib.

Search results (21 entries covering 8 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetailsSimilarity (MFP)File
AURKA (AurA)AurOther2bmcD(3e)-n-(2,6-diethylphenyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]imino}pyrrolo[3,4-c]pyrazole-5(3h)-carboxamideHuman19840.42
AURKA (AurA)AurOther2j4zB4-(4-methylpiperazin-1-yl)-n-[5-(2-thienylacetyl)-1,5-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamideHuman19900.40
AURKA (AurA)AurOther2bmcB(3e)-n-(2,6-diethylphenyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]imino}pyrrolo[3,4-c]pyrazole-5(3h)-carboxamideHuman20080.42
AURKA (AurA)AurOther2bmcC(3e)-n-(2,6-diethylphenyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]imino}pyrrolo[3,4-c]pyrazole-5(3h)-carboxamideHuman20600.42
AURKA (AurA)AurOther2j4zA4-(4-methylpiperazin-1-yl)-n-[5-(2-thienylacetyl)-1,5-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamideHuman20530.40
CDK2CDKCMGC2r64An-[5-(1,1-dioxidoisothiazolidin-2-yl)-1h-indazol-3-yl]-2-(4-piperidin-1-ylphenyl)acetamideHuman44250.44
PLK1PLKOther2owbAB4-(4-methylpiperazin-1-yl)-n-[5-(2-thienylacetyl)-1,5-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamideHuman49580.40
PLK1PLKOther2owbAA4-(4-methylpiperazin-1-yl)-n-[5-(2-thienylacetyl)-1,5-dihydropyrrolo[3,4-c]pyrazol-3-yl]benzamideHuman49740.40
AURKA (AurA)AurOther2bmcF(3e)-n-(2,6-diethylphenyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]imino}pyrrolo[3,4-c]pyrazole-5(3h)-carboxamideHuman19930.42
FGFR1FGFRTK4uwbBAn-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-3-carboxamideHuman60180.42
FGFR1FGFRTK4uwbAAn-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-3-carboxamideHuman60200.42
FGFR1FGFRTK4uwbABn-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-3-carboxamideHuman60230.42
FGFR1FGFRTK4uwbBBn-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-3-carboxamideHuman60220.42
ALKALKTK5ftqABn-[5-(3,5-difluorobenzyl)-1h-indazol-3-yl]-2-[(4-hydroxycyclohexyl)amino]-4-(4-methylpiperazin-1-yl) benzamideHuman65180.89
ALKALKTK5ftqAAn-[5-(3,5-difluorobenzyl)-1h-indazol-3-yl]-2-[(4-hydroxycyclohexyl)amino]-4-(4-methylpiperazin-1-yl) benzamideHuman65190.89
ALKALKTK5ftoAAentrectinibHuman65200.63
ALKALKTK5ftoABentrectinibHuman65210.63
AURKA (AurA)AurOther2bmcA(3e)-n-(2,6-diethylphenyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]imino}pyrrolo[3,4-c]pyrazole-5(3h)-carboxamideHuman20150.42
AURKA (AurA)AurOther2bmcE(3e)-n-(2,6-diethylphenyl)-3-{[4-(4-methylpiperazin-1-yl)benzoyl]imino}pyrrolo[3,4-c]pyrazole-5(3h)-carboxamideHuman20690.42
NTRK1 (TRKA)TrkTK5kvtAAentrectinibHuman94500.63
NTRK1 (TRKA)TrkTK5kvtABentrectinibHuman94510.63